• 6719 Citations
  • 44 h-Index
1985 …2020

Research output per year

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Research Output

1997

Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats

Sakai, H., Takeoka, S., Park, S. I., Kose, T., Nishide, H., Izumi, Y., Yoshizu, A., Kobayashi, K. & Tsuchida, E., 1997 Jan 1, In : Bioconjugate Chemistry. 8, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

The oxygen carrying capability of hemoglobin vesicles evaluated in rat exchange transfusion models

Kobayashi, K., Izumi, Y., Yoshizu, A., Horinouchi, H., Park, S. I., Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1997 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 25, 4, p. 357-366 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1998

Antioxidative Dopant for Thermal-Resisting Polypyrrole and Its Mechanism

Takeoka, S., Hara, T., Fukushima, K., Yamamoto, K. & Tsuchida, E., 1998 Jun, In : Bulletin of the Chemical Society of Japan. 71, 6, p. 1471-1476 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Disk-like assemblies of a synthetic glycolipid and their association with concanavalin A

Takeoka, S., Sou, K., Ohgushi, T. & Tsuchida, E., 1998 Jan 1, In : Supramolecular Science. 5, 1-2, p. 159-162 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T. & Suematsu, M., 1998 Feb 1, In : Journal of Clinical Investigation. 101, 3, p. 604-612 9 p.

Research output: Contribution to journalArticle

Open Access
241 Citations (Scopus)

Effects of the pH-controlled hemoglobin vesicles by CO2 gas

Park, S., Kose, T., Hamasaki, M., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 497-506 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Human serum albumin-bound synthetic hemes as an oxygen carrier: Determination of equilibrium constants for heme binding to host albumin

Komatsu, T., Hamamatsu, K., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 519-527 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oxygen releasing from cellular hemoglobin

Kawai, N., Ohkawa, H., Maejima, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 507-517 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Physical properties and packing states of molecular assemblies of synthetic glycolipids in aqueous dispersions

Takeoka, S., Sou, K., Boettcher, C., Fuhrhop, J. H. & Tsuchida, E., 1998 Aug 7, In : Journal of the Chemical Society - Faraday Transactions. 94, 15, p. 2151-2158 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Subcutaneous microvasuclar-responses to hemodilution with a red cell substitute consisting of polyethyleneglycol-modified vesicles encapsulating hemoglobin

Sakai, H., Tsai, A. G., Kerger, H., Park, S. I., Takeoka, S., Nishide, H., Tsuchida, E. & Intaglietta, M., 1998 Apr, In : Journal of Biomedical Materials Research. 40, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
1999

Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Kyokane, T., Goda, N., Yamaguchi, T., Takeoka, S., Tsuchida, E., Suematsu, M. & Ishimura, Y., 1999 Nov 1, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 5 40-5, p. G1088-G1096

Research output: Contribution to journalArticle

62 Citations (Scopus)

Lipidheme vesicles and hemoglobin vesicles as dioxygen infusion

Komatsu, T., Takeoka, S., Sakai, H. & Tsuchida, E., 1999 Mar 1, In : American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 40, 1, 1 p.

Research output: Contribution to journalConference article

Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: Influence of O2 affinity

Sakai, H., Tsai, A. G., Rohlfs, R. J., Hara, H., Takeoka, S., Tsuchida, E. & Intaglietta, M., 1999 Feb 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 276, 2 45-2, p. H553-H562

Research output: Contribution to journalArticle

86 Citations (Scopus)

Nonaqueous proton conduction in poly(thiophenylenesulfonic acid)/poly(oxyethylene) composite

Miyatake, K., Fukushima, K., Takeoka, S. & Tsuchida, E., 1999 Jan 1, In : Chemistry of Materials. 11, 5, p. 1171-1173 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Photoexcitation and Electron Transfer Reactions of Zinc Lipidporphyrins in DMSO

Ohgushi, T., Li, Z. C., Li, F. M., Komatsu, T., Takeoka, S. & Tsuchida, E., 1999 Jan, In : Journal of Porphyrins and Phthalocyanines. 3, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Preparation and properties of polyaniline doped with poly(thiophenylenesulfonic acid)

Miyatake, K., Cho, J. S., Takeoka, S. & Tsuchida, E., 1999 Jan 1, In : Macromolecular Chemistry and Physics. 200, 12, p. 2597-2601 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2000

Conjugation of von Willebrand factor-binding domain of platelet glycoprotein Ibα to size-controlled albumin microspheres

Takeoka, S., Teramura, Y., Ohkawa, H., Ikeda, Y. & Tsuchida, E., 2000 Jan 1, In : Biomacromolecules. 1, 2, p. 290-295 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension

Sakai, H., Hara, H., Yuasa, M., Tsai, A. G., Takeoka, S., Tsuchida, E. & Intaglietta, M., 2000 Oct 4, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 3 48-3, p. H908-H915

Research output: Contribution to journalArticle

170 Citations (Scopus)

Photoreduction of methemoglobin by irradiation in the near-ultraviolet region

Sakai, H., Onuma, H., Umeyama, M., Takeoka, S. & Tsuchida, E., 2000 Nov 28, In : Biochemistry. 39, 47, p. 14595-14602 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state

Sakai, H., Tomiyama, K. I., Sou, K., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 425-432 8 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles

Sou, K., Endo, T., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 372-379 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Proton-conduction in poly(alkylenecarbonate)/poly(thiophenylenesulfonic acid) composites

Cho, J. S., Hayashino, Y., Miyatake, K., Takeoka, S. & Tsuchida, E., 2000 Aug 1, In : Polymers for Advanced Technologies. 11, 8-12, p. 548-552 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Proton-conduction of perfluorooctanesulfonic acid / poly(propylene carbonate) composites

Cho, J. S., Hayashino, Y., Miyatake, K., Takeoka, S. & Tsuchida, E., 2000 Jan 1, In : Chemistry Letters. 1, p. 44-45 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and assembly of poly(ethylene glycol) - Lipids with mono-, di-, and tetraacyl chains and a poly(ethylene glycol) chain of various molecular weights

Takeoka, S., Mori, K., Ohkawa, H., Sou, K. & Tsuchida, E., 2000 Aug 23, In : Journal of the American Chemical Society. 122, 33, p. 7927-7935 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Synthesis and physicochemical characterization of a series of hemoglobin-based oxygen carriers: Objective comparison between cellular and acellular types

Sakai, H., Yuasa, M., Onuma, H., Takeoka, S. & Tsuchida, E., 2000 Jan 1, In : Bioconjugate Chemistry. 11, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Synthesis of multiacyl poly(ethylene glycol) for the conjugation of cytochrome c to phospholipid vesicle

Ohkawa, H., Teramura, Y., Takeoka, S. & Tsuchida, E., 2000 Dec 12, In : Bioconjugate Chemistry. 11, 6, p. 815-821 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2001

Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver

Kyokane, T., Norimizu, S., Taniai, H., Yamaguchi, T., Takeoka, S., Tsuchida, E., Naito, M., Nimura, Y., Ishimura, Y. & Suematsu, M., 2001 Jan 1, In : Gastroenterology. 120, 5, p. 1227-1240 14 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Effects of poly(Ethyleneglycol)-modified hemoglobin vesicles on agonist-induced platelet aggregation and rantes release in vitro

Wakamoto, S., Fujihara, M., Abe, H., Sakai, H., Takeoka, S., Tsuchida, E., Ikeda, H. & Ikebuchi, K., 2001 May 22, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 3, p. 191-201 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucyl-phenylalanine-induced responses of polymorphonuclear neutrophils in vitro

Ito, T., Fujihara, M., Abe, H., Yamaguchi, M., Wakamoto, S., Takeoka, S., Sakai, H., Tsuchida, E., Ikeda, H. & Ikebuchi, K., 2001 Dec 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 6, p. 427-437 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Fibrinogen-conjugated albumin polymers and their interaction with platelets under flow conditions

Takeoka, S., Teramura, Y., Okamura, Y., Handa, M., Ikeda, Y. & Tsuchida, E., 2001 Dec 1, In : Biomacromolecules. 2, 4, p. 1192-1197 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Hemoglobin-vesicles as oxygen carriers: Influence on phagocytic activity and histopathological changes in reticuloendothelial system

Sakai, H., Horinouchi, H., Tomiyama, K., Ikeda, E., Takeoka, S., Kobayashi, K. & Tsuchida, E., 2001, In : American Journal of Pathology. 159, 3, p. 1079-1088 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Synthesis of disulfide-containing aniline and copolymerization with aniline

Cho, J. S., Sato, S., Takeoka, S. & Tsuchida, E., 2001 Apr 24, In : Macromolecules. 34, 9, p. 2751-2756 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The 5th International Symposium on Polymers for Advances Technologies (PAT99-Tokyo)

Ohno, H., Takeoka, S. & Oyaizu, K., 2001 Jan 1, In : Polymer News. 26, 1, 1 p.

Research output: Contribution to journalArticle

Virus inactivation in hemoglobin solution by heat treatment

Abe, H., Ikebuchi, K., Hirayama, J., Fujihara, M., Takeoka, S., Sakai, H., Tsuchida, E. & Ikeda, H., 2001 Nov 14, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 5, p. 381-388 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2002

Carbonylation of oxyhemoglobin solution (HbO2 → HbCO) using a membrane oxygenator

Fukutomi, I., Sakai, H., Takeoka, S., Tsuchida, E. & Sakai, K., 2002 Jul 17, In : Journal of Artificial Organs. 5, 2, p. 102-107 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Characteristics of bovine hemoglobin as a potential source of hemoglobin-vesicles for an artificial oxygen carrier

Sakai, H., Masada, Y., Takeoka, S. & Tsuchida, E., 2002 Jan 1, In : Journal of biochemistry. 131, 4, p. 611-617 7 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Complete deoxygenation from a Hemoglobin solution by an electrochemical method and heat treatment for virus inactivation

Ikebuchi, K., Sakai, H., Takeoka, S., Huang, Y., Tsuchida, E., Ikeda, H., Hirayama, J. & Abe, H., 2002 Jan 1, In : Biotechnology Progress. 18, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Effect of Hb-encapsulation with vesicles on H2O2 reaction and lipid peroxidation

Takeoka, S., Teramura, Y., Atoji, T. & Tsuchida, E., 2002 Nov 1, In : Bioconjugate Chemistry. 13, 6, p. 1302-1308 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Erratum: Virus inactivation in hemoglobin solution by heat treatment (Artificial Cells, Blood Subsitutes, and Immobilization Biotechnology (29:5) (381-388))

Abe, H., Ikebuchi, K., Hirayama, J., Fujihara, M., Takeoka, S., Sakai, H., Tsuchida, E. & Ikeda, H., 2002 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 30, 1, 1 p.

Research output: Contribution to journalComment/debate

Rolling properties of rGPIBα-conjugated phospholipid vesicles with different membrane flexibilities on vWf surface under flow conditions

Takeoka, S., Teramura, Y., Okamura, Y., Tsuchida, E., Handa, M. & Ikeda, Y., 2002 Oct 16, In : Biochemical and Biophysical Research Communications. 296, 3, p. 765-770 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles

Sakai, H., Takeoka, S., Wettstein, R., Tsai, A. G., Intaglietta, M. & Tsuchida, E., 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 3 52-3, p. H1191-H1199

Research output: Contribution to journalArticle

60 Citations (Scopus)

Virus removal from hemoglobin solution using planova membrane

Naito, Y., Fukutomi, I., Masada, Y., Sakai, H., Takeoka, S., Tsuchida, E., Abe, H., Hirayama, J., Ikebuchi, K. & Ikeda, H., 2002 Jul 17, In : Journal of Artificial Organs. 5, 2, p. 141-145 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2003

A Duplex of Tetra(2-pyridyl)porphyrin and Tetrahydroxylcalix[4]arene

Ohkawa, H., Arai, S., Takeoka, S., Shibue, T. & Nishide, H., 2003 Nov 5, In : Chemistry Letters. 32, 11, p. 1052-1053 2 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effective Encapsulation of Proteins into Size-Controlled Phospholipid Vesicles Using Freeze-Thawing and Extrusion

Sou, K., Naito, Y., Endo, T., Takeoka, S. & Tsuchida, E., 2003 Sep 1, In : Biotechnology Progress. 19, 5, p. 1547-1552 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Function of fibrinogen γ-chain dodecapeptide-conjugated latex beads under flow

Takeoka, S., Okamura, Y., Teramura, Y., Watanabe, N., Suzuki, H., Tsuchida, E., Handa, M. & Ikeda, Y., 2003 Dec 19, In : Biochemical and Biophysical Research Communications. 312, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Hemoglobin-vesicles as oxygen carriers: Influence on phagocytic activity and histopathological changes in reticuloendothelial system

Horinouchi, H., Kobayashi, K., Sakai, H., Tomiyama, K., Takeoka, S., Tsuchida, E. & Ikeda, E., 2003, In : Keio Journal of Medicine. 52, p. 44-49 6 p.

Research output: Contribution to journalArticle

Hemostatic effects of polymerized albumin particles bearing rGPIa/IIa in thrombocytopenic mice

Teramura, Y., Okamura, Y., Takeoka, S., Tsuchiyama, H., Narumi, H., Kainoh, M., Handa, M., Ikeda, Y. & Tsuchida, E., 2003 Jun 20, In : Biochemical and Biophysical Research Communications. 306, 1, p. 256-260 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity

Contaldo, C., Schramm, S., Wettstein, R., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M., Banic, A. & Erni, D., 2003 Sep 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 3 54-3, p. H1140-H1147

Research output: Contribution to journalArticle

25 Citations (Scopus)

Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue

Erni, D., Wettstein, R., Schramm, S., Contaldo, C., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M. & Banic, A., 2003 May 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 5 53-5, p. H1702-H1709

Research output: Contribution to journalArticle

24 Citations (Scopus)

O2 release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: Comparison with RBCs and acellular Hbs

Sakai, H., Suzuki, Y., Kinoshita, M., Takeoka, S., Maeda, N. & Tsuchida, E., 2003 Dec, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 6 54-6, p. H2543-H2551

Research output: Contribution to journalArticle

34 Citations (Scopus)