Naoya Sawamura

上級研究員(研究院教授)

  • 2097 Citations
  • 21 h-Index
1994 …2020

Research output per year

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Research Output

  • 2097 Citations
  • 21 h-Index
  • 38 Article
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Short survey
2020

Mammalian cell cultivation using nutrients extracted from microalgae

Okamoto, Y., Haraguchi, Y., Sawamura, N., Asahi, T. & Shimizu, T., 2020 Mar 1, In : Biotechnology Progress. 36, 2, e2941.

Research output: Contribution to journalArticle

2019

Data for positive selection test and co-evolutionary analysis on mammalian cereblon

Onodera, W., Asahi, T. & Sawamura, N., 2019 Oct 1, In : Data in Brief. 26, 104499.

Research output: Contribution to journalArticle

Open Access

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease

Imai, Y., Inoshita, T., Meng, H., Shiba-Fukushima, K., Hara, K. Y., Sawamura, N. & Hattori, N., 2019 Dec 1, In : Communications Biology. 2, 1, 424.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
1 Citation (Scopus)
2018

Antioxidant activity of Ge-132, a synthetic organic germanium, on cultured mammalian cells

Wada, T., Hanyu, T., Nozaki, K., Kataoka, K., Kawatani, T., Asahi, T. & Sawamura, N., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 5, p. 749-753 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cholinergic receptor, nicotinic, alpha 7 as a target molecule of Arctic mutant amyloid β

Sawamura, N., Ju, Y. & Asahi, T., 2018 Aug 1, In : Neural Regeneration Research. 13, 8, p. 1360-1361 2 p.

Research output: Contribution to journalShort survey

The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity

Sawamura, N., Yamada, M., Fujiwara, M., Yamada, H., Hayashi, H., Takagi, N. & Asahi, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 2459.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017
4 Citations (Scopus)
2016

Mitochondrial cereblon functions as a Lon-type protease

Kataoka, K., Nakamura, C., Asahi, T. & Sawamura, N., 2016 Jul 15, In : Scientific Reports. 6, 29986.

Research output: Contribution to journalArticle

8 Citations (Scopus)
7 Citations (Scopus)

Ohgata, the single Drosophila ortholog of human cereblon, regulates insulin signaling-dependent organismic growth

Wakabayashi, S., Sawamura, N., Voelzmann, A., Broemer, M., Asahi, T. & Hoch, M., 2016 Nov 25, In : Journal of Biological Chemistry. 291, 48, p. 25120-25132 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction

Sawamura, N., Wakabayashi, S., Matsumoto, K., Yamada, H. & Asahi, T., 2015 Sep 4, In : Biochemical and Biophysical Research Communications. 464, 4, p. 1054-1059 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2014

A label-free electrical assay of fibrous amyloid β based on semiconductor biosensing

Hideshima, S., Kobayashi, M., Wada, T., Kuroiwa, S., Nakanishi, T., Sawamura, N., Asahi, T. & Osaka, T., 2014 Apr 4, In : Chemical Communications. 50, 26, p. 3476-3479 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Arctic mutant Aβ40 aggregates on α7 nicotinic acetylcholine receptors and inhibits their functions

Ju, Y., Asahi, T. & Sawamura, N., 2014 Dec, In : Journal of neurochemistry. 131, 5, p. 667-674 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

Construction of photoenergetic mitochondria in cultured mammalian cells

Hara, K. Y., Wada, T., Kino, K., Asahi, T. & Sawamura, N., 2013 Apr 9, In : Scientific reports. 3, 1635.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2008

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

Sawamura, N., Ando, T., Maruyama, Y., Fujimuro, M., Mochizuki, H., Honjo, K., Shimoda, M., Toda, H., Sawamura-Yamamoto, T., Makuch, L. A., Hayashi, A., Ishizuka, K., Cascella, N. G., Kamiya, A., Ishida, N., Tomoda, T., Hai, T., Furukubo-Tokunaga, K. & Sawa, A., 2008 Dec, In : Molecular Psychiatry. 13, 12, p. 1138-1148 11 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

The fruitfly Drosophila melanogaster: A promising model to explore molecular psychiatry

Sawamura, N., Ishida, N., Tomoda, T., Hai, T., Furukubo-Tokunaga, K. & Sawa, A., 2008 Dec 1, In : Molecular Psychiatry. 13, 12, 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2006

Disrupted-in-Schizophrenia-1 (DISC1): A key susceptibility factor for major mental illnesses

Sawamura, N. & Sawa, A., 2006 Nov, Integrated Molecular Medicine for Neuronal and Neoplastic Disorders. Blackwell Publishing Inc., p. 126-133 8 p. (Annals of the New York Academy of Sciences; vol. 1086).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Citations (Scopus)

Primate disrupted-in-schizophrenia-1 (DISC1): High divergence of a gene for major mental illnesses in recent evolutionary history

Bord, L., Wheeler, J., Paek, M., Saleh, M., Lyons-Warren, A., Ross, C. A., Sawamura, N. & Sawa, A., 2006 Nov 1, In : Neuroscience Research. 56, 3, p. 286-293 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2005

A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse

Sawamura, N., Sawamura-Yamamoto, T., Ozeki, Y., Ross, C. A. & Sawa, A., 2005 Jan 25, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 4, p. 1187-1192 6 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

Kamiya, A., Kubo, K. I., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., Ross, C. A., Hatten, M. E., Nakajima, K. & Sawa, A., 2005 Dec 1, In : Nature Cell Biology. 7, 12, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

414 Citations (Scopus)

Disrupted-In-Schizophrenia-1 (DISC1): A promising lead in molecular analyzes of schizophrenia

Sawa, A., Sawamura, N. & Balkissoon, R., 2005 Sep, In : Clinical Neuroscience Research. 5, 1 SPEC. ISS., p. 23-30 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2004

Modulation of Amyloid Precursor Protein Cleavage by Cellular Sphingolipids

Sawamura, N., Ko, M., Yu, W., Zou, K., Hanada, K., Suzuki, T., Gong, J. S., Yanagisawa, K. & Michikawa, M., 2004 Mar 19, In : Journal of Biological Chemistry. 279, 12, p. 11984-11991 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2003

Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brain

Zou, K., Kim, D., Kakio, A., Byun, K., Gong, J. S., Kim, J., Kim, M., Sawamura, N., Nishimoto, S. I., Matsuzaki, K., Lee, B., Yanagisawa, K. & Michikawa, M., 2003 Nov 1, In : Journal of neurochemistry. 87, 3, p. 609-619 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells

Sawamura, N., Gong, J. S., Chang, T. Y., Yanagisawa, K. & Michikawa, M., 2003 Mar 1, In : Journal of neurochemistry. 84, 5, p. 1086-1096 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2002

Amyloid β-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade

Gong, J. S., Sawamura, N., Zou, K., Sakai, J., Yanagisawa, K. & Michikawa, M., 2002 Nov 2, In : Journal of Neuroscience Research. 70, 3, p. 438-446 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.

Gong, J. S., Kobayashi, M., Hayashi, H., Zou, K., Sawamura, N., Fujita, S. C., Yanagisawa, K. & Michikawa, M., 2002 Aug 16, In : The Journal of biological chemistry. 277, 33, p. 29919-29926 8 p.

Research output: Contribution to journalArticle

Open Access
154 Citations (Scopus)

Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons

Fan, Q. W., Yu, W., Gong, J. S., Zou, K., Sawamura, N., Senda, T., Yanagisawa, K. & Michikawa, M., 2002 Jun 20, In : Journal of neurochemistry. 80, 1, p. 178-190 13 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Erratum: Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons (Journal of Neurochemistry (80) (178-190))

Fan, Q. W., Yu, W., Gong, J. S., Zou, K., Sawamura, N., Senda, T., Yanagisawa, K. & Michikawa, M., 2002 Aug 5, In : Journal of neurochemistry. 80, 5, 1 p.

Research output: Contribution to journalComment/debate

2001

A novel action of Alzheimer's amyloid β-protein (Aβ): Oligomeric Aβ promotes lipid release

Michikawa, M., Gong, J. S., Fan, Q. W., Sawamura, N. & Yanagisawa, K., 2001 Sep 15, In : Journal of Neuroscience. 21, 18, p. 7226-7235 10 p.

Research output: Contribution to journalArticle

Open Access
131 Citations (Scopus)

Site-specific Phosphorylation of Tau Accompanied by Activation of Mitogen-activated Protein Kinase (MAPK) in Brains of Niemann-Pick Type C Mice

Sawamura, N., Gong, J. S., Garver, W. S., Heidenreich, R. A., Ninomiya, H., Ohno, K., Yanagisawa, K. & Michikawa, M., 2001 Mar 30, In : Journal of Biological Chemistry. 276, 13, p. 10314-10319 6 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
2000

Mutant presenilin 2 transgenic mice: A large increase in the levels of Aβ342 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin

Sawamura, N., Morishima-Kawashima, M., Waki, H., Kobayashi, K., Kuramochi, T., Frosch, M. P., Ding, K., Ito, M., Kim, T. W., Tanzi, R. E., Oyama, F., Tabira, T., Ando, S. & Ihara, Y., 2000 Sep 8, In : Journal of Biological Chemistry. 275, 36, p. 27901-27908 8 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
1998

Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid β-protein 42 in the brain

Oyama, F., Sawamura, N., Kobayashi, K., Morishima-Kawashima, M., Kuramochi, T., Ito, M., Tomita, T., Maruyama, K., Saido, T. C., Iwatsubo, T., Capell, A., Walter, J., Grünberg, J., Ueyama, Y., Haass, C. & Ihara, Y., 1998 Jul 1, In : Journal of neurochemistry. 71, 1, p. 313-322 10 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
1997

Amyloid β protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease

Tamaoka, A., Sawamura, N., Fukushima, T., Shoji, S., Matsubara, E., Shoji, M., Hirai, S., Furiya, Y., Endoh, R. & Mori, H., 1997 May 1, In : Journal of the Neurological Sciences. 148, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Characterization of amyloid β protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay

Sawamura, N., Tamaoka, A., Shoji, S. N. I., Koo, E. H., Walker, L. C. & Mori, H., 1997 Aug 1, In : Brain Research. 764, 1-2, p. 225-229 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Deposition of amyloid β protein (Aβ) subtypes [Aβ40 and Aβ42(43)] in canine senile plaques and cerebral amyoloid angiopathy

Nakamura, S., Tamaoka, A., Sawamura, N., Kiatipattanasakul, W., Nakayama, H., Shoji, S., Yoshikawa, Y. & Doi, K., 1997 Oct 1, In : Acta Neuropathologica. 94, 4, p. 323-328 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1996

Amyloid β protein in plasma from patients with sporadic Alzheimer' s disease

Tamaoka, A., Fukushima, T., Sawamura, N., Ishikawa, K., Oguni, E., Komatsuzaki, Y. & Shoji, S., 1996 Sep 15, In : Journal of the Neurological Sciences. 141, 1-2, p. 65-68 4 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
1995

Amyloid β protein 1-42/43 (Aβ 1-42/43) in cerebellar diffuse plaques: enzyme-linked immunosorbent assay and immunocytochemical study

Tamaoka, A., Sawamura, N., Odaka, A., Suzuki, N., Mizusawa, H., Shoji, S. & Mori, H., 1995 May 8, In : Brain Research. 679, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Carboxyl end-specific monoclonal antibodies to amyloid β protein (Aβ) subtypes (Aβ40 and Aβ42(43)) differentiate Aβ in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeys

Nakamura, S., Tamaoka, A., Sawamura, N., Shoji, S., Nakayama, H., Ono, F., Sakakibara, I., Yoshikawa, Y., Mori, H., Goto, N. & Doi, K., 1995 Dec 8, In : Neuroscience Letters. 201, 2, p. 151-154 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
1994

Biochemical evidence for the long-tail form (Aβ1-42/43) of amyloid β protein as a seed molecule in cerebral deposits of alzheimer′s disease

Tamaoka, A., Kondo, T., Odaka, A., Sahara, N., Sawamura, N., Ozawa, K., Suzuki, N., Shoji, S. & Mori, H., 1994 Nov 30, In : Biochemical and Biophysical Research Communications. 205, 1, p. 834-842 9 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)