• 6597 Citations
  • 43 h-Index
1985 …2020

Research output per year

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Research Output

2000

Synthesis and assembly of poly(ethylene glycol) - Lipids with mono-, di-, and tetraacyl chains and a poly(ethylene glycol) chain of various molecular weights

Takeoka, S., Mori, K., Ohkawa, H., Sou, K. & Tsuchida, E., 2000 Aug 23, In : Journal of the American Chemical Society. 122, 33, p. 7927-7935 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Synthesis and physicochemical characterization of a series of hemoglobin-based oxygen carriers: Objective comparison between cellular and acellular types

Sakai, H., Yuasa, M., Onuma, H., Takeoka, S. & Tsuchida, E., 2000 Jan 1, In : Bioconjugate Chemistry. 11, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Synthesis of multiacyl poly(ethylene glycol) for the conjugation of cytochrome c to phospholipid vesicle

Ohkawa, H., Teramura, Y., Takeoka, S. & Tsuchida, E., 2000 Dec 12, In : Bioconjugate Chemistry. 11, 6, p. 815-821 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1999

Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Kyokane, T., Goda, N., Yamaguchi, T., Takeoka, S., Tsuchida, E., Suematsu, M. & Ishimura, Y., 1999 Nov 1, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 5 40-5, p. G1088-G1096

Research output: Contribution to journalArticle

62 Citations (Scopus)

Lipidheme vesicles and hemoglobin vesicles as dioxygen infusion

Komatsu, T., Takeoka, S., Sakai, H. & Tsuchida, E., 1999 Mar 1, In : American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 40, 1, 1 p.

Research output: Contribution to journalConference article

Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: Influence of O2 affinity

Sakai, H., Tsai, A. G., Rohlfs, R. J., Hara, H., Takeoka, S., Tsuchida, E. & Intaglietta, M., 1999 Feb 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 276, 2 45-2, p. H553-H562

Research output: Contribution to journalArticle

86 Citations (Scopus)

Nonaqueous proton conduction in poly(thiophenylenesulfonic acid)/poly(oxyethylene) composite

Miyatake, K., Fukushima, K., Takeoka, S. & Tsuchida, E., 1999 Jan 1, In : Chemistry of Materials. 11, 5, p. 1171-1173 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Photoexcitation and Electron Transfer Reactions of Zinc Lipidporphyrins in DMSO

Ohgushi, T., Li, Z. C., Li, F. M., Komatsu, T., Takeoka, S. & Tsuchida, E., 1999 Jan, In : Journal of Porphyrins and Phthalocyanines. 3, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Preparation and properties of polyaniline doped with poly(thiophenylenesulfonic acid)

Miyatake, K., Cho, J. S., Takeoka, S. & Tsuchida, E., 1999 Jan 1, In : Macromolecular Chemistry and Physics. 200, 12, p. 2597-2601 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
1998

Antioxidative Dopant for Thermal-Resisting Polypyrrole and Its Mechanism

Takeoka, S., Hara, T., Fukushima, K., Yamamoto, K. & Tsuchida, E., 1998 Jun, In : Bulletin of the Chemical Society of Japan. 71, 6, p. 1471-1476 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Disk-like assemblies of a synthetic glycolipid and their association with concanavalin A

Takeoka, S., Sou, K., Ohgushi, T. & Tsuchida, E., 1998 Jan 1, In : Supramolecular Science. 5, 1-2, p. 159-162 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T. & Suematsu, M., 1998 Feb 1, In : Journal of Clinical Investigation. 101, 3, p. 604-612 9 p.

Research output: Contribution to journalArticle

Open Access
241 Citations (Scopus)

Effects of the pH-controlled hemoglobin vesicles by CO2 gas

Park, S., Kose, T., Hamasaki, M., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 497-506 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Human serum albumin-bound synthetic hemes as an oxygen carrier: Determination of equilibrium constants for heme binding to host albumin

Komatsu, T., Hamamatsu, K., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 519-527 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oxygen releasing from cellular hemoglobin

Kawai, N., Ohkawa, H., Maejima, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1998 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26, 5-6, p. 507-517 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Physical properties and packing states of molecular assemblies of synthetic glycolipids in aqueous dispersions

Takeoka, S., Sou, K., Boettcher, C., Fuhrhop, J. H. & Tsuchida, E., 1998 Aug 7, In : Journal of the Chemical Society - Faraday Transactions. 94, 15, p. 2151-2158 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Subcutaneous microvasuclar-responses to hemodilution with a red cell substitute consisting of polyethyleneglycol-modified vesicles encapsulating hemoglobin

Sakai, H., Tsai, A. G., Kerger, H., Park, S. I., Takeoka, S., Nishide, H., Tsuchida, E. & Intaglietta, M., 1998 Apr 1, In : Journal of Biomedical Materials Research. 40, 1, p. 66-78 13 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
1997

Construction of artificial methemoglobin reduction systems in Hb vesicles

Takeoka, S., Ohgushi, T., Sakai, H., Kose, T., Nishide, H. & Tsuchida, E., 1997 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 25, 1-2, p. 31-41 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Evaluation of the capabilities of a hemoglobin vesicle as an artificial oxygen carrier in a rat exchange transfusion model

Izumi, Y., Sakai, H., Kose, T., Hamada, K., Takeoka, S., Yoshizu, A., Horinouchi, H., Kato, R., Nishide, H., Tsuchida, E. & Kobayashi, K., 1997 Aug 1, In : ASAIO Journal. 43, 4, p. 289-297 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Methemoglobin formation in hemoglobin vesicles and reduction by encapsukated thiols

Takeoka, S., Sakai, H., Kose, T., Mano, Y., Seino, Y., Nishide, H. & Tsuchida, E., 1997 Jul 1, In : Bioconjugate Chemistry. 8, 4, p. 539-544 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

O2 binding and dissociation and ligand exchange reaction of O2 with CO in polymer composite films of hemoglobin

Park, S. I., Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1997 Jun, In : Polymers for Advanced Technologies. 8, 6, p. 366-370 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Properties of and oxygen binding by albumin-tetraphenylporphyrinatoiron(II) derivative complexes

Tsuchida, E., Ando, K., Maejima, H., Kawai, N., Komatsu, T., Takeoka, S. & Nishide, H., 1997 Jul 1, In : Bioconjugate Chemistry. 8, 4, p. 534-538 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reduction of methemoglobin via electron transfer across the bilayer membrane of Hb vesicles

Takeoka, S., Ohgushi, T., Nishide, H. & Tsuchida, E., 1997 Dec 1, In : Bulletin of the Chemical Society of Japan. 70, 5, p. 1171-1178 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats

Sakai, H., Takeoka, S., Park, S. I., Kose, T., Nishide, H., Izumi, Y., Yoshizu, A., Kobayashi, K. & Tsuchida, E., 1997 Jan 1, In : Bioconjugate Chemistry. 8, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

The oxygen carrying capability of hemoglobin vesicles evaluated in rat exchange transfusion models

Kobayashi, K., Izumi, Y., Yoshizu, A., Horinouchi, H., Park, S. I., Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1997 Jan 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 25, 4, p. 357-366 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1996

Critical molecular weight effects in the aggregation of phospholipid vesicles triggered by water-soluble polymers and an integrated glycolipid

Takeoka, S., Sou, K., Arase, S., Ohgushi, T. & Tsuchida, E., 1996 Dec 2, In : Macromolecules. 29, 25, p. 8132-8136 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional evaluation of hemoglobin- and lipidheme-vesicles as red cell substitutes

Sakai, H., Hamada, K., Takeoka, S., Nishide, H. & Tsuchida, E., 1996 Aug, In : Polymers for Advanced Technologies. 7, 8, p. 639-644 6 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Layer-controlled hemoglobin vesicles by interaction of hemoglobin with a phospholipid assembly

Takeoka, S., Ohgushi, T., Terase, K., Ohmori, T. & Tsuchida, E., 1996 Apr 3, In : Langmuir. 12, 7, p. 1755-1759 5 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Physical properties of hemoglobin vesicles as red cell substitutes

Sakai, H., Hamada, K., Takeoka, S., Nishide, H. & Tsuchida, E., 1996 Jan 1, In : Biotechnology Progress. 12, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Physiologic responses to exchange transfusion with hemoglobin vesicles as an artificial oxygen carrier in anesthetized rats: Changes in mean arterial pressure and renal cortical tissue oxygen tension

Izumi, Y., Sakai, H., Hamada, K., Takeoka, S., Yamahata, T., Kato, R., Nishide, H., Tsuchida, E. & Kobayashi, K., 1996 Nov 1, In : Critical Care Medicine. 24, 11, p. 1869-1873 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Thermal stabilization of polypyrrole by incorporation of aromatic sulfonate derivatives as dopants

Takeoka, S., Hara, T., Yamamoto, K. & Tsuchida, E., 1996 Jan 1, In : Chemistry Letters. 4, p. 253-254 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1995

Destruction and Reconstitution of Polyphospholipid Vesicles with Size Memory

Takeoka, S., Ohgushi, T. & Tsuchida, E., 1995 Nov 1, In : Macromolecules. 28, 23, p. 7660-7666 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Intermolecular Interactions of Lithocholic Acid Derivatives with Phospholipid as Bilayer Membrane

Li, Z. C., Li, F. M., Arase, S., Takeoka, S. & Tsuchida, E., 1995 Aug 1, In : Langmuir. 11, 8, p. 3161-3166 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ligand Exchange Reaction of Carbonylhemoglobin to Oxyhemoglobin in a Hemoglobin Liquid Membrane

Chung, J. E., Hamada, K., Sakai, H., Takeoka, S. & Tsuchida, E., 1995, In : Nippon Kagaku Kaishi. 1995, 2, p. 123-127 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
1994

A new totally synthetic oxygen carrier: Lipid heme microshere(LHM)

Kobayashi, K., Kakizaki, T., Izumi, Y., Takeoka, S., Komatsu, T., Nishide, H. & Tsuchida, E., 1994 Nov 1, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 22, 5, p. A117

Research output: Contribution to journalConference article

Characteristics of hb-vesicles and encapsulation procedure

Takeoka, S., Sakai, H., Terase, K., Nishide, H. & Tsuchida, E., 1994 Jan, In : Artificial Cells, Blood Substitutes, and Biotechnology. 22, 3, p. 861-866 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Convenient method to purify hemoglobin

Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1994 Jan, In : Artificial Cells, Blood Substitutes, and Biotechnology. 22, 3, p. 651-656 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Interaction between phospholipid assemblies and hemoglobin (hb)

Takeoka, S., Terase, K., Yokohama, H., Sakai, H., Nishide, H. & Tsuchida, E., 1994 Jan 1, In : Journal of Macromolecular Science, Part A. 31, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Modification of Hb-vesicles with oligosaccharide chains

Sakai, H., Takisada, M., Chung, J. E., Takeoka, S. & Tsuchida, E., 1994 Jan 1, In : Japanese Journal of Artificial Organs. 23, 3, p. 864-867 4 p.

Research output: Contribution to journalArticle

Oxygen‐binding property of hemoglobin films

Chung, J., Takeoka, S., Nishide, H. & Tsuchida, E., 1994 Jul, In : Polymers for Advanced Technologies. 5, 7, p. 385-389 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Suppression of metHb formation in Hb-vesicles by glutathione

Yokohama, H., Seino, Y., Chung, J. E., Sakai, H., Takeoka, S., Nishide, H. & Tsuchida, E., 1994 Jan 1, In : Japanese Journal of Artificial Organs. 23, 3, p. 868-871 4 p.

Research output: Contribution to journalArticle

Suppression of methemoglobin formation by glutathione in a concentrated hemoglobin solution and in a hemoglobin-vesicle

Sakai, H., Takeoka, S., Seino, Y. & Tsuchida, E., 1994 Jun 29, In : Bulletin of the Chemical Society of Japan. 67, 4, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1993
1 Citation (Scopus)

Oxidation of a PPy‐modified tantalum electrode

Park, YS. S., Yamamoto, K., Takeoka, S., Ohta, T. & Tsuchida, E., 1993, In : Polymers for Advanced Technologies. 4, 5, p. 329-334 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Preparation conditions of human hemoglobin-vesicles covered with lipid membranes

Takeoka, S., Sakai, H., Tsuchida, E. & Nishide, H., 1993 Jan 1, In : Japanese Journal of Artificial Organs. 22, 2, p. 566-569 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Purification of concentrated hemoglobin using organic solvent and heat treatment

Sakai, H., Takeoka, S., Yokohama, H., Seino, Y., Nishide, H. & Tsuchida, E., 1993 Dec, In : Protein Expression and Purification. 4, 6, p. 563-569 7 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Recent advancement of ion‐conductive polymers

Takeoka, S., Ohno, H. & Tsuchida, E., 1993, In : Polymers for Advanced Technologies. 4, 2-3, p. 53-73 21 p.

Research output: Contribution to journalReview article

94 Citations (Scopus)
1992

A lithium secondary battery using a thin film of polymer electrolyte as a separator

Ohta, T., Takeoka, S., Tsuchida, E., Feng, H. Y., Fu, Z. S. & Wang, Y. P., 1992, In : Polymers for Advanced Technologies. 3, 8, p. 433-436 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Encapsulation of Hb into unsaturated lipid vesicles and γ‐ray polymerization

Sakai, H., Takeoka, S., Yokohama, H., Nishide, H. & Tsuchida, E., 1992, In : Polymers for Advanced Technologies. 3, 7, p. 389-394 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Formation of PPy/Ta2O5/Ta structure by electropolymerization

Park, YS. S., Takeoka, S., Yamamoto, K. & Tsuchida, E., 1992, In : Polymers for Advanced Technologies. 3, 7, p. 395-400 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)