• 4816 Citations
  • 42 h-Index
1990 …2020

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2020

Dietary aHR ligands regulate ahrr expression in intestinal immune cells and intestinal microbiota composition

Schanz, O., Chijiiwa, R., Cengiz, S. C., Majlesain, Y., Weighardt, H., Takeyama, H. & Förster, I., 2020 May 1, In : International journal of molecular sciences. 21, 9, 3189.

Research output: Contribution to journalArticle

Open Access

Effective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis

Yamazaki, M., Hosokawa, M., Arikawa, K., Takahashi, K., Sakanashi, C., Yoda, T., Matsunaga, H. & Takeyama, H., 2020 Dec 1, In : Scientific reports. 10, 1, 7083.

Research output: Contribution to journalArticle

Open Access

Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity by RNA-seq analysis

Yumoto, M., Hemmi, N., Sato, N., Kawashima, Y., Arikawa, K., Ide, K., Hosokawa, M., Seo, M. & Takeyama, H., 2020 Dec 1, In : Scientific reports. 10, 1, 7158.

Research output: Contribution to journalArticle

Open Access

Interleukin-17A/F1 Deficiency Reduces Antimicrobial Gene Expression and Contributes to Microbiome Alterations in Intestines of Japanese medaka (Oryzias latipes)

Okamura, Y., Morimoto, N., Ikeda, D., Mizusawa, N., Watabe, S., Miyanishi, H., Saeki, Y., Takeyama, H., Aoki, T., Kinoshita, M., Kono, T., Sakai, M. & Hikima, J. I., 2020 Mar 17, In : Frontiers in Immunology. 11, 425.

Research output: Contribution to journalArticle

Open Access

Molecular profiling of lipid droplets inside HuH7 cells with Raman micro-spectroscopy

Samuel, A. Z., Miyaoka, R., Ando, M., Gaebler, A., Thiele, C. & Takeyama, H., 2020 Dec 1, In : Communications Biology. 3, 1, 372.

Research output: Contribution to journalArticle

Open Access

Rapid inspection method for investigating the heat processing conditions employed for chicken meat using Raman spectroscopy

Miyaoka, R., Ando, M., Harada, R., Osaka, H., Samuel, A. Z., Hosokawa, M. & Takeyama, H., 2020 Jun, In : Journal of Bioscience and Bioengineering. 129, 6, p. 700-705 6 p.

Research output: Contribution to journalArticle

Single-cell genomics of uncultured bacteria reveals dietary fiber responders in the mouse gut microbiota

Chijiiwa, R., Hosokawa, M., Kogawa, M., Nishikawa, Y., Ide, K., Sakanashi, C., Takahashi, K. & Takeyama, H., 2020 Jan 23, In : Microbiome. 8, 1, 5.

Research output: Contribution to journalArticle

Open Access

Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization

Ogawa, M., Takada, N., Shizukuishi, S., Tomokiyo, M., Chang, B., Yoshida, M., Kakuta, S., Tanida, I., Ryo, A., Guan, J. L., Takeyama, H. & Ohnishi, M., 2020 Dec 1, In : Communications Biology. 3, 1, 25.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The draft genome dataset of the asian cricket teleogryllus occipitalis for molecular research toward entomophagy

Kataoka, K., Minei, R., Ide, K., Ogura, A., Takeyama, H., Takeda, M., Suzuki, T., Yura, K. & Asahi, T., 2020, In : Frontiers in Genetics. 11, 470.

Research output: Contribution to journalArticle

Open Access

Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast

Tsuyuzaki, H., Hosokawa, M., Arikawa, K., Yoda, T., Okada, N., Takeyama, H. & Sato, M., 2020 Dec 1, In : Nature communications. 11, 1, 1265.

Research output: Contribution to journalArticle

Open Access
2019

A CCR5 + memory subset within HIV-1-infected primary resting CD4 + T cells is permissive for replication-competent, latently infected viruses in vitro

Terahara, K., Iwabuchi, R., Hosokawa, M., Nishikawa, Y., Takeyama, H., Takahashi, Y. & Tsunetsugu-Yokota, Y., 2019 Apr 29, In : BMC Research Notes. 12, 1, 242.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

An estrogen antagonist, cyclofenil, has anti-dengue-virus activity

Tohma, D., Tajima, S., Kato, F., Sato, H., Kakisaka, M., Hishiki, T., Kataoka, M., Takeyama, H., Lim, C. K., Aida, Y. & Saijo, M., 2019 Jan 22, In : Archives of Virology. 164, 1, p. 225-234 10 p.

Research output: Contribution to journalArticle

Enrichment of bacteria and alginate lyase genes potentially involved in brown alga degradation in the gut of marine gastropods

Ito, M., Watanabe, K., Maruyama, T., Mori, T., Niwa, K., Chow, S. & Takeyama, H., 2019 Dec 1, In : Scientific reports. 9, 1, 2129.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Adachi, Y., Tonouchi, K., Nithichanon, A., Kuraoka, M., Watanabe, A., Shinnakasu, R., Asanuma, H., Ainai, A., Ohmi, Y., Yamamoto, T., Ishii, K. J., Hasegawa, H., Takeyama, H., Lertmemongkolchai, G., Kurosaki, T., Ato, M., Kelsoe, G. & Takahashi, Y., 2019 Dec 1, In : Nature communications. 10, 1, 3883.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

High-throughput identification of peptide agonists against GPCRs by co-culture of mammalian reporter cells and peptide-secreting yeast cells using droplet microfluidics

Yaginuma, K., Aoki, W., Miura, N., Ohtani, Y., Aburaya, S., Kogawa, M., Nishikawa, Y., Hosokawa, M., Takeyama, H. & Ueda, M., 2019 Dec 1, In : Scientific reports. 9, 1, 10920.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Saito, S., Sano, K., Suzuki, T., Ainai, A., Taga, Y., Ueno, T., Tabata, K., Saito, K., Wada, Y., Ohara, Y., Takeyama, H., Odagiri, T., Kageyama, T., Ogawa-Goto, K., Multihartina, P., Setiawaty, V., Pangesti, K. N. A. & Hasegawa, H., 2019 Jan 1, In : PLoS Pathogens. 15, 1, p. e1007427

Research output: Contribution to journalArticle

5 Citations (Scopus)

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Matsumura, T., Ikebe, T., Arikawa, K., Hosokawa, M., Aiko, M., Iguchi, A., Togashi, I., Kai, S., Ohara, S., Ohara, N., Ohnishi, M., Watanabe, H., Kobayashi, K., Takeyama, H., Yamasaki, S., Takahashi, Y. & Ato, M., 2019 Apr 9, In : Cell Reports. 27, 2, p. 561-571.e6

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Acyclovir sensitivity and neurovirulence of herpes simplex virus type 1 with amino acid substitutions in the viral thymidine kinase gene, which were detected in the patients with intractable herpes simplex encephalitis previously reported

Inagaki, T., Satoh, M., Fujii, H., Yamada, S., Shibamura, M., Yoshikawa, T., Harada, S., Takeyama, H. & Saijo, M., 2018 Jan 1, In : Japanese Journal of Infectious Diseases. 71, 5, p. 343-349 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A metabarcoding survey for seasonal picophytoplankton composition in two coral reefs around Sesoko Island, Okinawa, Japan

Nuryadi, H., Nguyen, T. T. M., Ito, M., Okada, N., Wakaoji, S., Maruyama, T., Nakano, Y., Fujimura, H., Takeyama, H. & Suda, S., 2018 Dec 1, In : Journal of Applied Phycology. 30, 6, p. 3179-3186 8 p.

Research output: Contribution to journalArticle

A novel system for constructing a recombinant highly-attenuated Vaccinia virus strain (LC16m8) expressing foreign genes and its application for the generation of LC16m8-based vaccines against herpes simplex virus 2

Omura, N., Yoshikawa, T., Fujii, H., Shibamura, M., Inagaki, T., Kato, H., Egawa, K., Harada, S., Yamada, S., Takeyama, H. & Saijo, M., 2018 Jan 1, In : Japanese Journal of Infectious Diseases. 71, 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response

Kashima, Y., Suzuki, A., Liu, Y., Hosokawa, M., Matsunaga, H., Shirai, M., Arikawa, K., Sugano, S., Kohno, T., Takeyama, H., Tsuchihara, K. & Suzuki, Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 3482.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effects of short-term endurance exercise on gut microbiota in elderly men

Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., Hoshino, Y., Hosokawa, M., Takeyama, H. & Higuchi, M., 2018 Dec 1, In : Physiological Reports. 6, 23, e13935.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

The Alzheimer's Disease Neuroimaging Initiative, 2018 May, In : Alzheimer's and Dementia. 14, 5, p. 623-633 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Introduction of human Flt3-L and GM-CSF into humanized mice enhances the reconstitution and maturation of myeloid dendritic cells and the development of Foxp3+CD4+ T cells

Iwabuchi, R., Ikeno, S., Kobayashi-Ishihara, M., Takeyama, H., Ato, M., Tsunetsugu-Yokota, Y. & Terahara, K., 2018 May 28, In : Frontiers in Immunology. 9, MAY, 1042.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination

Ogawa, M., Matsuda, R., Takada, N., Tomokiyo, M., Yamamoto, S., Shizukusihi, S., Yamaji, T., Yoshikawa, Y., Yoshida, M., Tanida, I., Koike, M., Murai, M., Morita, H., Takeyama, H., Ryo, A., Guan, J. L., Yamamoto, M., Inoue, J. I., Yanagawa, T., Fukuda, M. & 2 others, Kawabe, H. & Ohnishi, M., 2018 Aug, In : Cellular Microbiology. 20, 8, e12846.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Obtaining high-quality draft genomes from uncultured microbes by cleaning and co-assembly of single-cell amplified genomes

Kogawa, M., Hosokawa, M., Nishikawa, Y., Mori, K. & Takeyama, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2059.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Protection of Coral Larvae from Thermally Induced Oxidative Stress by Redox Nanoparticles

Motone, K., Takagi, T., Aburaya, S., Aoki, W., Miura, N., Minakuchi, H., Takeyama, H., Nagasaki, Y., Shinzato, C. & Ueda, M., 2018 Aug 1, In : Marine Biotechnology. 20, 4, p. 542-548 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts

Mori, T., Cahn, J. K. B., Wilson, M. C., Meoded, R. A., Wiebach, V., Martinez, A. F. C., Helfrich, E. J. N., Albersmeier, A., Wibberg, D., Dätwyler, S., Keren, R., Lavy, A., Rückert, C., Ilan, M., Kalinowski, J., Matsunaga, S., Takeyama, H. & Piel, J., 2018 Feb 20, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. 1718-1723 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The impact of Uva tea extract capsule consumption on psychological stress: A randomized, double-blind, placebo-controlled, crossover trial

Takamizawa, N., Yamashita, S., Suzuki, N., Yamamoto, K., Takeyama, H., Yazawa, K. & Takara, T., 2018 Jan 1, In : Japanese Pharmacology and Therapeutics. 46, 12, p. 2001-2010 10 p.

Research output: Contribution to journalArticle

2017

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Wada, Y., Nithichanon, A., Nobusawa, E., Moise, L., Martin, W. D., Yamamoto, N., Terahara, K., Hagiwara, H., Odagiri, T., Tashiro, M., Lertmemongkolchai, G., Takeyama, H., Groot, A. S. D., Ato, M. & Takahashi, Y., 2017 Dec 1, In : Scientific Reports. 7, 1, 1283.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antimicrobial peptides extend lifespan in Drosophila

Loch, G., Zinke, I., Mori, T., Carrera, P., Schroer, J., Takeyama, H. & Hoch, M., 2017 May 1, In : PLoS One. 12, 5, e0176689.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence

Omura, N., Fujii, H., Yoshikawa, T., Yamada, S., Harada, S., Inagaki, T., Shibamura, M., Takeyama, H. & Saijo, M., 2017 Mar 21, In : Virology Journal. 14, 1, 59.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Complete genome sequence of Photobacterium damselae subsp. piscicida strain OT-51443 isolated from yellowtail (Seriola quinqueradiata) in Japan

Aoki, T., Teru, Y., Morimoto, N., Kono, T., Sakai, M., Takano, T., Hawke, J. P., Fukuda, Y., Takeyama, H. & Hikima, J. I., 2017 Jan 1, In : Genome Announcements. 5, 21, e00404-17.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA

Yoda, T., Tanabe, M., Tsuji, T., Yoda, T., Ishino, S., Shirai, T., Ishino, Y., Takeyama, H. & Nishida, H., 2017 Mar 16, In : Scientific Reports. 7, 44582.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I: C) influenza vaccine

Moriyama, M., Takeyama, H., Hasegawa, H. & Ichinohe, T., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Massively parallel whole genome amplification for single-cell sequencing using droplet microfluidics

Hosokawa, M., Nishikawa, Y., Kogawa, M. & Takeyama, H., 2017 Dec 1, In : Scientific reports. 7, 1, 5199.

Research output: Contribution to journalArticle

32 Citations (Scopus)

On-site Direct Detection of Astaxanthin from Salmon Fillet Using Raman Spectroscopy

Hikima, J. I., Ando, M., Hamaguchi, H. O., Sakai, M., Maita, M., Yazawa, K., Takeyama, H. & Aoki, T., 2017 Apr 1, In : Marine Biotechnology. 19, 2, p. 157-163 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

SAG-QC: Quality control of single amplified genome information by subtracting non-target sequences based on sequence compositions

Maruyama, T., Mori, T., Yamagishi, K. & Takeyama, H., 2017 Mar 4, In : BMC Bioinformatics. 18, 1, 152.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Site-specific gene expression analysis using an automated tissue micro-dissection punching system

Yoda, T., Hosokawa, M., Takahashi, K., Sakanashi, C., Takeyama, H. & Kambara, H., 2017 Dec 1, In : Scientific Reports. 7, 1, 4325.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Transcriptome analysis of immune response against Vibrio harveyi infection in orange-spotted grouper (Epinephelus coioides)

Maekawa, S., Byadgi, O., Chen, Y. C., Aoki, T., Takeyama, H., Yoshida, T., Hikima, J. I., Sakai, M., Wang, P. C. & Chen, S. C., 2017 Nov 1, In : Fish and Shellfish Immunology. 70, p. 628-637 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Whole-genome sequence of Photobacterium damselae subsp. piscicida strain 91-197, isolated from hybrid striped bass (Morone sp.) in the United States

Teru, Y., Hikima, J. I., Kono, T., Sakai, M., Takano, T., Hawke, J. P., Takeyama, H. & Aoki, T., 2017 Jul 1, In : Genome Announcements. 5, 29, e00600-17.

Research output: Contribution to journalArticle

2016

Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor

Brandstätter, O., Schanz, O., Vorac, J., König, J., Mori, T., Maruyama, T., Korkowski, M., Haarmann-Stemmann, T., Von Smolinski, D., Schultze, J. L., Abel, J., Esser, C., Takeyama, H., Weighardt, H. & Förster, I., 2016 May 17, In : Scientific Reports. 6, 26091.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus

Saga, R., Fujimoto, A., Watanabe, N., Matsuda, M., Hasegawa, M., Watashi, K., Aizaki, H., Nakamura, N., Tajima, S., Takasaki, T., Konishi, E., Kato, T., Kohara, M., Takeyama, H., Wakita, T. & Suzuki, R., 2016 Jun 27, In : Scientific reports. 6, 28688.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of a novel gene involved in cadmium accumulation screened from sponge-associated bacterial metagenome

Mori, T., Iwamoto, K., Wakaoji, S., Araie, H., Kohara, Y., Okamura, Y., Shiraiwa, Y. & Takeyama, H., 2016 Feb 1, In : Gene. 576, 2, p. 618-625 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Draft genome sequence of the fish pathogen Mycobacterium pseudoshottsii strain JCM15466, a species closely related to M. marinum

Hikima, J. I., Sakai, M., Aoki, T., Takeyama, H., Hawke, J., Mori, K., Tashiro, K. & Kuhara, S., 2016, In : Genome Announcements. 4, 1, e01630-15.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Falsirhodobacter sp. alg1 Harbors Single Homologs of Endo and Exo-Type Alginate Lyases Efficient for Alginate Depolymerization

Mori, T., Takahashi, M., Tanaka, R., Miyake, H., Shibata, T., Chow, S., Kuroda, K., Ueda, M. & Takeyama, H., 2016 May 1, In : PLoS One. 11, 5, e0155537.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Homeostatically maintained resting naive CD4+ T cells resist latent HIV reactivation

Tsunetsugu-Yokota, Y., Kobayahi-Ishihara, M., Wada, Y., Terahara, K., Takeyama, H., Kawana-Tachikawa, A., Tokunaga, K., Yamagishi, M., Martinez, J. P. & Meyerhans, A., 2016, In : Frontiers in Microbiology. 7, DEC, 1944.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine

Saito, S., Ainai, A., Suzuki, T., Harada, N., Ami, Y., Yuki, Y., Takeyama, H., Kiyono, H., Tsukada, H. & Hasegawa, H., 2016 Feb 24, In : Vaccine. 34, 9, p. 1201-1207 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The RNA- and TRIM25-binding domains of influenza virus NS1 protein are essential for suppression of NLRP3 inflammasomemediated interleukin-1β secretion

Moriyama, M., Chen, I. Y., Kawaguchi, A., Koshiba, T., Nagata, K., Takeyama, H., Hasegawa, H. & Ichinohe, T., 2016 Apr 1, In : Journal of Virology. 90, 8, p. 4105-4114 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2015

Analysis of bacterial xylose isomerase gene diversity using gene-targeted metagenomics

Nurdiani, D., Ito, M., Maruyama, T., Terahara, T., Mori, T., Ugawa, S. & Takeyama, H., 2015 Aug 1, In : Journal of Bioscience and Bioengineering. 120, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)