• 2115 Citations
  • 26 h-Index
1981 …2020

Research output per year

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Research Output

2020

Chemoenzymatic oxygenation method for sesquiterpenoid synthesis based on Fe-chelate and ferric-chelate reductase

Umezawa, S., Akao, H., Kubota, M. & Kino, K., 2020 Apr 2, In : Bioscience, Biotechnology and Biochemistry. 84, 4, p. 780-788 9 p.

Research output: Contribution to journalArticle

Efficient and long-term vanillin production from 4-vinylguaiacol using immobilized whole cells expressing Cso2 protein

Saito, T., Aono, R., Furuya, T. & Kino, K., 2020 Sep, In : Journal of Bioscience and Bioengineering. 130, 3, p. 260-264 5 p.

Research output: Contribution to journalArticle

Enzymatic reactions and microorganisms producing the various isomers of hydroxyproline

Hara, R. & Kino, K., 2020 Jun 1, In : Applied Microbiology and Biotechnology. 104, 11, p. 4771-4779 9 p.

Research output: Contribution to journalReview article

Screening, gene cloning, and characterization of orsellinic acid decarboxylase from Arthrobacter sp. K8 for regio-selective carboxylation of resorcinol derivatives

Kino, K., Hirokawa, Y., Gawasawa, R., Murase, R., Tsuchihashi, R. & Hara, R., 2020 Nov 10, In : Journal of Biotechnology. 323, p. 128-135 8 p.

Research output: Contribution to journalArticle

2019
1 Citation (Scopus)

Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards l-proline

Hara, R., Nishikawa, T., Okuhara, T., Koketsu, K. & Kino, K., 2019 Jan 1, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Isolation and characterization of Gram-negative and Gram-positive bacteria capable of producing piceatannol from resveratrol

Furuya, T., Imaki, N., Shigei, K., Sai, M. & Kino, K., 2019 Jul 20, In : Applied Microbiology and Biotechnology. 103, 14, p. 5811-5820 10 p.

Research output: Contribution to journalArticle

Synthesis of D-amino acid-containing dipeptides using the adenylation domains of nonribosomal peptide synthetase

Kano, S., Suzuki, S., Hara, R. & Kino, K., 2019 Jan 1, In : Applied and Environmental Microbiology. 85, 13, e00120-19.

Research output: Contribution to journalArticle

2018

A chemoenzymatic process for amide bond formation by an adenylating enzyme-mediated mechanism

Hara, R., Hirai, K., Suzuki, S. & Kino, K., 2018 Dec 1, In : Scientific reports. 8, 1, 2950.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Efficient monooxygenase-catalyzed piceatannol production: Application of cyclodextrins for reducing product inhibition

Furuya, T., Sai, M. & Kino, K., 2018 Jan 1, (Accepted/In press) In : Journal of Bioscience and Bioengineering.

Research output: Contribution to journalArticle

4 Citations (Scopus)
4 Citations (Scopus)

Structural polymorphism of the Escherichia coli poly-α-L-glutamate synthetase RimK

Arimura, Y., Kono, T., Kino, K. & Kurumizaka, H., 2018 Jul 1, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 7, p. 385-390 6 p.

Research output: Contribution to journalArticle

2017

Biotechnological production of vanillin using immobilized enzymes

Furuya, T., Kuroiwa, M. & Kino, K., 2017 Feb 10, In : Journal of Biotechnology. 243, p. 25-28 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Discovery of lysine hydroxylases in the clavaminic acid synthase-like superfamily for efficient hydroxylysine bioproduction

Hara, R., Yamagata, K., Miyake, R., Kawabata, H., Uehara, H. & Kino, K., 2017 Sep 1, In : Applied and Environmental Microbiology. 83, 17, e00693-17.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016
7 Citations (Scopus)

Development of a multi-enzymatic cascade reaction for the synthesis of trans-3-hydroxy-l-proline from l-arginine

Hara, R., Kitatsuji, S., Yamagata, K. & Kino, K., 2016 Jan 1, In : Applied Microbiology and Biotechnology. 100, 1, p. 243-253 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Effective production of Pro-Gly by mutagenesis of l-amino acid ligase

Kino, H., Nakajima, S., Arai, T. & Kino, K., 2016 Aug 1, In : Journal of Bioscience and Bioengineering. 122, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase

Watanabe, S., Tajima, K., Fujii, S., Fukumori, F., Hara, R., Fukuda, R., Miyazaki, M., Kino, K. & Watanabe, Y., 2016 Dec 8, In : Scientific reports. 6, 38720.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Alteration of the substrate specificity of cytochrome P450 CYP199A2 by site-directed mutagenesis

Furuya, T., Shitashima, Y. & Kino, K., 2015 Jan 1, In : Journal of Bioscience and Bioengineering. 119, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
7 Citations (Scopus)

Catalytic function of the mycobacterial binuclear iron monooxygenase in acetone metabolism

Furuya, T., Nakao, T. & Kino, K., 2015 Aug 31, In : FEMS Microbiology Letters. 362, 19, fnv136.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Enzymatic carboxylation of hydroxystilbenes by the γ-resorcylic acid decarboxylase from Rhizobium radiobacter WU-0108 under reverse reaction conditions

Sato, M., Sakurai, N., Suzuki, H., Shibata, D. & Kino, K., 2015 Dec 1, In : Journal of Molecular Catalysis B: Enzymatic. 122, p. 348-352 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

High-yield production of vanillin from ferulic acid by a coenzyme-independent decarboxylase/oxygenase two-stage process

Furuya, T., Miura, M., Kuroiwa, M. & Kino, K., 2015 May 5, In : New Biotechnology. 32, 3, p. 335-339 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Hydroxamate-based colorimetric assay to assess amide bond formation by adenylation domain of nonribosomal peptide synthetases

Hara, R., Suzuki, R. & Kino, K., 2015 May 15, In : Analytical Biochemistry. 477, p. 89-91 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
3 Citations (Scopus)

Refined regio- and stereoselective hydroxylation of l -pipecolic acid by protein engineering of l -proline cis -4-hydroxylase based on the X-ray crystal structure

Koketsu, K., Shomura, Y., Moriwaki, K., Hayashi, M., Mitsuhashi, S., Hara, R., Kino, K. & Higuchi, Y., 2015 Apr 17, In : ACS Synthetic Biology. 4, 4, p. 383-392 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Screening of salt taste enhancing dipeptides based on a new strategy using L-amino acid ligase

Kino, H., Kakutani, M., Hattori, K., Tojo, H., Komai, T., Nammoku, T. & Kino, K., 2015 May 1, In : Nippon Shokuhin Kagaku Kogaku Kaishi. 62, 6, p. 274-281 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structure of RizA, an l-amino-acid ligase from Bacillus subtilis

Kagawa, W., Arai, T., Ishikura, S., Kino, K. & Kurumizaka, H., 2015 Sep 1, In : Acta Crystallographica Section:F Structural Biology Communications. 71, p. 1125-1130 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

A coenzyme-independent decarboxylase/oxygenase cascade for the efficient synthesis of vanillin

Furuya, T., Miura, M. & Kino, K., 2014 Oct 13, In : Chembiochem : a European journal of chemical biology. 15, 15, p. 2248-2254 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
34 Citations (Scopus)
8 Citations (Scopus)

Regio- and stereoselective oxygenation of proline derivatives by using microbial 2-oxoglutarate-dependent dioxygenases

Hara, R., Uchiumi, N., Okamoto, N. & Kino, K., 2014, In : Bioscience, Biotechnology, and Biochemistry. 78, 8, p. 1384-1388 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Furuya, T. & Kino, K., 2014 Apr 23, In : Tetrahedron Letters. 55, 17, p. 2853-2855 3 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2013

Application of protein N-terminal amidase in enzymatic synthesis of dipeptides containing acidic amino acids specifically at the N-terminus

Arai, T., Noguchi, A., Takano, E. & Kino, K., 2013 Apr 1, In : Journal of Bioscience and Bioengineering. 115, 4, p. 382-387 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Biocatalytic production of 5-hydroxy-2-adamantanone by P450cam coupled with NADH regeneration

Furuya, T., Kanno, T., Yamamoto, H., Kimoto, N., Matsuyama, A. & Kino, K., 2013 Jan 1, In : Journal of Molecular Catalysis B: Enzymatic. 94, p. 111-118 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Construction of photoenergetic mitochondria in cultured mammalian cells

Hara, K. Y., Wada, T., Kino, K., Asahi, T. & Sawamura, N., 2013 Apr 9, In : Scientific reports. 3, 1635.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Enhanced synthesis of 5-Hydroxy-L-tryptophan through tetrahydropterin regeneration

Hara, R. & Kino, K., 2013, In : AMB Express. 3, p. 1-7 7 p., 70.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Enzymatic production of designed peptide

Kino, K., 2013 Nov 1, Microbial Production: From Genome Design to Cell Engineering. Springer Japan, Vol. 9784431546078. p. 191-204 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

L-Amino acid ligase from Pseudomonas syringae producing tabtoxin can be used for enzymatic synthesis of various functional peptides

Arai, T., Arimura, Y., Ishikura, S. & Kino, K., 2013 Aug, In : Applied and Environmental Microbiology. 79, 16, p. 5023-5029 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Microbial production of N-acetyl cis-4-hydroxy-l-proline by coexpression of the Rhizobium l-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1

Bach, T. M. H., Hara, R., Kino, K., Ohtsu, I., Yoshida, N. & Takagi, H., 2013 Jan 1, In : Applied Microbiology and Biotechnology. 97, 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s

Hamano, Y., Arai, T., Ashiuchi, M. & Kino, K., 2013, In : Natural Product Reports. 30, 8, p. 1087-1097 11 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Reconstitution of active mycobacterial binuclear iron monooxygenase complex in escherichia coli

Furuya, T., Hayashi, M. & Kino, K., 2013 Sep 20, In : Applied and Environmental Microbiology. 79, 19, p. 6033-6039 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The mycobacterial binuclear iron monooxygenases require a specific chaperonin-like protein for functional expression in a heterologous host

Furuya, T., Hayashi, M., Semba, H. & Kino, K., 2013 Feb, In : FEBS Journal. 280, 3, p. 817-826 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Biotechnological production of caffeic acid by bacterial cytochrome P450 CYP199A2

Furuya, T., Arai, Y. & Kino, K., 2012 Sep, In : Applied and Environmental Microbiology. 78, 17, p. 6087-6094 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents

Kagebayashi, T., Kontani, N., Yamada, Y., Mizushige, T., Arai, T., Kino, K. & Ohinata, K., 2012 Sep 1, In : Molecular Nutrition and Food Research. 56, 9, p. 1456-1463 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Purification, characterization, and gene identification of an α-glucosyl transfer enzyme, a novel type α-glucosidase from Xanthomonas campestris WU-9701

Sato, T., Hasegawa, N., Saito, J., Umezawa, S., Honda, Y., Kino, K. & Kirimura, K., 2012 Aug 1, In : Journal of Molecular Catalysis B: Enzymatic. 80, p. 20-27 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The structure of l-amino-acid ligase from Bacillus licheniformis

Suzuki, M., Takahashi, Y., Noguchi, A., Arai, T., Yagasaki, M., Kino, K. & Saito, J. I., 2012 Nov 1, In : Acta Crystallographica Section D: Biological Crystallography. 68, 11, p. 1535-1540 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

ATP Photosynthetic vesicles for light-driven bioprocesses

Hara, K. Y., Suzuki, R., Suzuki, T., Yoshida, M. & Kino, K., 2011 Jun 1, In : Biotechnology Letters. 33, 6, p. 1133-1138 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria

Furuya, T., Hirose, S., Osanai, H., Semba, H. & Kino, K., 2011 Feb 1, In : Applied and Environmental Microbiology. 77, 4, p. 1214-1220 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Identification of the regulator gene responsible for the acetone-responsive expression of the binuclear iron monooxygenase gene cluster in mycobacteria

Furuya, T., Hirose, S., Semba, H. & Kino, K., 2011 Oct, In : Journal of Bacteriology. 193, 20, p. 5817-5823 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)