Seijiro Hosokawa &ndash; Research Output

2006

23 Citations (Scopus)

Total syntheses of bioactive natural products from carbohydrates

Tatsuta, K. & Hosokawa, S., 2006 Jul, In : Science and Technology of Advanced Materials. 7, 5, p. 397-410 14 p.

Research output: Contribution to journal › Article

Carbohydrates

Biological Products

Molecules

Tetracycline

BE 54238B

20 Citations (Scopus)

Total syntheses of polyketide-derived bioactive natural products

Tatsuta, K. & Hosokawa, S., 2006, In : Chemical Record. 6, 4, p. 217-233 17 p.

Research output: Contribution to journal › Article

Polyketides

Biological Products

Polycyclic Compounds

Lactones

Tetracycline

33 Citations (Scopus)

Total synthesis of an antitubercular lactone antibiotic, (+)-tubelactomicin A

Hosokawa, S., Seki, M., Fukuda, H. & Tatsuta, K., 2006 Apr 3, In : Tetrahedron Letters. 47, 14, p. 2439-2442 4 p.

Research output: Contribution to journal › Article

Antitubercular Antibiotics

Cycloaddition Reaction

Lactones

Anti-Bacterial Agents

ribonolactone

2005

10 Citations (Scopus)

Stereoselective 1,5-rearrangement of vinylketene-N,O-acetals: Novel vinylogous Ferrier reaction

Inui, M., Hosokawa, S., Nakazaki, A. & Kobayashi, S., 2005 May 2, In : Tetrahedron Letters. 46, 18, p. 3245-3248 4 p.

Research output: Contribution to journal › Article

Lewis Acids

Acetals

Methylene Chloride

Ions

Experiments

49 Citations (Scopus)

The first total synthesis of trichostatin D

Hosokawa, S., Ogura, T., Togashi, H. & Tatsuta, K., 2005 Jan 10, In : Tetrahedron Letters. 46, 2, p. 333-337 5 p.

Research output: Contribution to journal › Article

Glycosylation

Acetals

trichostatin D

65 Citations (Scopus)

Total synthesis of selected bioactive natural products: Illustration of strategy and design

Tatsuta, K. & Hosokawa, S., 2005 Dec, In : Chemical Reviews. 105, 12, p. 4707-4729 23 p.

Research output: Contribution to journal › Article

Biological Products

Glycosylation

Nitrogen

2004

11 Citations (Scopus)

Acetoxyl group directed cyclization promoted by SmI₂: Directing group determined stereocomplementarity

Kan, T., Hosokawa, S., Nara, S., Tamiya, H., Shirahama, H. & Matsuda, F., 2004 Dec 10, In : Journal of Organic Chemistry. 69, 25, p. 8956-8958 3 p.

Research output: Contribution to journal › Article

Cyclization

Ketones

Alkenes

Aldehydes

Acetates

23 Citations (Scopus)

Highly efficient total synthesis of (+)-citreoviral

Murata, Y., Kamino, T., Aoki, T., Hosokawa, S. & Kobayashi, S., 2004 Jun 14, In : Angewandte Chemie - International Edition. 43, 24, p. 3175-3177 3 p.

Research output: Contribution to journal › Article

Imides

Alcohols

citreoviral

3-hydroxybutanal

137 Citations (Scopus)

Remote asymmetric induction with vinylketene silyl N,O-acetal

Shirokawa, S. I., Kamiyama, M., Nakamura, T., Okada, M., Nakazaki, A., Hosokawa, S. & Kobayashi, S., 2004 Oct 27, In : Journal of the American Chemical Society. 126, 42, p. 13604-13605 2 p.

Research output: Contribution to journal › Article

Stereoselectivity

Acetals

Polyketides

3-hydroxybutanal

titanium tetrachloride

2003

15 Citations (Scopus)

1,3-Rearrangement of ketene-N,O-acetals

Suzuki, T., Inui, M., Hosokawa, S. & Kobayashi, S., 2003 Apr 28, In : Tetrahedron Letters. 44, 18, p. 3713-3716 4 p.

Research output: Contribution to journal › Article

Lewis Acids

Acetals

Stereochemistry

Alkylation

Carbon

31 Citations (Scopus)

Stereoselective construction of a quaternary carbon substituted with multifunctional groups: Application to the concise synthesis of (+)-ethosuximide

Abe, T., Suzuki, T., Sekiguchi, K., Hosokawa, S. & Kobayashi, S., 2003 Dec 22, In : Tetrahedron Letters. 44, 52, p. 9303-9305 3 p.

Research output: Contribution to journal › Article

Ethosuximide

Imides

Stereoselectivity

Carbonyl compounds

Iodides

2002

29 Citations (Scopus)

Stereocontrolled preparation of 1,2-diol with quaternary chiral center

Murata, Y., Kamino, T., Hosokawa, S. & Kobayashi, S., 2002 Nov 4, In : Tetrahedron Letters. 43, 45, p. 8121-8123 3 p.

Research output: Contribution to journal › Article

Lactates

Bearings (structural)

Stereochemistry

Titanium

Anions

2001

24 Citations (Scopus)

Stereochemical control of tertiary alcohol: Aldol condensation of lactate derivatives

Kamino, T., Murata, Y., Kawai, N., Hosokawa, S. & Kobayashi, S., 2001 Jul 30, In : Tetrahedron Letters. 42, 31, p. 5249-5252 4 p.

Research output: Contribution to journal › Article

Condensation

Lactic Acid

Alcohols

Derivatives

Stereochemistry

16 Citations (Scopus)

Total synthesis of madindoline A

Hosokawa, S. & Kobayashi, S., 2001 Nov, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 59, 11, p. 1103-1108 6 p.

Research output: Contribution to journal › Article

Bearings (structural)

Amination

Alkylation

Aldehydes

Amines

2000

57 Citations (Scopus)

Novel stereoselective construction of a quaternary carbon: Application to synthesis of the cyclopentenedione moiety of madindolines

Hosokawa, S., Sekiguchi, K., Enemoto, M. & Kobayashi, S., 2000 Aug 12, In : Tetrahedron Letters. 41, 33, p. 6429-6433 5 p.

Research output: Contribution to journal › Article

Alkylation

Condensation

Carbon

29 Citations (Scopus)

Total synthesis of madindoline A

Hosokawa, S., Sekiguchi, K., Hayase, K., Hirukawa, Y. & Kobayashi, S., 2000 Aug 12, In : Tetrahedron Letters. 41, 33, p. 6435-6439 5 p.

Research output: Contribution to journal › Article

Skeleton

Aldehydes

Acids

Condensation

Derivatives

1999

87 Citations (Scopus)

Mirror image synthesis left ends of ciguatoxin and gambiertoxin 4b

Hosokawa, S. & Isobe, M., 1999 Jan 8, In : Journal of Organic Chemistry. 64, 1, p. 37-48 12 p.

Research output: Contribution to journal › Article

Ciguatoxins

Mirrors

Pentoses

Acetylene

Stereochemistry

54 Citations (Scopus)

Total synthesis and chemical biology of the sarcodictyins

Nicolaou, K. C., Pfefferkorn, J., Xu, J., Winssinger, N., Ohshima, T., Kim, S., Hosokawa, S., Vourloumis, D., Van Delft, F. & Li, T., 1999 Sep, In : Chemical and Pharmaceutical Bulletin. 47, 9, p. 1199-1213 15 p.

Research output: Contribution to journal › Article

Diterpenes

Structure-Activity Relationship

Tubulin

Cytotoxicity

Paclitaxel

Total synthesis of sarcodictyins A and B: Solid- and solution-phase synthesis and biological evaluation of combinatorial sarcodictyin libraries

Nicolaou, K. C., Winssinger, N., Vourloumis, D., Ohshima, T., Kim, S., Pfefferkorn, J., Xu, J. Y., Li, T. & Hosokawa, S., 1999 Dec, In : Chemtracts. 12, 14, p. 1006-1012 7 p.

Research output: Contribution to journal › Article

Solid-Phase Synthesis Techniques

Libraries

1998

67 Citations (Scopus)

1,4-anti induction in C-glycosylation of pentose glycals

Hosokawa, S., Kirschbaum, B. & Isobe, M., 1998 Apr 2, In : Tetrahedron Letters. 39, 14, p. 1917-1920 4 p.

Research output: Contribution to journal › Article

Glycosylation

Pentoses

Stereoselectivity

Regioselectivity

Ions

88 Citations (Scopus)

Reductive decomplexation of biscobalthexacarbonyl acetylenes into olefins

Hosokawa, S. & Isobe, M., 1998 Apr 23, In : Tetrahedron Letters. 39, 17, p. 2609-2612 4 p.

Research output: Contribution to journal › Article

Acetylene

Alkynes

Alkenes

Derivatives

tributyltin

123 Citations (Scopus)

Stereocontrolled synthesis and reactivity of sugar acetylenes

Isobe, M., Nishizawa, R., Hosokawa, S. & Nishikawa, T., 1998 Dec 21, In : Chemical Communications. 24, p. 2665-2676 12 p.

Research output: Contribution to journal › Article

Alkynes

Acetylene

Sugars

Cobalt

Derivatives

63 Citations (Scopus)

Synthesis and biological activity of sarcodictyins

Nicolaou, K. C., Kim, S., Pfefferkorn, J., Xu, J., Ohshima, T., Hosokawa, S., Vourloumis, D. & Li, T., 1998 Jun 5, In : Angewandte Chemie - International Edition. 37, 10, p. 1418-1421 4 p.

Research output: Contribution to journal › Article

Bioactivity

Antineoplastic Agents

100 Citations (Scopus)

Total synthesis of eleutherobin and eleuthosides A and B

Nicolaou, K. C., Ohshima, T., Hosokawa, S., Van Delft, F. L., Vourloumis, D., Xu, J. Y., Pfefferkorn, J. & Kim, S., 1998 Sep 2, In : Journal of the American Chemical Society. 120, 34, p. 8674-8680 7 p.

Research output: Contribution to journal › Article

Glycosides

Esterification

Hydrogenation

Screening

Molecules

98 Citations (Scopus)

Total synthesis of sarcodictyins A and B

Nicolaou, K. C., Xu, J. Y., Kim, S., Pfefferkorn, J., Ohshima, T., Vourloumis, D. & Hosokawa, S., 1998 Sep 2, In : Journal of the American Chemical Society. 120, 34, p. 8661-8673 13 p.

Research output: Contribution to journal › Article

Esterification

Aldehydes

Anhydrides

Tubulin

Biological Products

1997

C-Glycosidation of silylpropargyl alcohols into glucals

Saeeng, R., Hosokawa, S. & Isobe, M., 1997 Jan 1, In : Nippon Nogeikagaku Kaishi. 71, p. 110-119 10 p.

Research output: Contribution to journal › Article

Calcium Gluconate

Alcohols

2 Citations (Scopus)

Enzyme inhibitors, synthesis and approach to mechanism

Isobe, M., Tsuboi, K., Hosokawa, S., Bamba, M., Kira, K., Shibuya, S., Ohtani, I. I., Nishikawa, T. & Ichikawa, Y., 1997 Mar, In : Pure and Applied Chemistry. 69, 3, p. 401-406 6 p.

Research output: Contribution to journal › Article

Ciguatoxins

Phosphoprotein Phosphatases

Tetrodotoxin

Enzyme Inhibitors

Enzymes

105 Citations (Scopus)

Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of sarcodictyin A

Nicolau, K. C., Xu, J. Y., Kim, S., Ohshima, T., Hosokawa, S. & Pfefferkorn, J., 1997, In : Journal of the American Chemical Society. 119, 46, p. 11353-11354 2 p.

Research output: Contribution to journal › Article

sarcodictyin A

eleutherobin

112 Citations (Scopus)

Total synthesis of eleutherobin

Nicolaou, K. C., Van Delft, F., Ohshima, T., Vourloumis, D., Xu, J., Hosokawa, S., Pfefferkorn, J., Kim, S. & Li, T., 1997, In : Angewandte Chemie - International Edition in English. 36, 22, p. 2520-2524 5 p.

Research output: Contribution to journal › Article

Biological Products

Antineoplastic Agents

eleutherobin

1996

57 Citations (Scopus)

Partial Synthesis of Ciguatoxin, an A/B/C Fragment

Hosokawa, S. & Isobe, M., 1996, In : Synlett. 1996, 4, p. 351-352 2 p.

Research output: Contribution to journal › Article

Ciguatoxins

Acetylene

Cyclization

Cations

Derivatives

64 Citations (Scopus)

syn-trans fused bicyclic ether formation via acetylene-biscobalthexacarbonyl complex

Isobe, M., Hosokawa, S. & Kira, K., 1996, In : Chemistry Letters. 6, p. 473-474 2 p.

Research output: Contribution to journal › Article

Ciguatoxins

Marine Toxins

Acetylene

Ethers

Cyclization

1995

64 Citations (Scopus)

Synthesis of two Diastereoisomers of A/B Fragment of Ciguatoxin

Hosokawa, S. & Isobe, M., 1995 Nov 1, In : Synlett. 1995, 11, p. 1179-1180 2 p.

Research output: Contribution to journal › Article

Ciguatoxins

Pentoses

Acetylene

Hexoses

Cyclization

1994

143 Citations (Scopus)

One pot synthesis of haloacetylenes from trimethylsilylacetylenes

Nishikawa, T., Shibuya, S., Hosokawa, S. & Isobe, M., 1994 Jul 1, In : Synlett. 1994, 7, p. 485-486 2 p.

Research output: Contribution to journal › Article

Functional groups

Substrates

esperamicin A1

7 Citations (Scopus)

Synthetic Studies on Grayanotoxins. Stereocontrolled Construction of CD-Ring of Grayanotoxins

Kan, T., Oikawa, M., Hosokawa, S., Yanagiya, M., Matsuda, F. & Shirahama, H., 1994 Oct 1, In : Synlett. 1994, 10, p. 805-808 4 p.

Research output: Contribution to journal › Article

Poisons

8 Citations (Scopus)

Synthetic Studies on Grayanotoxins Diastereofacially Selective Diels-Alder Reaction of 4-Benzyloxy-2-pentenoate

Kan, T., Oikawa, M., Hosokawa, S., Yanagiya, M., Matsuda, F. & Shirahama, H., 1994 Oct 1, In : Synlett. 1994, 10, p. 801-804 4 p.

Research output: Contribution to journal › Article

Poisons

Mirrors

1,3-butadiene

83 Citations (Scopus)

Total synthesis of (-)-grayanotoxin III

Kan, T., Hosokawa, S., Nara, S., Oikawa, M., Ito, S., Matsuda, F. & Shirahama, H., 1994, In : Journal of Organic Chemistry. 59, 19, p. 5532-5534 3 p.

Research output: Contribution to journal › Article

Diterpenes

Cyclization

grayanotoxin III