• 5621 Citations
  • 35 h-Index
1984 …2019

Research output per year

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Research Output

  • 5621 Citations
  • 35 h-Index
  • 95 Article
  • 9 Review article
  • 2 Comment/debate
  • 1 Editorial
2019

A method of producing genetically manipulated mouse mammary gland

Tagaya, H., Ishikawa, K., Hosokawa, Y., Kobayashi, S., Ueoka, Y., Shimada, M., Ohashi, Y., Mikami, H., Yamamoto, M., Ihara, T., Kumazawa, K., Sugihara, K., Goshima, N., Watanabe, S. & Senba, K., 2019 Jan 5, In : Breast cancer research : BCR. 21, 1, 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells

Maekawa, M., Hiyoshi, H., Nakayama, J., Kido, K., Sawasaki, T., Semba, K., Kubota, E., Joh, T. & Higashiyama, S., 2019 Sep 3, In : Biochemical and Biophysical Research Communications. 516, 4, p. 1116-1122 7 p.

Research output: Contribution to journalArticle

Open Access

Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells

Murakami, A., Maekawa, M., Kawai, K., Nakayama, J., Araki, N., Semba, K., Taguchi, T., Kamei, Y., Takada, Y. & Higashiyama, S., 2019 Feb 1, In : Cancer Science. 110, 2, p. 650-661 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Genetic manipulation of the mammary gland and potential applications

Tagaya, H., Semba, K. & Ishikawa, K., 2019 Jan 1, In : Oncotarget. 10, 42, p. 4253-4254 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9

Tanigawa, K., Maekawa, M., Kiyoi, T., Nakayama, J., Kitazawa, R., Kitazawa, S., Semba, K., Taguchi, T., Akita, S., Yoshida, M., Ishimaru, K., Watanabe, Y. & Higashiyama, S., 2019 Oct, In : Journal of Cellular Physiology. 234, 10, p. 17280-17294 15 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion

Yamamoto, M., Abe, C., Wakinaga, S., Sakane, K., Yumiketa, Y., Taguchi, Y., Matsumura, T., Ishikawa, K., Fujimoto, J., Semba, K., Miyauchi, M., Akiyama, T. & Inoue, J. I., 2019 Dec 1, In : Communications Biology. 2, 1, 292.

Research output: Contribution to journalArticle

Open Access
2018

Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines

Namatame, N., Tamaki, N., Yoshizawa, Y., Okamura, M., Nishimura, Y., Yamazaki, K., Tanaka, M., Nakamura, T., Senba, K., Yamori, T., Yaguchi, S. I. & Dan, S., 2018 Oct 1, In : Oncotarget. 9, 80, p. 35141-35161 21 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

PHLDA1, another PHLDA family protein that inhibits Akt

Chen, Y., Takikawa, M., Tsutsumi, S., Yamaguchi, Y., Okabe, A., Shimada, M., Kawase, T., Sada, A., Ezawa, I., Takano, Y., Nagata, K., Suzuki, Y., Senba, K., Aburatani, H. & Ohki, R., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection

Nakayama, J., Ito, E., Fujimoto, J., Watanabe, S. & Senba, K., 2017 Feb 1, In : International Journal of Oncology. 50, 2, p. 497-504 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
14 Citations (Scopus)

Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation

Hoshi, H., Hiyama, G., Ishikawa, K., Inageda, K., Fujimoto, J., Wakamatsu, A., Togashi, T., Kawamura, Y., Takahashi, N., Higa, A., Goshima, N., Senba, K., Watanabe, S. & Takagi, M., 2017 Jan 1, In : Oncology Reports. 37, 1, p. 66-76 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

Matsudaira, T., Mukai, K., Noguchi, T., Hasegawa, J., Hatta, T., Iemura, S. I., Natsume, T., Miyamura, N., Nishina, H., Nakayama, J., Semba, K., Tomita, T., Murata, S., Arai, H. & Taguchi, T., 2017 Dec 1, In : Nature communications. 8, 1, 1246.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer

Yamamoto, M., Sakane, K., Tominaga, K., Gotoh, N., Niwa, T., Kikuchi, Y., Tada, K., Goshima, N., Senba, K. & Inoue, J. I., 2017 Jun 1, In : Cancer Science. 108, 6, p. 1210-1222 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

Okita, Y., Kimura, M., Xie, R., Chen, C., Shen, L. T. W., Kojima, Y., Suzuki, H., Muratani, M., Saitoh, M., Senba, K., Heldin, C. H. & Kato, M., 2017 Apr 11, In : Science Signaling. 10, 474

Research output: Contribution to journalArticle

15 Citations (Scopus)

Type i neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice

Arai, T., Ono, Y., Arimura, Y., Sayama, K., Suzuki, T., Shinjo, S., Kanai, M., Abe, S. I., Senba, K. & Goda, N., 2017 Feb 20, In : Scientific Reports. 7, 42959.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

An in vivo screening system to identify tumorigenic genes

Ihara, T., Hosokawa, Y., Kumazawa, K., Ishikawa, K., Fujimoto, J., Yamamoto, M., Muramkami, T., Goshima, N., Ito, E., Watanabe, S. & Senba, K., 2016 Oct 3, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Matsui, A., Fujimoto, J., Ishikawa, K., Ito, E., Goshima, N., Watanabe, S. & Senba, K., 2016 Apr 1, In : FEBS Letters. 590, 8, p. 1211-1221 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

Asano, Y., Kawase, T., Okabe, A., Tsutsumi, S., Ichikawa, H., Tatebe, S., Kitabayashi, I., Tashiro, F., Namiki, H., Kondo, T., Senba, K., Aburatani, H., Taya, Y., Nakagama, H. & Ohki, R., 2016 Jan 12, In : Scientific Reports. 6, 19174.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells

Ezawa, I., Sawai, Y., Kawase, T., Okabe, A., Tsutsumi, S., Ichikawa, H., Kobayashi, Y., Tashiro, F., Namiki, H., Kondo, T., Senba, K., Aburatani, H., Taya, Y., Nakagama, H. & Ohki, R., 2016 Jun 1, In : Cancer Science. 107, 6, p. 734-745 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2015

Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures

Doi, A., Ishikawa, K., Shibata, N., Ito, E., Fujimoto, J., Yamamoto, M., Shiga, H., Mochizuki, H., Kawamura, Y., Goshima, N., Semba, K. & Watanabe, S., 2015 Feb 1, In : Molecular Oncology. 9, 2, p. 355-364 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia

Yamauchi, H., Matsumaru, T., Morita, T., Ishikawa, S., Maenaka, K., Takigawa, I., Senba, K., Kon, S. & Fujita, Y., 2015 Oct 20, In : Scientific Reports. 5, 15336.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth

Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T., Seiki, M. & Inoue, J. I., 2015 Jan 1, In : Cancer Research. 75, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

δNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines

Amin, R., Morita-Fujimura, Y., Tawarayama, H., Senba, K., Chiba, N., Fukumoto, M. & Ikawa, S., 2015 Sep 22, (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation

Ishikawa, K., Ito, K., Inoue, J. I. & Semba, K., 2013 Oct 1, In : Genes to Cells. 18, 10, p. 859-872 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Gene amplification: Mechanisms and involvement in cancer

Matsui, A., Ihara, T., Suda, H., Mikami, H. & Semba, K., 2013 Dec 1, In : Biomolecular Concepts. 4, 6, p. 567-582 16 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes

Shirakihara, T., Kawasaki, T., Fukagawa, A., Semba, K., Sakai, R., Miyazono, K., Miyazawa, K. & Saitoh, M., 2013 Sep 1, In : Cancer Science. 104, 9, p. 1189-1197 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

Yamamoto, M., Taguchi, Y., Ito-Kureha, T., Semba, K., Yamaguchi, N. & Inoue, J. I., 2013 Sep 2, In : Nature communications. 4, 2299.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

Yoshikawa, S., Kukimoto-Niino, M., Parker, L., Handa, N., Terada, T., Fujimoto, T., Terazawa, Y., Wakiyama, M., Sato, M., Sano, S., Kobayashi, T., Tanaka, T., Chen, L., Liu, Z. J., Wang, B. C., Shirouzu, M., Kawa, S., Semba, K., Yamamoto, T. & Yokoyama, S., 2013 Jan 3, In : Oncogene. 32, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2012

CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/80- Cells and Promotes Tumor Progression

Matsui, A., Yokoo, H., Negishi, Y., Endo-Takahashi, Y., Chun, N. A. L., Kadouchi, I., Suzuki, R., Maruyama, K., Aramaki, Y., Semba, K., Kobayashi, E., Takahashi, M. & Murakami, T., 2012 Aug 29, In : PloS one. 7, 8, e44080.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene

Saito, M., Kato, Y., Ito, E., Fujimoto, J., Ishikawa, K., Doi, A., Kumazawa, K., Matsui, A., Takebe, S., Ishida, T., Azuma, S., Mochizuki, H., Kawamura, Y., Yanagisawa, Y., Honma, R., Imai, J. I., Ohbayashi, H., Goshima, N., Semba, K. & Watanabe, S., 2012 Jun 12, In : FEBS Letters. 586, 12, p. 1708-1714 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Potential anti-tumor effect of IFN-λ2 (IL-28A) against human lung cancer cells

Tezuka, Y., Endo, S., Matsui, A., Sato, A., Saito, K., Semba, K., Takahashi, M. & Murakami, T., 2012 Dec 1, In : Lung Cancer. 78, 3, p. 185-192 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TGF-Β drives epithelial-mesenchymal transition through EF1-mediated downregulation of ESRP

Horiguchi, K., Sakamoto, K., Koinuma, D., Semba, K., Inoue, A., Inoue, S., Fujii, H., Yamaguchi, A., Miyazawa, K., Miyazono, K. & Saitoh, M., 2012 Jun 28, In : Oncogene. 31, 26, p. 3190-3201 12 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)
2010

Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer

Yamamoto, M., Ito, T., Shimizu, T., Ishida, T., Semba, K., Watanabe, S., Yamaguchi, N. & Inoue, J. I., 2010 Nov 1, In : Cancer Science. 101, 11, p. 2391-2397 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Identification of BCAP-L as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics

Matsumura, T., Oyama, M., Kozuka-Hata, H., Ishikawa, K., Inoue, T., Muta, T., Semba, K. & Inoue, J. I., 2010 Sep 1, In : Biochemical and Biophysical Research Communications. 400, 2, p. 265-270 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Phosphoproteomics-Based modeling defines the regulatory mechanism underlying aberrant EGFR signaling

Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J. I., Yamamoto, T., Miyano, S., Sugano, S. & Oyama, M., 2010 Dec 9, In : PloS one. 5, 11, e13926.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2009

A novel mouse monoclonal antibody targeting ErbB2 suppresses breast cancer growth

Kawa, S., Matsushita, H., Ohbayashi, H., Semba, K. & Yamamoto, T., 2009 Jul 3, In : Biochemical and Biophysical Research Communications. 384, 3, p. 329-333 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Constitutive activation of nuclear factor-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines

Yamaguchi, N., Ito, T., Azuma, S., Ito, E., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J. I., Watanabe, S., Semba, K. & Inoue, J. I., 2009 Sep 1, In : Cancer Science. 100, 9, p. 1668-1674 7 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells

Ishikawa, K., Akiyama, T., Ito, K., Semba, K. & Inoue, J. I., 2009 Dec 18, In : Biochemical and Biophysical Research Communications. 390, 3, p. 552-556 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells

Nishina, T., Yamaguchi, N., Gohda, J., Semba, K. & Inoue, J. I., 2009 Oct 9, In : Biochemical and Biophysical Research Communications. 388, 1, p. 96-101 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks

Oyama, M., Kozuka-Hata, H., Tasaki, S., Semba, K., Hattori, S., Sugano, S., Inoue, J. I. & Yamamoto, T., 2009 Feb 1, In : Molecular and Cellular Proteomics. 8, 2, p. 226-231 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H., Yamamoto, T., Yamazaki, K., Gohda, J., Akiyama, T., Semba, K., Goto, H., Kato, A., Yujiri, T., Imai, T., Kawaguchi, Y., Su, B., Takeuchi, O., Akira, S., Tsunetsugu-Yokota, Y. & Inoue, J. I., 2009 May 25, In : PloS one. 4, 5, e5674.

Research output: Contribution to journalArticle

64 Citations (Scopus)

TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions.

Matsumura, T., Kawamura-Tsuzuku, J., Yamamoto, T., Semba, K. & Inoue, J. I., 2009 Sep, In : Journal of biochemistry. 146, 3, p. 375-381 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2008

Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin

Haraguchi, K., Ohsugi, M., Abe, Y., Semba, K., Akiyama, T. & Yamamoto, T., 2008 Jan 10, In : Oncogene. 27, 3, p. 274-284 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Yamaguchi, N., Ito, E., Azuma, S., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J. I., Tatsuta, K., Inoue, J. I., Semba, K. & Watanabe, S., 2008 Jan 25, In : Biochemical and Biophysical Research Communications. 365, 4, p. 711-717 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex

Miyasaka, T., Morita, M., Ito, K., Suzuki, T., Fukuda, H., Takeda, S., Inoue, J. I., Semba, K. & Yamamoto, T., 2008 Apr 1, In : Cancer Science. 99, 4, p. 755-761 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells

Yamaguchi, N., Oyama, T., Ito, E., Satoh, H., Azuma, S., Hayashi, M., Shimizu, K., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J. I., Ohwada, S., Tatsuta, K., Inoue, J. I., Semba, K. & Watanabe, S., 2008 Mar 15, In : Cancer Research. 68, 6, p. 1881-1888 8 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)
2007

AYUMS: An algorithm for completely automatic quantitation based on LC-MS/ MS proteome data and its application to the analysis of signal transduction

Saito, A., Nagasaki, M., Oyama, M., Kozuka-Hata, H., Semba, K., Sugano, S., Yamamoto, T. & Miyano, S., 2007 Feb 19, In : BMC Bioinformatics. 8, 15.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Diversity of transplantation start sites may define increased complexity of the human short ORFeome

Oyama, M., Kozuka-Hata, H., Suzuki, Y., Semba, K., Yamamoto, T. & Sugano, S., 2007 Jun 1, In : Molecular and Cellular Proteomics. 6, 6, p. 1000-1006 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

NF-κB activation in development and progression of cancer

Inoue, J. I., Gohda, J., Akiyama, T. & Semba, K., 2007 Mar 1, In : Cancer Science. 98, 3, p. 268-274 7 p.

Research output: Contribution to journalReview article

185 Citations (Scopus)

Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Ito, E., Honma, R., Yanagisawa, Y., Imai, J. I., Azuma, S., Oyama, T., Ohwada, S., Akiyama, T., Nomura, N., Inoue, J. I., Watanabe, S. & Semba, K., 2007 Aug 21, In : FEBS Letters. 581, 21, p. 3909-3914 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)