• 6597 Citations
  • 43 h-Index
1985 …2020

Research output per year

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Research Output

2005

Shear dependence of adhesive force of artificial platelet measured by atomic force microscopy

Ogata, A., Fujita, H., Suzuki, K., Takeoka, S., Ikeda, Y. & Tanishita, K., 2005 Dec 1, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 1244-1245 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Suppression effect of methemoglobin formation in hemoglobin vesicles by coencapsulating methemoglobin and L-tyrosine

Atoji, T., Aihara, M., Takeoka, S. & Tsuchida, E., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids

Kubota, K., Okamura, Y. & Takeoka, S., 2005 Dec 1, p. 4939-4940. 2 p.

Research output: Contribution to conferencePaper

Synthesis and characterization of human serum albumin gel

Mochizuki, Y., Okamura, Y. & Takeoka, S., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of cationic aminolipids and characteristic of cationic liposome

Obata, Y. & Takeoka, S., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of Meso substituted uracil porphyrin and the analysis of their assembling structures induced by melamine derivatives

Niwa, D., Arai, S., Takeoka, S. & Nishide, H., 2005 Dec 1. 1 p.

Research output: Contribution to conferencePaper

Synthesis of the columnar-structured ion conductive film by template polymerization

Ishihara, S., Takeoka, S. & Nishide, H., 2005 Dec 1, p. 4298-4299. 2 p.

Research output: Contribution to conferencePaper

2004

3-Dithiolthione-substituted polythiophene and its redox activities

Takemura, I., Iwasaki, T., Takeoka, S. & Nishide, H., 2004 Nov 5, In : Chemistry Letters. 33, 11, p. 1482-1483 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Detection of Lipopolysaccharide in Hemoglobin-Vesicles by Limulus Amebocyte Lysate Test with Kinetic-Turbidimetric Gel Clotting Analysis and Pretreatment of Surfactant

Sakai, H., Hisamoto, S., Fukutomi, I., Sou, K., Takeoka, S. & Tsuchida, E., 2004 Feb, In : Journal of Pharmaceutical Sciences. 93, 2, p. 310-321 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats

Sakai, H., Masada, Y., Horinouchi, H., Yamamoto, M., Ikeda, E., Takeoka, S., Kobayashi, K. & Tsuchida, E., 2004 Feb 1, In : Critical Care Medicine. 32, 2, p. 539-545 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-α

Yoshizu, A., Izumi, Y., Park, S., Sakai, H., Takeoka, S., Horinouchi, H., Ikeda, E., Tsuchida, E. & Kobayashi, K., 2004 Sep 1, In : ASAIO Journal. 50, 5, p. 458-463 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model

Sakai, H., Horinouchi, H., Masada, Y., Takeoka, S., Ikeda, E., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Aug 1, In : Biomaterials. 25, 18, p. 4317-4325 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier

Komatsu, T., Oguro, Y., Teramura, Y., Takeoka, S., Okai, J., Anraku, M., Otagiri, M. & Tsuchida, E., 2004 Nov 18, In : Biochimica et Biophysica Acta - General Subjects. 1675, 1-3, p. 21-31 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Sakai, H., Masada, Y., Horinouchi, H., Ikeda, E., Sou, K., Takeoka, S., Suematsu, M., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Dec 1, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 874-884 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Reduction of methemoglobin via electron transfer from photoreduced flavin: Restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles

Sakai, H., Masada, Y., Onuma, H., Takeoka, S. & Tsuchida, E., 2004 Sep 1, In : Bioconjugate Chemistry. 15, 5, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Stability of porphyrin-calix[4]arene complexes analyzed by electrospray ionization mass spectrometry

Arai, S., Ishihara, S., Takeoka, S., Ohkawa, H., Shibue, T. & Nishide, H., 2004 Sep 24, In : Rapid Communications in Mass Spectrometry. 18, 18, p. 2065-2068 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2003

A Duplex of Tetra(2-pyridyl)porphyrin and Tetrahydroxylcalix[4]arene

Ohkawa, H., Arai, S., Takeoka, S., Shibue, T. & Nishide, H., 2003 Nov 5, In : Chemistry Letters. 32, 11, p. 1052-1053 2 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effective Encapsulation of Proteins into Size-Controlled Phospholipid Vesicles Using Freeze-Thawing and Extrusion

Sou, K., Naito, Y., Endo, T., Takeoka, S. & Tsuchida, E., 2003 Sep 1, In : Biotechnology Progress. 19, 5, p. 1547-1552 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Function of fibrinogen γ-chain dodecapeptide-conjugated latex beads under flow

Takeoka, S., Okamura, Y., Teramura, Y., Watanabe, N., Suzuki, H., Tsuchida, E., Handa, M. & Ikeda, Y., 2003 Dec 19, In : Biochemical and Biophysical Research Communications. 312, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Hemoglobin-vesicles as oxygen carriers: Influence on phagocytic activity and histopathological changes in reticuloendothelial system

Horinouchi, H., Kobayashi, K., Sakai, H., Tomiyama, K., Takeoka, S., Tsuchida, E. & Ikeda, E., 2003, In : Keio Journal of Medicine. 52, p. 44-49 6 p.

Research output: Contribution to journalArticle

Hemostatic effects of polymerized albumin particles bearing rGPIa/IIa in thrombocytopenic mice

Teramura, Y., Okamura, Y., Takeoka, S., Tsuchiyama, H., Narumi, H., Kainoh, M., Handa, M., Ikeda, Y. & Tsuchida, E., 2003 Jun 20, In : Biochemical and Biophysical Research Communications. 306, 1, p. 256-260 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity

Contaldo, C., Schramm, S., Wettstein, R., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M., Banic, A. & Erni, D., 2003 Sep 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 3 54-3, p. H1140-H1147

Research output: Contribution to journalArticle

25 Citations (Scopus)

Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue

Erni, D., Wettstein, R., Schramm, S., Contaldo, C., Sakai, H., Takeoka, S., Tsuchida, E., Leunig, M. & Banic, A., 2003 May 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 5 53-5, p. H1702-H1709

Research output: Contribution to journalArticle

24 Citations (Scopus)

O2 release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: Comparison with RBCs and acellular Hbs

Sakai, H., Suzuki, Y., Kinoshita, M., Takeoka, S., Maeda, N. & Tsuchida, E., 2003 Dec, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 6 54-6, p. H2543-H2551

Research output: Contribution to journalArticle

34 Citations (Scopus)

Pretreatment of serum containing hemoglobin vesicles (oxygen carriers) to prevent their interference in laboratory tests

Sakai, H., Tomiyama, K., Masada, Y., Takeoka, S., Horinouchi, H., Kobayashi, K. & Tsuchida, E., 2003 Mar 27, In : Clinical Chemistry and Laboratory Medicine. 41, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Prolonged Oxygen-Carrying Ability of Hemoglobin Vesicles by Coencapsulation of Catalase in Vivo

Teramura, Y., Kanazawa, H., Sakai, H., Takeoka, S. & Tsuchida, E., 2003 Nov 1, In : Bioconjugate Chemistry. 14, 6, p. 1171-1176 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Safety of artificial oxygen carrier (synthetic erythrocytes) and the ability to supply oxygen to tissues

Tsuchida, H., So, K., Sakai, H., Komatsu, K., Takeoka, S., Horinouchi, H., Suematsu, M. & Kobayashi, K., 2003 Dec 1, In : Masui. The Japanese journal of anesthesiology. 52 Suppl, p. S55-66

Research output: Contribution to journalReview article

1 Citation (Scopus)
2002

Carbonylation of oxyhemoglobin solution (HbO2 → HbCO) using a membrane oxygenator

Fukutomi, I., Sakai, H., Takeoka, S., Tsuchida, E. & Sakai, K., 2002 Jul 17, In : Journal of Artificial Organs. 5, 2, p. 102-107 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Characteristics of bovine hemoglobin as a potential source of hemoglobin-vesicles for an artificial oxygen carrier

Sakai, H., Masada, Y., Takeoka, S. & Tsuchida, E., 2002 Jan 1, In : Journal of biochemistry. 131, 4, p. 611-617 7 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Complete deoxygenation from a Hemoglobin solution by an electrochemical method and heat treatment for virus inactivation

Ikebuchi, K., Sakai, H., Takeoka, S., Huang, Y., Tsuchida, E., Ikeda, H., Hirayama, J. & Abe, H., 2002 Jan 1, In : Biotechnology Progress. 18, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Effect of Hb-encapsulation with vesicles on H2O2 reaction and lipid peroxidation

Takeoka, S., Teramura, Y., Atoji, T. & Tsuchida, E., 2002 Nov 1, In : Bioconjugate Chemistry. 13, 6, p. 1302-1308 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Erratum: Virus inactivation in hemoglobin solution by heat treatment (Artificial Cells, Blood Subsitutes, and Immobilization Biotechnology (29:5) (381-388))

Abe, H., Ikebuchi, K., Hirayama, J., Fujihara, M., Takeoka, S., Sakai, H., Tsuchida, E. & Ikeda, H., 2002 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 30, 1, 1 p.

Research output: Contribution to journalComment/debate

Rolling properties of rGPIBα-conjugated phospholipid vesicles with different membrane flexibilities on vWf surface under flow conditions

Takeoka, S., Teramura, Y., Okamura, Y., Tsuchida, E., Handa, M. & Ikeda, Y., 2002 Oct 16, In : Biochemical and Biophysical Research Communications. 296, 3, p. 765-770 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles

Sakai, H., Takeoka, S., Wettstein, R., Tsai, A. G., Intaglietta, M. & Tsuchida, E., 2002 Jan 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 3 52-3, p. H1191-H1199

Research output: Contribution to journalArticle

60 Citations (Scopus)

Virus removal from hemoglobin solution using planova membrane

Naito, Y., Fukutomi, I., Masada, Y., Sakai, H., Takeoka, S., Tsuchida, E., Abe, H., Hirayama, J., Ikebuchi, K. & Ikeda, H., 2002 Jul 17, In : Journal of Artificial Organs. 5, 2, p. 141-145 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2001

Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver

Kyokane, T., Norimizu, S., Taniai, H., Yamaguchi, T., Takeoka, S., Tsuchida, E., Naito, M., Nimura, Y., Ishimura, Y. & Suematsu, M., 2001 Jan 1, In : Gastroenterology. 120, 5, p. 1227-1240 14 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Effects of poly(Ethyleneglycol)-modified hemoglobin vesicles on agonist-induced platelet aggregation and rantes release in vitro

Wakamoto, S., Fujihara, M., Abe, H., Sakai, H., Takeoka, S., Tsuchida, E., Ikeda, H. & Ikebuchi, K., 2001 May 22, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 3, p. 191-201 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucyl-phenylalanine-induced responses of polymorphonuclear neutrophils in vitro

Ito, T., Fujihara, M., Abe, H., Yamaguchi, M., Wakamoto, S., Takeoka, S., Sakai, H., Tsuchida, E., Ikeda, H. & Ikebuchi, K., 2001 Dec 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 6, p. 427-437 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Fibrinogen-conjugated albumin polymers and their interaction with platelets under flow conditions

Takeoka, S., Teramura, Y., Okamura, Y., Handa, M., Ikeda, Y. & Tsuchida, E., 2001 Dec 1, In : Biomacromolecules. 2, 4, p. 1192-1197 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Hemoglobin-vesicles as oxygen carriers: Influence on phagocytic activity and histopathological changes in reticuloendothelial system

Sakai, H., Horinouchi, H., Tomiyama, K., Ikeda, E., Takeoka, S., Kobayashi, K. & Tsuchida, E., 2001 Jan 1, In : American Journal of Pathology. 159, 3, p. 1079-1088 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Synthesis of disulfide-containing aniline and copolymerization with aniline

Cho, J. S., Sato, S., Takeoka, S. & Tsuchida, E., 2001 Apr 24, In : Macromolecules. 34, 9, p. 2751-2756 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The 5th International Symposium on Polymers for Advances Technologies (PAT99-Tokyo)

Ohno, H., Takeoka, S. & Oyaizu, K., 2001 Jan 1, In : Polymer News. 26, 1, 1 p.

Research output: Contribution to journalArticle

Virus inactivation in hemoglobin solution by heat treatment

Abe, H., Ikebuchi, K., Hirayama, J., Fujihara, M., Takeoka, S., Sakai, H., Tsuchida, E. & Ikeda, H., 2001 Nov 14, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 29, 5, p. 381-388 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2000

Conjugation of von Willebrand factor-binding domain of platelet glycoprotein Ibα to size-controlled albumin microspheres

Takeoka, S., Teramura, Y., Ohkawa, H., Ikeda, Y. & Tsuchida, E., 2000 Jan 1, In : Biomacromolecules. 1, 2, p. 290-295 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension

Sakai, H., Hara, H., Yuasa, M., Tsai, A. G., Takeoka, S., Tsuchida, E. & Intaglietta, M., 2000 Oct 4, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 3 48-3, p. H908-H915

Research output: Contribution to journalArticle

167 Citations (Scopus)

Photoreduction of methemoglobin by irradiation in the near-ultraviolet region

Sakai, H., Onuma, H., Umeyama, M., Takeoka, S. & Tsuchida, E., 2000 Nov 28, In : Biochemistry. 39, 47, p. 14595-14602 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state

Sakai, H., Tomiyama, K. I., Sou, K., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 425-432 8 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles

Sou, K., Endo, T., Takeoka, S. & Tsuchida, E., 2000 May 1, In : Bioconjugate Chemistry. 11, 3, p. 372-379 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Proton-conduction in poly(alkylenecarbonate)/poly(thiophenylenesulfonic acid) composites

Cho, J. S., Hayashino, Y., Miyatake, K., Takeoka, S. & Tsuchida, E., 2000 Aug 1, In : Polymers for Advanced Technologies. 11, 8-12, p. 548-552 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Proton-conduction of perfluorooctanesulfonic acid / poly(propylene carbonate) composites

Cho, J. S., Hayashino, Y., Miyatake, K., Takeoka, S. & Tsuchida, E., 2000 Jan 1, In : Chemistry Letters. 1, p. 44-45 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)