• 2582 Citations
  • 28 h-Index
19942019
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Research Output 1994 2019

  • 2582 Citations
  • 28 h-Index
  • 81 Article
  • 2 Review article
  • 1 Chapter
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Article
2019
1 Citation (Scopus)
Imides
Protonation
Lactones
Protons
Betula

Bioinspired Synthesis of the Central Core of Halichonadin H: The Passerini Reaction in a Hypothetical Biosynthesis of Marine Natural Products

Ichikawa, Y., Yamasaki, T., Nakanishi, K., Udagawa, Y., Hosokawa, S. & Masuda, T., 2019 Jan 1, In : Synthesis (Germany). 51, 11, p. 2305-2310 6 p.

Research output: Contribution to journalArticle

Terpenes
Biosynthesis
Biological Products
Cyanides
Formaldehyde

Synthesis of C3-C21 Segment of Aflastatin A Using Remote Asymmetric Induction Reactions

Murakoshi, S. & Hosokawa, S., 2019 Jan 1, (Accepted/In press) In : Organic Letters.

Research output: Contribution to journalArticle

Acetals
Alkylation
induction
synthesis
aflastatin A

Synthesis of the C1-C17 Segment of Bafilomycin N

Sato, H. & Hosokawa, S., 2019 Jan 1, In : Synlett. 30, 5, p. 577-580 4 p.

Research output: Contribution to journalArticle

Acetals
3-hydroxybutanal
semipinacol
2018
6 Citations (Scopus)
Acetals
Polyketides
Biological Products
Functional groups
Imides
3 Citations (Scopus)

Total Syntheses of Stoloniferol B and Penicitol A, and Structural Revision of Fusaraisochromanone

Ohashi, T. & Hosokawa, S., 2018 May 18, In : Organic Letters. 20, 10, p. 3021-3024 4 p.

Research output: Contribution to journalArticle

Citrinin
Enantiomers
Esterification
enantiomers
Cyclization

Total Synthesis and Structural Determination of XR774, a Tyrosine Kinase Inhibitor

Tatsuta, K., Sekine, D., Hayama, S., Kataoka, Y., Hayashi, S. & Hosokawa, S., 2018 Jul 6, In : Journal of Organic Chemistry. 83, 13, p. 7010-7018 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tetralones
Nickel
XR774
benzo(j)fluoranthene
2017
7 Citations (Scopus)

Remote Asymmetric Bromination Reaction with Vinylketene Silyl N,O-Acetal and Its Application to Total Synthesis of Pellasoren A

Sekiya, S., Okumura, M., Kubota, K., Nakamura, T., Sekine, D. & Hosokawa, S., 2017 May 5, In : Organic Letters. 19, 9, p. 2394-2397 4 p.

Research output: Contribution to journalArticle

Imides
bromination
acetals
Acetals
Halogenation
12 Citations (Scopus)

Remote asymmetric induction using acetate-type vinylketene silyl N,O-acetals

Sagawa, N., Sato, H. & Hosokawa, S., 2017 Jan 1, In : Organic Letters. 19, 1, p. 198-201 4 p.

Research output: Contribution to journalArticle

acetals
Acetals
adducts
acetates
induction
7 Citations (Scopus)

Stereoselective Synthesis of Tabtoxinine-β-lactam by Using the Vinylogous Mukaiyama Aldol Reaction with Acetate-Type Vinylketene Silyl N,O-Acetal and α-Keto-β-lactam

Ejima, H., Wakita, F., Imamura, R., Kato, T. & Hosokawa, S., 2017 May 19, In : Organic Letters. 19, 10, p. 2530-2532 3 p.

Research output: Contribution to journalArticle

glutamine
Lactams
acetals
hydrogenolysis
Acetals
9 Citations (Scopus)

Syn selective vinylogous mukaiyama aldol reaction using Z,EVinylketene N,O-acetal with acetals

Sagawa, N., Moriya, H. & Hosokawa, S., 2017 Jan 1, In : Organic Letters. 19, 1, p. 250-253 4 p.

Research output: Contribution to journalArticle

Imides
Polyketides
Stereoselectivity
acetals
Acetals
2016
10 Citations (Scopus)

Stereoselective Alkylation of the Vinylketene Silyl N,O-Acetal and Its Application to the Synthesis of Mycocerosic Acid

Nakamura, T., Kubota, K., Ieki, T. & Hosokawa, S., 2016 Jan 4, In : Organic Letters. 18, 1, p. 132-135 4 p.

Research output: Contribution to journalArticle

acetals
Acetals
alkylation
Alkylation
Iodides
2 Citations (Scopus)

Synthesis and antileishmanial activity of the core structure of cristaxenicin A

Fumiyama, H., Sadayuki, T., Osada, Y., Goto, Y., Nakao, Y. & Hosokawa, S., 2016 Sep 1, In : Bioorganic and Medicinal Chemistry Letters. 26, 17, p. 4355-4357 3 p.

Research output: Contribution to journalArticle

Aldehydes
Cycloaddition
Cycloaddition Reaction
Ketones
Inhibitory Concentration 50

Synthesis of 24,24-difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 derivatives and evaluation of their vitamin D receptor-binding affinity

Biswas, T., Akagi, Y., Usuda, K., Yasui, K., Shimizu, I., Okamoto, M., Uesugi, M., Hosokawa, S. & Nagasawa, K., 2016, In : Biological and Pharmaceutical Bulletin. 39, 8, p. 1387-1391 5 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Cholecalciferol
Inhibitory Concentration 50
1,25-dihydroxy-19-norvitamin D3

Synthesis of diastereomers of 1,3-cis-25-dihydroxy-19-norvitamin D3

Usuda, K., Biswas, T., Yamaguchi, T., Akagi, Y., Yasui, K., Uesugi, M., Shimizu, I., Hosokawa, S. & Nagasawa, K., 2016, In : Chemical and Pharmaceutical Bulletin. 64, 8, p. 1190-1195 6 p.

Research output: Contribution to journalArticle

Quinic Acid
Benzoates
Nuclear magnetic resonance
Circular Dichroism
Experiments
4 Citations (Scopus)

Total synthesis of PDIM A

Nakamura, T., Nakagome, H., Sano, S., Sadayuki, T. & Hosokawa, S., 2016, In : Chemistry Letters. 45, 5, p. 550-551 2 p.

Research output: Contribution to journalArticle

Arabinose
Epoxy Compounds
Alkylation
phthiocerol dimycocerosate
2015
6 Citations (Scopus)

Isolation, ECD assisted structural analyses, biosynthetic discussions, and biological activities of epi-cochlioquinones D and its derivatives

Arayama, M., Nehira, T., Maeda, H., Tanaka, K., Miyagawa, H., Ueno, T., Hosokawa, S. & Hashimoto, M., 2015, In : Tetrahedron. 71, 29, p. 4788-4794 7 p.

Research output: Contribution to journalArticle

Helminthosporium
Ascomycota
Chirality
Biosynthetic Pathways
Cytotoxicity
3 Citations (Scopus)

Stereoselective Synthesis of the C27-C48 Moiety of Aflastatin A by a Carbohydrate Strategy Using a Tin(II)-Mediated Aldol Reaction

Murakoshi, S. & Hosokawa, S., 2015 Oct 22, In : Synlett. 26, 17, p. 2437-2441 5 p., st-2015-u0570-l.

Research output: Contribution to journalArticle

Tin
Carbohydrates
Mannosides
Stereochemistry
Aldehydes
9 Citations (Scopus)

Synthetic studies on aculeximycin: Synthesis of C24-C40 segment by kobayashi aldolization and epoxide rearrangements

Kato, T., Sato, T., Kashiwagi, Y. & Hosokawa, S., 2015 May 1, In : Organic Letters. 17, 9, p. 2274-2277 4 p.

Research output: Contribution to journalArticle

epoxy compounds
Epoxy Compounds
Epoxidation
synthesis
epoxidation
2014
13 Citations (Scopus)

Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages

Oshio, T., Kawashima, R., Kawamura, Y. I., Hagiwara, T., Mizutani, N., Okada, T., Otsubo, T., Inagaki-Ohara, K., Matsukawa, A., Haga, T., Kakuta, S., Iwakura, Y., Hosokawa, S. & Dohi, T., 2014 Apr 8, In : PLoS One. 9, 4, e94445.

Research output: Contribution to journalArticle

CCR Receptors
Macrophages
Peritoneal Macrophages
lipopolysaccharides
Lipopolysaccharides
2 Citations (Scopus)

Concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ)

Sekine, D., Okeda, S. & Hosokawa, S., 2014, In : Chemistry Letters. 43, 12, p. 1932-1934 3 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cyclization
Ligands
6-formylindolo(3,2-b)carbazole
3-formylindole
14 Citations (Scopus)

Stereoselective acylation of the E, e -vinylketene silyl N, O -acetal and its application to the synthesis of khafrefungin

Takahashi, Y., Otsuka, M., Harachi, M., Mukaeda, Y. & Hosokawa, S., 2014 Aug 15, In : Organic Letters. 16, 16, p. 4106-4109 4 p.

Research output: Contribution to journalArticle

acylation
acetals
Acylation
Acetals
Anhydrides
6 Citations (Scopus)

Total synthesis of hibarimicinone, a v-Src tyrosine kinase inhibitor possessing the pseudo-dimer structure of tetracycline

Tatsuta, K. & Hosokawa, S., 2014 Feb, In : Chemical Record. 14, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

src-Family Kinases
Tetracycline
Dimers
Oxidation
Cyclization
2013
14 Citations (Scopus)

Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Nakamura, T., Harachi, M., Kano, T., Mukaeda, Y. & Hosokawa, S., 2013 Jun 21, In : Organic Letters. 15, 12, p. 3170-3173 4 p.

Research output: Contribution to journalArticle

Propionates
Antimalarials
synthesis
Isomers
isomers
22 Citations (Scopus)

Syn-selective kobayashi aldol reaction using acetals

Tsukada, H., Mukaeda, Y. & Hosokawa, S., 2013 Feb 1, In : Organic Letters. 15, 3, p. 678-681 4 p.

Research output: Contribution to journalArticle

acetals
Acetals
Polyketides
Stereoselectivity
Lewis Acids
2012
27 Citations (Scopus)

Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Mukaeda, Y., Kato, T. & Hosokawa, S., 2012 Oct 19, In : Organic Letters. 14, 20, p. 5298-5301 4 p.

Research output: Contribution to journalArticle

acetals
Acetals
products
Polyketides
musculoskeletal system
18 Citations (Scopus)

The first total synthesis of hibarimicinone, a potent v-Src tyrosine kinase inhibitor

Tatsuta, K., Fukuda, T., Ishimori, T., Yachi, R., Yoshida, S., Hashimoto, H. & Hosokawa, S., 2012 Jan 25, In : Tetrahedron Letters. 53, 4, p. 422-425 4 p.

Research output: Contribution to journalArticle

src-Family Kinases
Aromatization
Arabinose
Skeleton
Condensation
2011
13 Citations (Scopus)

The first total synthesis and structural determination of antibiotics K1115 B1s (alnumycins)

Tatsuta, K., Tokishita, S., Fukuda, T., Kano, T., Komiya, T. & Hosokawa, S., 2011 Mar 2, In : Tetrahedron Letters. 52, 9, p. 983-986 4 p.

Research output: Contribution to journalArticle

Stereoisomerism
Optical rotation
Anti-Bacterial Agents
Optical Rotation
Isomers
2010
28 Citations (Scopus)

The first total synthesis and structural determination of epi-cochlioquinone A

Hosokawa, S., Matsushita, K., Tokimatsu, S., Toriumi, T., Suzuki, Y. & Tatsuta, K., 2010 Oct 20, In : Tetrahedron Letters. 51, 42, p. 5532-5536 5 p.

Research output: Contribution to journalArticle

Oxidation
Cycloaddition
Cyclization
Cycloaddition Reaction
Cyanides
20 Citations (Scopus)

The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic

Tatsuta, K., Tanaka, H., Tsukagoshi, H., Kashima, T. & Hosokawa, S., 2010 Oct 20, In : Tetrahedron Letters. 51, 42, p. 5546-5549 4 p.

Research output: Contribution to journalArticle

Cyclization
Glycosylation
Esters
Alcohols
Anti-Bacterial Agents
2009
15 Citations (Scopus)
Acetals
Biological Products
Lactic Acid
Carbon
Alcohols
16 Citations (Scopus)

The first total synthesis and structural determination of benzopyrenomycin

Hosokawa, S., Mukaeda, Y., Kawahara, R. & Tatsuta, K., 2009 Dec 2, In : Tetrahedron Letters. 50, 48, p. 6701-6704 4 p.

Research output: Contribution to journalArticle

Cyclization
Skeleton
benzopyrenomycin
benzanthrone
3-hydroxybutanal
5 Citations (Scopus)

The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities

Tatsuta, K., Yoshihara, S., Hattori, N., Yoshida, S. & Hosokawa, S., 2009 Aug, In : Journal of Antibiotics. 62, 8, p. 469-470 2 p.

Research output: Contribution to journalArticle

Antineoplastic Antibiotics
Xanthines
Ultraviolet Spectrophotometry
Molecular Conformation
X Ray Crystallography
2008
52 Citations (Scopus)
Acetals
Biological Products
Functional groups
3-hydroxybutanal
8 Citations (Scopus)

The first total synthesis and structural determination of TMC-264

Tatsuta, K., Furuyama, A., Yano, T., Suzuki, Y., Ogura, T. & Hosokawa, S., 2008 Jun 16, In : Tetrahedron Letters. 49, 25, p. 4036-4039 4 p.

Research output: Contribution to journalArticle

Pyrans
Lewis Acids
Halogenation
Cyclization
Nickel
22 Citations (Scopus)

Total synthesis of an anti-Helicobacter pylori agent, actinopyrone A

Hosokawa, S., Yokota, K., Imamura, K., Suzuki, Y., Kawarasaki, M. & Tatsuta, K., 2008 Sep 1, In : Chemistry - An Asian Journal. 3, 8-9, p. 1415-1421 7 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Organophosphonates
Sulfones
Stereochemistry
Ether
2007
16 Citations (Scopus)

The first total synthesis and structural determination of (+)-BE-52440A

Tatsuta, K., Suzuki, Y., Toriumi, T., Furuya, Y. & Hosokawa, S., 2007 Nov 5, In : Tetrahedron Letters. 48, 45, p. 8018-8021 4 p.

Research output: Contribution to journalArticle

Regioselectivity
Dimerization
Epoxy Compounds
Dimers
BE 52440 A
19 Citations (Scopus)

The first total synthesis and structural determination of TMC-66

Hosokawa, S., Fumiyama, H., Fukuda, H., Fukuda, T., Seki, M. & Tatsuta, K., 2007 Oct 8, In : Tetrahedron Letters. 48, 41, p. 7305-7308 4 p.

Research output: Contribution to journalArticle

Oxidative Coupling
Phenols
Copper
Electrons
TMC 66
15 Citations (Scopus)

The first total synthesis and structural determination of YCM1008A

Tatsuta, K., Yamaguchi, T., Tsuda, Y., Yamaguchi, Y., Hattori, N., Nagai, H. & Hosokawa, S., 2007 Jun 11, In : Tetrahedron Letters. 48, 24, p. 4187-4190 4 p.

Research output: Contribution to journalArticle

Pyridones
YCM 1008A
21 Citations (Scopus)

The first total synthesis of vinaxanthone, a fungus metabolite possessing multiple bioactivities

Tatsuta, K., Kasai, S., Amano, Y., Yamaguchi, T., Seki, M. & Hosokawa, S., 2007 Jan 5, In : Chemistry Letters. 36, 1, p. 10-11 2 p.

Research output: Contribution to journalArticle

Cycloaddition
Metabolites
Bioactivity
Fungi
Molecules
48 Citations (Scopus)

Total synthesis of khafrefungin using highly stereoselective vinylogous Mukaiyama aldol reaction

Shirokawa, S. I., Shinoyama, M., Ooi, I., Hosokawa, S., Nakazaki, A. & Kobayashi, S., 2007 Mar 1, In : Organic Letters. 9, 5, p. 849-852 4 p.

Research output: Contribution to journalArticle

acetals
Acetals
synthesis
Ketones
Dehydration
24 Citations (Scopus)

YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., Iwamoto, S., Suzuki, M., Kakita, S., Rahayu, E. S., Hosokawa, S., Tatsuta, K. & Ichimura, M., 2007 Jul, In : Journal of Antibiotics. 60, 7, p. 455-458 4 p.

Research output: Contribution to journalArticle

Fusarium
Preclinical Drug Evaluations
Growth
Fermentation
Saccharomyces cerevisiae
2006
97 Citations (Scopus)

Enantioselective total synthesis of convolutamydines B and E

Nakamura, T., Shirokawa, S. I., Hosokawa, S., Nakazaki, A. & Kobayashi, S., 2006 Feb 16, In : Organic Letters. 8, 4, p. 677-679 3 p.

Research output: Contribution to journalArticle

Isatin
synthesis
aldehydes
Aldehydes
configurations
32 Citations (Scopus)

The first total synthesis and structural determination of actinopyrone A

Hosokawa, S., Yokota, K., Imamura, K., Suzuki, Y., Kawarasaki, M. & Tatsuta, K., 2006 Jul 24, In : Tetrahedron Letters. 47, 30, p. 5415-5418 4 p.

Research output: Contribution to journalArticle

Pyrones
Methylation
actinopyrone A
25 Citations (Scopus)

The first total synthesis and structural determination of lagunamycin

Hosokawa, S., Kuroda, S., Imamura, K. & Tatsuta, K., 2006 Aug 28, In : Tetrahedron Letters. 47, 35, p. 6183-6186 4 p.

Research output: Contribution to journalArticle

Condensation
Nuclear magnetic resonance
Oxidation
lagunamycin
23 Citations (Scopus)

Total syntheses of bioactive natural products from carbohydrates

Tatsuta, K. & Hosokawa, S., 2006 Jul, In : Science and Technology of Advanced Materials. 7, 5, p. 397-410 14 p.

Research output: Contribution to journalArticle

Carbohydrates
Biological Products
Molecules
Tetracycline
BE 54238B
20 Citations (Scopus)

Total syntheses of polyketide-derived bioactive natural products

Tatsuta, K. & Hosokawa, S., 2006, In : Chemical Record. 6, 4, p. 217-233 17 p.

Research output: Contribution to journalArticle

Polyketides
Biological Products
Polycyclic Compounds
Lactones
Tetracycline
33 Citations (Scopus)

Total synthesis of an antitubercular lactone antibiotic, (+)-tubelactomicin A

Hosokawa, S., Seki, M., Fukuda, H. & Tatsuta, K., 2006 Apr 3, In : Tetrahedron Letters. 47, 14, p. 2439-2442 4 p.

Research output: Contribution to journalArticle

Antitubercular Antibiotics
Cycloaddition Reaction
Lactones
Anti-Bacterial Agents
ribonolactone
2005
10 Citations (Scopus)

Stereoselective 1,5-rearrangement of vinylketene-N,O-acetals: Novel vinylogous Ferrier reaction

Inui, M., Hosokawa, S., Nakazaki, A. & Kobayashi, S., 2005 May 2, In : Tetrahedron Letters. 46, 18, p. 3245-3248 4 p.

Research output: Contribution to journalArticle

Lewis Acids
Acetals
Methylene Chloride
Ions
Experiments
49 Citations (Scopus)

The first total synthesis of trichostatin D

Hosokawa, S., Ogura, T., Togashi, H. & Tatsuta, K., 2005 Jan 10, In : Tetrahedron Letters. 46, 2, p. 333-337 5 p.

Research output: Contribution to journalArticle

Glycosylation
Acetals
trichostatin D