• 6719 Citations
  • 44 h-Index
1985 …2020

Research output per year

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Research Output

Article

Methemoglobin formation in hemoglobin vesicles and reduction by encapsukated thiols

Takeoka, S., Sakai, H., Kose, T., Mano, Y., Seino, Y., Nishide, H. & Tsuchida, E., 1997 Jul 1, In : Bioconjugate Chemistry. 8, 4, p. 539-544 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Micro-thermography in millimeter-scale animals by using orally-dosed fluorescent nanoparticle thermosensors

Arai, S., Ferdinandus, Takeoka, S., Ishiwata, SI., Sato, H. & Suzuki, M., 2015 Nov 21, In : Analyst. 140, 22, p. 7534-7539 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: Influence of O2 affinity

Sakai, H., Tsai, A. G., Rohlfs, R. J., Hara, H., Takeoka, S., Tsuchida, E. & Intaglietta, M., 1999 Feb 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 276, 2 45-2, p. H553-H562

Research output: Contribution to journalArticle

86 Citations (Scopus)

Modification of Hb-vesicles with oligosaccharide chains

Sakai, H., Takisada, M., Chung, J. E., Takeoka, S. & Tsuchida, E., 1994 Jan 1, In : Japanese Journal of Artificial Organs. 23, 3, p. 864-867 4 p.

Research output: Contribution to journalArticle

Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension

Sakai, H., Hara, H., Yuasa, M., Tsai, A. G., Takeoka, S., Tsuchida, E. & Intaglietta, M., 2000 Oct 4, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 3 48-3, p. H908-H915

Research output: Contribution to journalArticle

170 Citations (Scopus)

Morphological evolution within spin-cast ultrathin polymer blend films clarified by a freestanding method

Zhang, H. & Takeoka, S., 2012 May 22, In : Macromolecules. 45, 10, p. 4315-4321 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

Tsuji, T., Takeoka, S., Okamura, Y., Sudo, R., Ikeda, Y. & Tanishita, K., 2009 Dec 1, In : Journal of Biorheology. 23, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ)

Nabetani, T., Makino, A., Hullin-Matsuda, F., Hirakawa, T. A., Takeoka, S., Okino, N., Ito, M., Kobayashi, T. & Hirabayashi, Y., 2011 Jun, In : Journal of Lipid Research. 52, 6, p. 1294-1302 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue

Contaldo, C., Plock, J., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M., Banic, A. & Erni, D., 2005 Apr 1, In : Critical Care Medicine. 33, 4, p. 806-812 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
28 Citations (Scopus)

NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

Li, T., Zehner, M., He, J., Próchnicki, T., Horvath, G., Latz, E., Burgdorf, S. & Takeoka, S., 2019, In : International Journal of Nanomedicine. 14, p. 3503-3516 14 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers

Sakai, H., Sato, A., Sobolewski, P., Takeoka, S., Frangos, J. A., Kobayashi, K., Intaglietta, M. & Tsuchida, E., 2008 Oct 1, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1784, 10, p. 1441-1447 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Nonaqueous proton conduction in poly(thiophenylenesulfonic acid)/poly(oxyethylene) composite

Miyatake, K., Fukushima, K., Takeoka, S. & Tsuchida, E., 1999 Jan 1, In : Chemistry of Materials. 11, 5, p. 1171-1173 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue

Erni, D., Wettstein, R., Schramm, S., Contaldo, C., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M. & Banic, A., 2003 May 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 5 53-5, p. H1702-H1709

Research output: Contribution to journalArticle

24 Citations (Scopus)

Novel platelet substitutes: Disk-shaped biodegradable nanosheets and their enhanced effects on platelet aggregation

Okamura, Y., Fukui, Y., Kabata, K., Suzuki, H., Handa, M., Ikeda, Y. & Takeoka, S., 2009 Oct 21, In : Bioconjugate Chemistry. 20, 10, p. 1958-1965 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Novel technique of overlaying a poly-L-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

Fujino, K., Kinoshita, M., Saitoh, A., Yano, H., Nishikawa, K., Fujie, T., Iwaya, K., Kakihara, M., Takeoka, S., Saitoh, D. & Tanaka, Y., 2011 Oct, In : Surgical Endoscopy. 25, 10, p. 3428-3436 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous tensile strength in rat microneurosurgery

Otani, N., Kinoshita, M., Fujie, T., Saito, A., Takeoka, S., Saitoh, D., Hagisawa, K., Nawashiro, H. & Shima, K., 2013 Feb 1, In : Journal of Clinical Neuroscience. 20, 2, p. 301-305 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

O2 binding and dissociation and ligand exchange reaction of O2 with CO in polymer composite films of hemoglobin

Park, S. I., Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1997 Jun, In : Polymers for Advanced Technologies. 8, 6, p. 366-370 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

O2 release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: Comparison with RBCs and acellular Hbs

Sakai, H., Suzuki, Y., Kinoshita, M., Takeoka, S., Maeda, N. & Tsuchida, E., 2003 Dec, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 6 54-6, p. H2543-H2551

Research output: Contribution to journalArticle

34 Citations (Scopus)

On the injectability of free-standing magnetic nanofilms

Taccola, S., Pensabene, V., Fujie, T., Takeoka, S., Pugno, N. M. & Mattoli, V., 2017 Sep 1, In : Biomedical Microdevices. 19, 3, 51.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Optomechanical characterization of freestanding stretchable nanosheet based on polystyrene-polybutadiene-polystyrene copolymer

Kumagai, H., Sato, N., Takeoka, S., Sawada, K., Fujie, T. & Takahashi, K., 2017 Jan 1, In : Applied Physics Express. 10, 1, 011601.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oxidation of a PPy‐modified tantalum electrode

Park, YS. S., Yamamoto, K., Takeoka, S., Ohta, T. & Tsuchida, E., 1993, In : Polymers for Advanced Technologies. 4, 5, p. 329-334 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oxygen‐binding property of hemoglobin films

Chung, J., Takeoka, S., Nishide, H. & Tsuchida, E., 1994 Jul, In : Polymers for Advanced Technologies. 5, 7, p. 385-389 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oxygen infusions (hemoglobin-vesicles and albumin-hemes) based on nano-molecular sciences

Tsuchida, E., Sakai, H., Komatsu, T., Takeoka, S., Huang, Y., Sou, K., Nakagawa, A., Teramura, Y. & Kobayashi, K., 2005 Feb 1, In : Polymers for Advanced Technologies. 16, 2-3, p. 73-83 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oxygen releasing from cellular hemoglobin

Kawai, N., Ohkawa, H., Maejima, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 507-517 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Oxygen-transport and solution properties of polylipid/hb vesicles (arc)

Takeoka, S., Hasegawa, E., Nishide, H., Tsuchida, E. & Sekiguchi, S., 1992 Jan, In : Biomaterials, Artificial Cells and Immobilization Biotechnology. 20, 4 --Feb, p. 399-404 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution

Cabrales, P., Sakai, H., Tsai, A. G., Takeoka, S., Tsuchida, E. & Intaglietta, M., 2005 Apr 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 4 57-4, p. H1885-H1892

Research output: Contribution to journalArticle

45 Citations (Scopus)

Patchwork coating of fragmented ultra-thin films and their biomedical applications in burn therapy and antithrombotic coating

Okamura, Y., Nagase, Y. & Takeoka, S., 2015, In : Materials. 8, 11, p. 7604-7614 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25 μm)

Sakai, H., Sato, A., Okuda, N., Takeoka, S., Maeda, N. & Tsuchida, E., 2009 Aug 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H583-H589

Research output: Contribution to journalArticle

16 Citations (Scopus)

Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Shi, X., Fujie, T., Saito, A., Takeoka, S., Hou, Y., Shu, Y., Chen, M., Wu, H. & Khademhosseini, A., 2014 May 28, In : Advanced Materials. 26, 20, p. 3290-3296 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia

Hashimoto, M., Taguchi, K., Ogaki, S., Watanabe, H., Kinoshita, M., Nishikawa, K., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2015 Nov 1, In : Journal of Pharmaceutical Sciences. 104, 11, p. 3968-3976 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Taguchi, K., Ujihira, H., Watanabe, H., Fujiyama, A., Doi, M., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 Oct, In : Journal of Pharmaceutical Sciences. 102, 10, p. 3852-3859 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen g-chain dodecapeptide as a synthetic platelet substitutes

Taguchi, K., Ujihira, H., Ogaki, S., Watanabe, H., Fujiyama, A., Doi, M., Okamura, Y., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 Aug, In : Drug Metabolism and Disposition. 41, 8, p. 1584-1591 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Phase Separation of Polymerized Mixed Liposomes: Analysis of Release Behavior of Entrapped Molecules with Skeletonization

Takeoka, S., Sakai, H., Ohno, H. & Tsuchida, E., 1991 Nov 1, In : Macromolecules. 24, 6, p. 1279-1283 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation

Inaba, T., Kishimoto, T., Murate, M., Tajima, T., Sakai, S., Abe, M., Makino, A., Tomishige, N., Ishitsuka, R., Ikeda, Y., Takeoka, S. & Kobayashi, T., 2016 Jul 12, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 28, p. 7834-7839 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Photoexcitation and Electron Transfer Reactions of Zinc Lipidporphyrins in DMSO

Ohgushi, T., Li, Z. C., Li, F. M., Komatsu, T., Takeoka, S. & Tsuchida, E., 1999 Jan, In : Journal of Porphyrins and Phthalocyanines. 3, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Photoreduction of methemoglobin by irradiation in the near-ultraviolet region

Sakai, H., Onuma, H., Umeyama, M., Takeoka, S. & Tsuchida, E., 2000 Nov 28, In : Biochemistry. 39, 47, p. 14595-14602 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Physical properties and packing states of molecular assemblies of synthetic glycolipids in aqueous dispersions

Takeoka, S., Sou, K., Boettcher, C., Fuhrhop, J. H. & Tsuchida, E., 1998 Aug 7, In : Journal of the Chemical Society - Faraday Transactions. 94, 15, p. 2151-2158 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Physical properties of hemoglobin vesicles as red cell substitutes

Sakai, H., Hamada, K., Takeoka, S., Nishide, H. & Tsuchida, E., 1996 Jan 1, In : Biotechnology Progress. 12, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier

Komatsu, T., Oguro, Y., Teramura, Y., Takeoka, S., Okai, J., Anraku, M., Otagiri, M. & Tsuchida, E., 2004 Nov 18, In : Biochimica et Biophysica Acta - General Subjects. 1675, 1-3, p. 21-31 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Sakai, H., Masada, Y., Horinouchi, H., Ikeda, E., Sou, K., Takeoka, S., Suematsu, M., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Dec 1, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 874-884 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Physiologic responses to exchange transfusion with hemoglobin vesicles as an artificial oxygen carrier in anesthetized rats: Changes in mean arterial pressure and renal cortical tissue oxygen tension

Izumi, Y., Sakai, H., Hamada, K., Takeoka, S., Yamahata, T., Kato, R., Nishide, H., Tsuchida, E. & Kobayashi, K., 1996 Nov 1, In : Critical Care Medicine. 24, 11, p. 1869-1873 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
44 Citations (Scopus)

POE incorporation into ionic clusters of ionomer and ion‐conduction behaviors

Takeoka, S., Sakai, H., Shin, H., Ohta, T. & Tsuchida, E., 1991, In : Polymers for Advanced Technologies. 2, 2, p. 69-74 6 p.

Research output: Contribution to journalArticle

Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state

Sakai, H., Tomiyama, K. I., Sou, K., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 425-432 8 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles

Sou, K., Endo, T., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 372-379 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Polylactic acid nanosheets in prevention of postoperative intestinal adhesion and their effects on bacterial propagation in an experimental model

Hinoki, A., Saito, A., Kinoshita, M., Yamamoto, J., Saitoh, D. & Takeoka, S., 2016 May 1, In : British Journal of Surgery. 103, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Polymerization of Diene-Containing Lipids as Liposomes by Radical Initiators. 4. Effect of Lipid Packing on the Polymerization Profile

Ohno, H., Takeoka, S., Iwai, H. & Tsuchida, E., 1988 Mar 1, In : Macromolecules. 21, 2, p. 319-322 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
19 Citations (Scopus)

Polymerization of liposomes evaluated from molecular weight distribution of diene-type phospholipid polymers

Takeoka, S., Kimura, N., Ohno, H. & Tsuchida, E., 1990 Oct, In : Polymer Journal. 22, 10, p. 867-874 8 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)