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Research Output 1981 2019

  • 1900 Citations
  • 25 h-Index
  • 112 Article
  • 2 Chapter
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2019

Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards l-proline

Hara, R., Nishikawa, T., Okuhara, T., Koketsu, K. & Kino, K., 2019 Jan 1, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journalArticle

Hydroxylation
Mixed Function Oxygenases
Proline
Enzymes
Halomonas

Isolation and characterization of Gram-negative and Gram-positive bacteria capable of producing piceatannol from resveratrol

Furuya, T., Imaki, N., Shigei, K., Sai, M. & Kino, K., 2019 Jan 1, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journalArticle

Gram-Positive Bacteria
Hydroxylation
Carbon
Growth
Arthrobacter

Synthesis of D-amino acid-containing dipeptides using the adenylation domains of nonribosomal peptide synthetase

Kano, S., Suzuki, S., Hara, R. & Kino, K., 2019 Jan 1, In : Applied and Environmental Microbiology. 85, 13, e00120-19.

Research output: Contribution to journalArticle

Peptide Synthases
dipeptides
Dipeptides
ligases
peptide
2018
4 Citations (Scopus)

A chemoenzymatic process for amide bond formation by an adenylating enzyme-mediated mechanism

Hara, R., Hirai, K., Suzuki, S. & Kino, K., 2018 Dec 1, In : Scientific Reports. 8, 1, 2950.

Research output: Contribution to journalArticle

Amides
Enzymes
Tryptophan
Amines
Food additives
4 Citations (Scopus)

Efficient monooxygenase-catalyzed piceatannol production: Application of cyclodextrins for reducing product inhibition

Furuya, T., Sai, M. & Kino, K., 2018 Jan 1, (Accepted/In press) In : Journal of Bioscience and Bioengineering.

Research output: Contribution to journalArticle

Cyclodextrins
Mixed Function Oxygenases
Resveratrol
Stilbenes
Hydroxylation
2 Citations (Scopus)
Peptide Synthases
Adenosinetriphosphate
Proline
Peptides
Regeneration

Structural polymorphism of the Escherichia coli poly-α-L-glutamate synthetase RimK

Arimura, Y., Kono, T., Kino, K. & Kurumizaka, H., 2018 Jul 1, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 7, p. 385-390 6 p.

Research output: Contribution to journalArticle

Glutamate Synthase (NADH)
glutamates
polymorphism
Escherichia
Polymorphism
2017
14 Citations (Scopus)

Biotechnological production of vanillin using immobilized enzymes

Furuya, T., Kuroiwa, M. & Kino, K., 2017 Feb 10, In : Journal of Biotechnology. 243, p. 25-28 4 p.

Research output: Contribution to journalArticle

Immobilized Enzymes
Enzymes
Coenzymes
ferulic acid
isoeugenol
1 Citation (Scopus)

Discovery of lysine hydroxylases in the clavaminic acid synthase-like superfamily for efficient hydroxylysine bioproduction

Hara, R., Yamagata, K., Miyake, R., Kawabata, H., Uehara, H. & Kino, K., 2017 Sep 1, In : Applied and Environmental Microbiology. 83, 17, e00693-17.

Research output: Contribution to journalArticle

2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
hydroxylysine
Hydroxylysine
industrial technology
Lysine
2016
7 Citations (Scopus)
Stilbenes
Mixed Function Oxygenases
Escherichia coli
Mass Spectrometry
Buffers
4 Citations (Scopus)

Development of a multi-enzymatic cascade reaction for the synthesis of trans-3-hydroxy-l-proline from l-arginine

Hara, R., Kitatsuji, S., Yamagata, K. & Kino, K., 2016 Jan 1, In : Applied Microbiology and Biotechnology. 100, 1, p. 243-253 11 p.

Research output: Contribution to journalArticle

ornithine cyclodeaminase
Arginase
Proline
Arginine
Mixed Function Oxygenases
3 Citations (Scopus)

Effective production of Pro-Gly by mutagenesis of l-amino acid ligase

Kino, H., Nakajima, S., Arai, T. & Kino, K., 2016 Aug 1, In : Journal of Bioscience and Bioengineering. 122, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

prolylglycine
Mutagenesis
Ligases
Amino acids
Amino Acids
3 Citations (Scopus)

Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase

Watanabe, S., Tajima, K., Fujii, S., Fukumori, F., Hara, R., Fukuda, R., Miyazaki, M., Kino, K. & Watanabe, Y., 2016 Dec 8, In : Scientific Reports. 6, 38720.

Research output: Contribution to journalArticle

Aconitate Hydratase
Hydro-Lyases
Proline
Hydroxyproline
Cysteine
2015
6 Citations (Scopus)

Alteration of the substrate specificity of cytochrome P450 CYP199A2 by site-directed mutagenesis

Furuya, T., Shitashima, Y. & Kino, K., 2015 Jan 1, In : Journal of Bioscience and Bioengineering. 119, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

Mutagenesis
Substrate Specificity
Site-Directed Mutagenesis
Cytochrome P-450 Enzyme System
Carboxylic acids
5 Citations (Scopus)
methionylglycine
methionylmethionine
Ligases
Substrate Specificity
Salts
3 Citations (Scopus)

Catalytic function of the mycobacterial binuclear iron monooxygenase in acetone metabolism

Furuya, T., Nakao, T. & Kino, K., 2015 Aug 31, In : FEMS Microbiology Letters. 362, 19, fnv136.

Research output: Contribution to journalArticle

Acetone
Iron
Mycobacterium
Escherichia coli
Mycobacterium smegmatis
6 Citations (Scopus)

Enzymatic carboxylation of hydroxystilbenes by the γ-resorcylic acid decarboxylase from Rhizobium radiobacter WU-0108 under reverse reaction conditions

Sato, M., Sakurai, N., Suzuki, H., Shibata, D. & Kino, K., 2015 Dec 1, In : Journal of Molecular Catalysis B: Enzymatic. 122, p. 348-352 5 p.

Research output: Contribution to journalArticle

Resveratrol
Carboxylation
Agrobacterium tumefaciens
Carboxy-Lyases
Benzoic acid
17 Citations (Scopus)

High-yield production of vanillin from ferulic acid by a coenzyme-independent decarboxylase/oxygenase two-stage process

Furuya, T., Miura, M., Kuroiwa, M. & Kino, K., 2015 May 5, In : New Biotechnology. 32, 3, p. 335-339 5 p.

Research output: Contribution to journalArticle

ferulic acid
Coenzymes
Oxygenases
Carboxy-Lyases
Escherichia coli
7 Citations (Scopus)

Hydroxamate-based colorimetric assay to assess amide bond formation by adenylation domain of nonribosomal peptide synthetases

Hara, R., Suzuki, R. & Kino, K., 2015 May 15, In : Analytical Biochemistry. 477, p. 89-91 3 p.

Research output: Contribution to journalArticle

Peptide Synthases
Biosynthesis
Amides
Tyrocidine
Assays
3 Citations (Scopus)
Streptomyces coelicolor
asparaginase
Asparaginase
Asparagine
asparagine
11 Citations (Scopus)

Refined regio- and stereoselective hydroxylation of l -pipecolic acid by protein engineering of l -proline cis -4-hydroxylase based on the X-ray crystal structure

Koketsu, K., Shomura, Y., Moriwaki, K., Hayashi, M., Mitsuhashi, S., Hara, R., Kino, K. & Higuchi, Y., 2015 Apr 17, In : ACS Synthetic Biology. 4, 4, p. 383-392 10 p.

Research output: Contribution to journalArticle

Protein Engineering
Hydroxylation
Mixed Function Oxygenases
Proline
Hydroxyproline
2 Citations (Scopus)

Screening of salt taste enhancing dipeptides based on a new strategy using L-amino acid ligase

Kino, H., Kakutani, M., Hattori, K., Tojo, H., Komai, T., Nammoku, T. & Kino, K., 2015 May 1, In : Nippon Shokuhin Kagaku Kogaku Kaishi. 62, 6, p. 274-281 8 p.

Research output: Contribution to journalArticle

dipeptides
Dipeptides
Ligases
ligases
Salts
3 Citations (Scopus)

Structure of RizA, an l-amino-acid ligase from Bacillus subtilis

Kagawa, W., Arai, T., Ishikura, S., Kino, K. & Kurumizaka, H., 2015 Sep 1, In : Acta Crystallographica Section F:Structural Biology Communications. 71, p. 1125-1130 6 p.

Research output: Contribution to journalArticle

Bacillus
Bacilli
Ligases
Bacillus subtilis
amino acids
2014
14 Citations (Scopus)

A coenzyme-independent decarboxylase/oxygenase cascade for the efficient synthesis of vanillin

Furuya, T., Miura, M. & Kino, K., 2014 Oct 13, In : Chembiochem : a European journal of chemical biology. 15, 15, p. 2248-2254 7 p.

Research output: Contribution to journalArticle

ferulic acid
Oxygenases
Carboxy-Lyases
Coenzymes
Flavor compounds
25 Citations (Scopus)
Mixed Function Oxygenases
Coumaric Acids
Pseudomonas aeruginosa
ferulic acid
Escherichia coli
7 Citations (Scopus)
Dioxygenases
Hydroxylation
Actinobacteria
Proline
Hydroxyproline
6 Citations (Scopus)

Regio- and stereoselective oxygenation of proline derivatives by using microbial 2-oxoglutarate-dependent dioxygenases

Hara, R., Uchiumi, N., Okamoto, N. & Kino, K., 2014, In : Bioscience, Biotechnology, and Biochemistry. 78, 8, p. 1384-1388 5 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxygenation
Proline
Derivatives
Azetidinecarboxylic Acid
19 Citations (Scopus)

Regioselective synthesis of piceatannol from resveratrol: Catalysis by two-component flavin-dependent monooxygenase HpaBC in whole cells

Furuya, T. & Kino, K., 2014 Apr 23, In : Tetrahedron Letters. 55, 17, p. 2853-2855 3 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Catalysis
Stilbenes
Hydroxylation
Derivatives
2013
5 Citations (Scopus)

Application of protein N-terminal amidase in enzymatic synthesis of dipeptides containing acidic amino acids specifically at the N-terminus

Arai, T., Noguchi, A., Takano, E. & Kino, K., 2013 Apr, In : Journal of Bioscience and Bioengineering. 115, 4, p. 382-387 6 p.

Research output: Contribution to journalArticle

amidase
Acidic Amino Acids
Dipeptides
Amino acids
aspartyl-phenylalanine
1 Citation (Scopus)

Biocatalytic production of 5-hydroxy-2-adamantanone by P450cam coupled with NADH regeneration

Furuya, T., Kanno, T., Yamamoto, H., Kimoto, N., Matsuyama, A. & Kino, K., 2013, In : Journal of Molecular Catalysis B: Enzymatic. 94, p. 111-118 8 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
NAD
Glucose
Regeneration
Glucose 1-Dehydrogenase
11 Citations (Scopus)

Construction of photoenergetic mitochondria in cultured mammalian cells.

Hara, K. Y., Wada, T., Kino, K., Asahi, T. & Sawamura, N., 2013, In : Scientific Reports. 3, p. 1635 1 p.

Research output: Contribution to journalArticle

Proton-Motive Force
Cultured Cells
Mitochondria
Rhodopsin
Proton Pumps
8 Citations (Scopus)

Enhanced synthesis of 5-Hydroxy-L-tryptophan through tetrahydropterin regeneration

Hara, R. & Kino, K., 2013, In : AMB Express. 3, p. 1-7 7 p.

Research output: Contribution to journalArticle

5-Hydroxytryptophan
Tryptophan
Regeneration
Pterins
Tryptophanase
16 Citations (Scopus)

L-Amino acid ligase from Pseudomonas syringae producing tabtoxin can be used for enzymatic synthesis of various functional peptides

Arai, T., Arimura, Y., Ishikura, S. & Kino, K., 2013 Aug, In : Applied and Environmental Microbiology. 79, 16, p. 5023-5029 7 p.

Research output: Contribution to journalArticle

Pseudomonas syringae
Ligases
ligases
peptide
amino acid
9 Citations (Scopus)

Microbial production of N-acetyl cis-4-hydroxy-l-proline by coexpression of the Rhizobium l-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1

Bach, T. M. H., Hara, R., Kino, K., Ohtsu, I., Yoshida, N. & Takagi, H., 2013 Jan, In : Applied Microbiology and Biotechnology. 97, 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

Rhizobium
Acetyltransferases
Mixed Function Oxygenases
Proline
Yeasts
10 Citations (Scopus)

NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s

Hamano, Y., Arai, T., Ashiuchi, M. & Kino, K., 2013, In : Natural Product Reports. 30, 8, p. 1087-1097 11 p.

Research output: Contribution to journalArticle

Ligases
Amides
Amino Acids
Prostaglandins A
Lysine
5 Citations (Scopus)

Reconstitution of active mycobacterial binuclear iron monooxygenase complex in escherichia coli

Furuya, T., Hayashi, M. & Kino, K., 2013, In : Applied and Environmental Microbiology. 79, 19, p. 6033-6039 7 p.

Research output: Contribution to journalArticle

Mixed Function Oxygenases
Iron
iron
Escherichia coli
oxidation
8 Citations (Scopus)

The mycobacterial binuclear iron monooxygenases require a specific chaperonin-like protein for functional expression in a heterologous host

Furuya, T., Hayashi, M., Semba, H. & Kino, K., 2013 Feb, In : FEBS Journal. 280, 3, p. 817-826 10 p.

Research output: Contribution to journalArticle

Chaperonins
Acinetobacter
Mixed Function Oxygenases
Iron
Genes
2012
27 Citations (Scopus)

Biotechnological production of caffeic acid by bacterial cytochrome P450 CYP199A2

Furuya, T., Arai, Y. & Kino, K., 2012 Sep, In : Applied and Environmental Microbiology. 78, 17, p. 6087-6094 8 p.

Research output: Contribution to journalArticle

caffeic acid
cytochrome P-450
Cytochrome P-450 Enzyme System
cytochrome
mutants
25 Citations (Scopus)

Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents

Kagebayashi, T., Kontani, N., Yamada, Y., Mizushige, T., Arai, T., Kino, K. & Ohinata, K., 2012 Sep, In : Molecular Nutrition and Food Research. 56, 9, p. 1456-1463 8 p.

Research output: Contribution to journalArticle

cholecystokinin
dipeptides
Dipeptides
Cholecystokinin
blood pressure
14 Citations (Scopus)

Purification, characterization, and gene identification of an α-glucosyl transfer enzyme, a novel type α-glucosidase from Xanthomonas campestris WU-9701

Sato, T., Hasegawa, N., Saito, J., Umezawa, S., Honda, Y., Kino, K. & Kirimura, K., 2012 Aug, In : Journal of Molecular Catalysis B: Enzymatic. 80, p. 20-27 8 p.

Research output: Contribution to journalArticle

Xanthomonas campestris
Glucosidases
Maltose
Purification
Enzymes
7 Citations (Scopus)

The structure of l-amino-acid ligase from Bacillus licheniformis

Suzuki, M., Takahashi, Y., Noguchi, A., Arai, T., Yagasaki, M., Kino, K. & Saito, J. I., 2012 Nov, In : Acta Crystallographica Section D: Biological Crystallography. 68, 11, p. 1535-1540 6 p.

Research output: Contribution to journalArticle

Ligases
Dipeptides
Amino Acids
Substrate Specificity
Bacillus licheniformis
2011
3 Citations (Scopus)

ATP Photosynthetic vesicles for light-driven bioprocesses

Hara, K. Y., Suzuki, R., Suzuki, T., Yoshida, M. & Kino, K., 2011 Jun, In : Biotechnology Letters. 33, 6, p. 1133-1138 6 p.

Research output: Contribution to journalArticle

Adenosinetriphosphate
Adenosine Triphosphate
Light
Hexokinase
Rhodopsin
20 Citations (Scopus)

Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria

Furuya, T., Hirose, S., Osanai, H., Semba, H. & Kino, K., 2011 Feb, In : Applied and Environmental Microbiology. 77, 4, p. 1214-1220 7 p.

Research output: Contribution to journalArticle

hydroquinone
Mycobacterium
Mycobacterium smegmatis
Multigene Family
Mixed Function Oxygenases
4 Citations (Scopus)

Identification of the regulator gene responsible for the acetone-responsive expression of the binuclear iron monooxygenase gene cluster in mycobacteria

Furuya, T., Hirose, S., Semba, H. & Kino, K., 2011 Oct, In : Journal of Bacteriology. 193, 20, p. 5817-5823 7 p.

Research output: Contribution to journalArticle

Mycobacterium smegmatis
Regulator Genes
Mycobacterium
Multigene Family
Acetone
13 Citations (Scopus)

Poly-α-glutamic acid synthesis using a novel catalytic activity of Rimk from Escherichia coli K-12

Kino, K., Arai, T. & Arimura, Y., 2011 Mar, In : Applied and Environmental Microbiology. 77, 6, p. 2019-2025 7 p.

Research output: Contribution to journalArticle

polyglutamic acid
Escherichia coli K12
catalytic activity
Glutamic Acid
amino acid

Structure-based modification of D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589 for depsipeptide synthesis

Nakagawa, T., Satake, R., Sato, M. & Kino, K., 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 4, p. 700-704 5 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Depsipeptides
Mutagenesis
Polymers
Substitution reactions
2010
14 Citations (Scopus)

A novel L-amino acid ligase from bacillus subtilis NBRC3134 catalyzed oligopeptide synthesis

Kino, K., Arai, T. & Tateiwa, D., 2010, In : Bioscience, Biotechnology and Biochemistry. 74, 1, p. 129-134 6 p.

Research output: Contribution to journalArticle

Oligopeptides
Bacilli
Ligases
Bacillus subtilis
Amino Acids
28 Citations (Scopus)

Genome mining approach for the discovery of novel cytochrome P450 biocatalysts

Furuya, T. & Kino, K., 2010 Apr, In : Applied Microbiology and Biotechnology. 86, 4, p. 991-1002 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Genome
Enzymes
Microbial Genome
Oxygen
9 Citations (Scopus)

Identification and characterization of a novel l-amino acid ligase from Photorhabdus luminescens subsp. laumondii TT01

Kino, K., Noguchi, A., Arai, T. & Yagasaki, M., 2010 Jul, In : Journal of Bioscience and Bioengineering. 110, 1, p. 39-41 3 p.

Research output: Contribution to journalArticle

Photorhabdus
Ligases
Amino acids
Dipeptides
Amino Acids
13 Citations (Scopus)

New L-Amino acid ligases catalyzing oligopeptide synthesis from various microorganisms

Arai, T. & Kino, K., 2010, In : Bioscience, Biotechnology and Biochemistry. 74, 8, p. 1572-1577 6 p.

Research output: Contribution to journalArticle

Oligopeptides
Ligases
Microorganisms
Amino Acids
Proteins