• 6648 Citations
  • 43 h-Index
1985 …2020

Research output per year

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Research Output

2003

Pretreatment of serum containing hemoglobin vesicles (oxygen carriers) to prevent their interference in laboratory tests

Sakai, H., Tomiyama, K., Masada, Y., Takeoka, S., Horinouchi, H., Kobayashi, K. & Tsuchida, E., 2003 Mar 27, In : Clinical Chemistry and Laboratory Medicine. 41, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Prolonged Oxygen-Carrying Ability of Hemoglobin Vesicles by Coencapsulation of Catalase in Vivo

Teramura, Y., Kanazawa, H., Sakai, H., Takeoka, S. & Tsuchida, E., 2003 Nov 1, In : Bioconjugate Chemistry. 14, 6, p. 1171-1176 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Safety of artificial oxygen carrier (synthetic erythrocytes) and the ability to supply oxygen to tissues

Tsuchida, H., So, K., Sakai, H., Komatsu, K., Takeoka, S., Horinouchi, H., Suematsu, M. & Kobayashi, K., 2003 Dec 1, In : Masui. The Japanese journal of anesthesiology. 52 Suppl, p. S55-66

Research output: Contribution to journalReview article

1 Citation (Scopus)
2004

3-Dithiolthione-substituted polythiophene and its redox activities

Takemura, I., Iwasaki, T., Takeoka, S. & Nishide, H., 2004 Nov 5, In : Chemistry Letters. 33, 11, p. 1482-1483 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Detection of Lipopolysaccharide in Hemoglobin-Vesicles by Limulus Amebocyte Lysate Test with Kinetic-Turbidimetric Gel Clotting Analysis and Pretreatment of Surfactant

Sakai, H., Hisamoto, S., Fukutomi, I., Sou, K., Takeoka, S. & Tsuchida, E., 2004 Feb, In : Journal of Pharmaceutical Sciences. 93, 2, p. 310-321 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats

Sakai, H., Masada, Y., Horinouchi, H., Yamamoto, M., Ikeda, E., Takeoka, S., Kobayashi, K. & Tsuchida, E., 2004 Feb 1, In : Critical Care Medicine. 32, 2, p. 539-545 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α

Yoshizu, A., Izumi, Y., Park, S., Sakai, H., Takeoka, S., Horinouchi, H., Ikeda, E., Tsuchida, E. & Kobayashi, K., 2004 Sep 1, In : ASAIO Journal. 50, 5, p. 458-463 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model

Sakai, H., Horinouchi, H., Masada, Y., Takeoka, S., Ikeda, E., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Aug 1, In : Biomaterials. 25, 18, p. 4317-4325 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier

Komatsu, T., Oguro, Y., Teramura, Y., Takeoka, S., Okai, J., Anraku, M., Otagiri, M. & Tsuchida, E., 2004 Nov 18, In : Biochimica et Biophysica Acta - General Subjects. 1675, 1-3, p. 21-31 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Sakai, H., Masada, Y., Horinouchi, H., Ikeda, E., Sou, K., Takeoka, S., Suematsu, M., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Dec 1, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 874-884 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Reduction of methemoglobin via electron transfer from photoreduced flavin: Restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles

Sakai, H., Masada, Y., Onuma, H., Takeoka, S. & Tsuchida, E., 2004 Sep 1, In : Bioconjugate Chemistry. 15, 5, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Stability of porphyrin-calix[4]arene complexes analyzed by electrospray ionization mass spectrometry

Arai, S., Ishihara, S., Takeoka, S., Ohkawa, H., Shibue, T. & Nishide, H., 2004 Sep 24, In : Rapid Communications in Mass Spectrometry. 18, 18, p. 2065-2068 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2005

Analysis of self-assembly: Porphyrins with uracil and melamine derivatives

Arai, S., Niwa, D., Takeoka, S. & Nishide, H., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Circulatory half-life time of artificial red blood cell (hemoglobin-vesicles) and their distribution to metabolic organs

Sou, K., Goins, B., Phillips, W. T., Sakai, H., Takeoka, S. & Tsuchida, E., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kubota, K., Kanazawa, H., Hisamoto, S. & Takeoka, S., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Design of nanoparticles for infusing large amounts as artificial blood and their properties

Takeoka, S., 2005 Dec 1, p. 3042-3043. 2 p.

Research output: Contribution to conferencePaper

Developmental trend of artificial blood (artificial red blood cells)

Takeoka, S., 2005 Mar 1, In : Japan Medical Association Journal. 48, 3, p. 135-139 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro

Wakamoto, S., Fujihara, M., Abe, H., Yamaguchi, M., Azuma, H., Ikeda, H., Takeoka, S. & Tsuchida, E., 2005 Jun 15, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 33, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Okamura, Y., Maekawa, I., Fujie, T., Takeoka, S., Handa, M. & Ikeda, Y., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Haemostatic effects of polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide as platelet substitutes in vitro and in vivo

Okamura, Y., Fujie, T., Handa, M., Ikeda, Y. & Takeoka, S., 2005 Dec 1, p. 4933-4934. 2 p.

Research output: Contribution to conferencePaper

Hemostatic effects of fibrinogen γ-chain dodecapeptide-conjugated polymerized albumin particles in vitro and in vivo

Okamura, Y., Takeoka, S., Teramura, Y., Maruyama, H., Tsuchida, E., Handa, M. & Ikeda, Y., 2005 Jul 1, In : Transfusion. 45, 7, p. 1221-1228 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Hemostatic effects of phospholipid vesicles carrying fibrinogen γ chain dodecapeptide in vitro and in vivo

Okamura, Y., Maekawa, I., Teramura, Y., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2005 Nov 1, In : Bioconjugate Chemistry. 16, 6, p. 1589-1596 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Improvement of oxygen carrying ability of hemoglobin vesicles by H 2O 2 elimination system

Atoji, T., Aihara, M., Takeoka, S. & Tsuchida, E., 2005 Dec 1, p. 4927-4928. 2 p.

Research output: Contribution to conferencePaper

Ligand exchange of hemoglobin vesicle with the model device optimized its light response to gas-liquid boundary face more efficient

Suzuki, D., Takeoka, S., Sou, K. & Tsuchida, E., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue

Contaldo, C., Plock, J., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M., Banic, A. & Erni, D., 2005 Apr 1, In : Critical Care Medicine. 33, 4, p. 806-812 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Oxygen infusions (hemoglobin-vesicles and albumin-hemes) based on nano-molecular sciences

Tsuchida, E., Sakai, H., Komatsu, T., Takeoka, S., Huang, Y., Sou, K., Nakagawa, A., Teramura, Y. & Kobayashi, K., 2005 Feb 1, In : Polymers for Advanced Technologies. 16, 2-3, p. 73-83 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution

Cabrales, P., Sakai, H., Tsai, A. G., Takeoka, S., Tsuchida, E. & Intaglietta, M., 2005 Apr 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 4 57-4, p. H1885-H1892

Research output: Contribution to journalArticle

45 Citations (Scopus)

Pharmacokinetics properties of surface-modified vesicles

Sou, K., Coins, B., Phillips, W. T., Takeoka, S. & Tsuchida, E., 2005 Dec 1, p. 3046-3047. 2 p.

Research output: Contribution to conferencePaper

Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Sakai, H., Sou, K., Takeoka, S., Horinouchi, H., Kobayashi, K. & Tsuchida, E., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Porphyrin capped with calix[4]arene derivative via hydrogen bonds

Arai, S., Ohkawa, H., Ishihara, S., Shibue, T., Takeoka, S. & Nishide, H., 2005, In : Bulletin of the Chemical Society of Japan. 78, 11, p. 2007-2013 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Preparation of pH-responsive liposomes with aminolipids

Obata, Y. & Takeoka, S., 2005 Dec 1, p. 4943-4944. 2 p.

Research output: Contribution to conferencePaper

Redox property of 3-dithiolthione-substituted polythiophene and its membrane

Takemura, I., Utsunomiya, S., Takeoka, S. & Nishide, H., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Self-assembly of porphyrins with uracil and melamine derivatives

Arai, S., Niwa, D., Takeoka, S. & Nishide, H., 2005 Dec 1, p. 4913-4914. 2 p.

Research output: Contribution to conferencePaper

Shear dependence of adhesive force of artificial platelet measured by atomic force microscopy

Ogata, A., Fujita, H., Suzuki, K., Takeoka, S., Ikeda, Y. & Tanishita, K., 2005 Dec 1, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 1244-1245 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Suppression effect of methemoglobin formation in hemoglobin vesicles by coencapsulating methemoglobin and L-tyrosine

Atoji, T., Aihara, M., Takeoka, S. & Tsuchida, E., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids

Kubota, K., Okamura, Y. & Takeoka, S., 2005 Dec 1, p. 4939-4940. 2 p.

Research output: Contribution to conferencePaper

Synthesis and characterization of human serum albumin gel

Mochizuki, Y., Okamura, Y. & Takeoka, S., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of cationic aminolipids and characteristic of cationic liposome

Obata, Y. & Takeoka, S., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of Meso substituted uracil porphyrin and the analysis of their assembling structures induced by melamine derivatives

Niwa, D., Arai, S., Takeoka, S. & Nishide, H., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of the columnar-structured ion conductive film by template polymerization

Ishihara, S., Takeoka, S. & Nishide, H., 2005 Dec 1, p. 4298-4299. 2 p.

Research output: Contribution to conferencePaper

2006

Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: Degradation of HbV and erythropoiesis in a rat spleen for 2 weeks

Sakai, H., Horinouchi, H., Yamamoto, M., Ikeda, E., Takeoka, S., Takaori, M., Tsuchida, E. & Kobayashi, K., 2006 Mar 1, In : Transfusion. 46, 3, p. 339-347 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Analysis of ferrylHb radical reduction by L-tyrosine and its application to hemoglobin vesicles

Atoji, T., Yatami, H., Aihara, M., Tsuchida, E. & Takeoka, S., 2006 Oct 19. 1 p.

Research output: Contribution to conferencePaper

Enhancement of hemostatic ability of dodecapeptide-conjugated phospholipid vesicles by encapsulation of a platelet aggregation-induced factor

Okamura, Y., Maekawa, I., Handa, M., Ikeda, Y. & Takeoka, S., 2006 Oct 19. 1 p.

Research output: Contribution to conferencePaper

Evaluation of H2O2 elimination activity by methemoglobin / L-tyrosine and application to hemoglobin vesicles

Aihara, M., Atoji, T. & Takeoka, S., 2006 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Hemoglobin vesicles as a molecular assembly. Characteristics of preparation process and performances as artificial oxygen carriers

Sakai, H., Sou, K., Takeoka, S., Kobayashi, K. & Tsuchida, E., 2006 Dec 1, Blood Substitutes. Elsevier Ltd, p. 514-522 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Hemoglobin vesicles containing methemoglobin and L-tyrosine to suppress methemoglobin formation in vitro and in vivo

Atoji, T., Aihara, M., Sakai, H., Tsuchida, E. & Takeoka, S., 2006 Sep 1, In : Bioconjugate Chemistry. 17, 5, p. 1241-1245 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Host-guest assembly of pyridinium-conjugated calix[4]arene via cation-π interaction

Ishihara, S. & Takeoka, S., 2006 Jan 9, In : Tetrahedron Letters. 47, 2, p. 181-184 4 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Hydrogen-bonded hexagonal columnar liquid crystal composed of triphenylene and dendrons

Ishihara, S., Furuki, Y. & Takeoka, S., 2006 Dec 1, p. 3825-3826. 2 p.

Research output: Contribution to conferencePaper

Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: Effects on coagulation, kallikrein-kinin, and complement systems

Abe, H., Fujihara, M., Azuma, H., Ikeda, H., Ikebuchi, K., Takeoka, S., Tsuchida, E. & Harashima, H., 2006 Apr 1, In : Artificial Cells, Blood Substitutes, and Biotechnology. 34, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
28 Citations (Scopus)