• 1421 Citations
  • 22 h-Index
19972020

Research output per year

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Research Output

  • 1421 Citations
  • 22 h-Index
  • 54 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
2020

Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice

Wang, Z., Komatsu, T., Ohata, Y., Watanabe, Y., Yuan, Y., Yoshii, Y., Park, S., Mori, R., Satou, M., Kondo, Y., Shimokawa, I. & Chiba, T., 2020 Mar 1, In : Geriatrics and Gerontology International. 20, 3, p. 238-247 10 p.

Research output: Contribution to journalArticle

2019

DNA polymerase (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse

Wang, Z., Song, Y., Li, S., Kurian, S., Xiang, R., Chiba, T. & Wu, X., 2019 Mar 15, In : Journal of Biological Chemistry. 294, 11, p. 3909-3919 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures

Li, S., Lu, H., Wang, Z., Hu, Q., Wang, H., Xiang, R., Chiba, T. & Wu, X., 2019 Jun 28, In : iScience. 16, p. 63-78 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2015

Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats

Okita, N., Tsuchiya, T., Fukushima, M., Itakura, K., Yuguchi, K., Narita, T., Hashizume, Y., Sudo, Y., Chiba, T., Shimokawa, I. & Higami, Y., 2015 Mar 1, In : Experimental Gerontology. 63, p. 59-66 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

Kamohara, R., Yamaza, H., Tsuchiya, T., Komatsu, T., Park, S., Hayashi, H., Chiba, T., Mori, R., Otabe, S., Yamada, K., Nagayasu, T. & Shimokawa, I., 2015 Apr 1, In : Experimental Gerontology. 64, p. 46-54 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The life-extending effect of dietary restriction requires Foxo3 in mice

Shimokawa, I., Komatsu, T., Hayashi, N., Kim, S. E., Kawata, T., Park, S., Hayashi, H., Yamaza, H., Chiba, T. & Mori, R., 2015 Aug 1, In : Aging cell. 14, 4, p. 707-709 3 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction

Kim, S. E., Mori, R., Komatsu, T., Chiba, T., Hayashi, H., Park, S., Sugawa, M. D., Dencher, N. A. & Shimokawa, I., 2015 Jun 1, In : Age. 37, 3

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction

Chiba, T., Tamashiro, Y., Park, D., Kusudo, T., Fujie, R., Komatsu, T., Kim, S. E., Park, S., Hayashi, H., Mori, R., Yamashita, H., Chung, H. Y. & Shimokawa, I., 2014 Mar 31, In : Scientific reports. 4, 4517.

Research output: Contribution to journalArticle

20 Citations (Scopus)

NPY antagonism reduces adiposity and attenuates age-related imbalance of adipose tissue metabolism

Park, S., Fujishita, C., Komatsu, T., Kim, S. E., Chiba, T., Mori, R. & Shimokawa, I., 2014 Dec 1, In : FASEB Journal. 28, 12, p. 5337-5348 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Caloric restriction-Associated remodeling of rat white adipose tissue: Effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration

Chujo, Y., Fujii, N., Okita, N., Konishi, T., Narita, T., Yamada, A., Haruyama, Y., Tashiro, K., Chiba, T., Shimokawa, I. & Higami, Y., 2013 Aug, In : Age. 35, 4, p. 1143-1156 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Food and Longevity Genes

Shimokawa, I. & Chiba, T., 2013 Aug 29, Bioactive Food as Dietary Interventions for the Aging Population. Elsevier Inc., p. 61-70 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint

Lee, A. Y. L., Chiba, T., Truong, L. N., Cheng, A. N., Do, J., Cho, M. J., Chen, L. & Wu, X., 2012 Jan 20, In : Journal of Biological Chemistry. 287, 4, p. 2531-2543 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Protein reporter bioassay systems for the phenotypic screening of candidate drugs: A mouse platform for anti-aging drug screening

Chiba, T., Tsuchiya, T., Mori, R. & Shimokawa, I., 2012 Feb, In : Sensors. 12, 2, p. 1648-1656 9 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2011

Acute stress response modified by modest inhibition of growth hormone axis: A potential machinery of the anti-aging effect of calorie restriction

Komatsu, T., Trindade, L. S., Chiba, T., Hayashi, H., Henmi, T., Ushiroda, Y., Mori, R. & Shimokawa, I., 2011 Mar, In : Mechanisms of Ageing and Development. 132, 3, p. 103-109 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Down-regulation of hepatic AMP-activated protein kinase and up-regulation of CREB coactivator CRTC2 for gluconeogenesis under calorie-restricted conditions at a young age

Trindade, L. S., Park, S. J., Komatsu, T., Yamaza, H., Hayashi, H., Mori, R., Chiba, T., Shimokawa, I. & Kuramoto, K., 2011, In : Acta Medica Nagasakiensia. 55, 2, p. 85-92 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction

Hayashida, T., Komatsu, T., Henmi, Y., Yanagihara-Ota, K., Kim, A. R., Chiba, T., Goto, S., Chung, H. Y. & Shimokawa, I., 2011 Oct, In : Geriatrics and Gerontology International. 11, 4, p. 496-503 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Release of TNF-α from macrophages is mediated by small GTPase Rab37

Mori, R., Ikematsu, K., Kitaguchi, T., Kim, S. E., Okamoto, M., Chiba, T., Miyawaki, A., Shimokawa, I. & Tsuboi, T., 2011 Nov 1, In : European Journal of Immunology. 41, 11, p. 3230-3239 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction

Chiba, T., Tsuchiya, T., Komatsu, T., Mori, R., Hayashi, H., Shimano, H., Spindler, S. R. & Shimokawa, I., 2010 Oct 15, In : Biochemical and Biophysical Research Communications. 401, 2, p. 213-218 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases

Chiba, T., Tsuchiya, T., Komatsu, T., Mori, R., Hayashi, H. & Shimokawa, I., 2010 Dec 16, In : Current Genomics. 11, 8, p. 562-567 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

FoxO1 is involved in the antineoplastic effect of calorie restriction

Yamaza, H., Komatsu, T., Wakita, S., Kijogi, C., Park, S., Hayashi, H., Chiba, T., Mori, R., Furuyama, T., Mori, N. & Shimokawa, I., 2010 Jun, In : Aging cell. 9, 3, p. 372-382 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals

Akieda-Asai, S., Zaima, N., Ikegami, K., Kahyo, T., Yao, I., Hatanaka, T., Iemura, S. I., Sugiyama, R., Yokozeki, T., Eishi, Y., Koike, M., Ikeda, K., Chiba, T., Yamaza, H., Shimokawa, I., Song, S. Y., Matsuno, A., Mizutani, A., Sawabe, M., Chao, M. V. & 8 others, Tanaka, M., Kanaho, Y., Natsume, T., Sugimura, H., Date, Y., Mcburney, M. W., Guarente, L. & Setou, M., 2010, In : PloS one. 5, 7, e11755.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2009

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Shimokawa, I., Utsuyama, M., Komatsu, T., Yamaza, H. & Chiba, T., 2009 Jan 1, Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, p. 131-144 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling

Park, S., Komatsu, T., Hayashi, H., Trindade, L. S., Yamaza, H., Chiba, T. & Shimokawa, I., 2009 Oct, In : Experimental Gerontology. 44, 10, p. 646-652 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity

Chiba, T., Inoue, D., Mizuno, A., Komatsu, T., Fujita, S., Kubota, H., Luisa Tagliaro, M., Park, S., Trindade, L. S., Hayashida, T., Hayashi, H., Yamaza, H., Higami, Y. & Shimokawa, I., 2009 Mar, In : Neurobiology of Aging. 30, 3, p. 474-482 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Similar metabolic responses to calorie restriction in lean and obese Zucker rats

Chiba, T., Komatsu, T., Nakayama, M., Adachi, T., Tamashiro, Y., Hayashi, H., Yamaza, H., Higami, Y. & Shimokawa, I., 2009 Oct 15, In : Molecular and Cellular Endocrinology. 309, 1-2, p. 17-25 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2008

Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner

Park, S., Komatsu, T., Hayashi, H., Yamaza, H., Chiba, T., Higami, Y., Kuramoto, K. & Shimokawa, I., 2008 Dec, In : Age. 30, 4, p. 293-302 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

Hayashi, H., Yamaza, H., Komatsu, T., Park, S., Chiba, T., Higami, Y., Nagayasu, T. & Shimokawa, I., 2008 Sep, In : Experimental Gerontology. 43, 9, p. 827-832 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Longevity genes: Insights from calorie restriction and genetic longevity models

Shimokawa, I., Chiba, T., Yamaza, H. & Komatsu, T., 2008 Nov 30, In : Molecules and Cells. 26, 5, p. 427-435 9 p.

Research output: Contribution to journalShort survey

36 Citations (Scopus)

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8

Komatsu, T., Chiba, T., Yamaza, H., Yamashita, K., Shimada, A., Hoshiyama, Y., Henmi, T., Ohtani, H., Higami, Y., de Cabo, R., Ingram, D. K. & Shimokawa, I., 2008 Apr, In : Experimental Gerontology. 43, 4, p. 339-346 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

Chiba, T., Yamaza, H., Komatsu, T., Nakayama, M., Fujita, S., Hayashi, H., Higami, Y. & Shimokawa, I., 2008 Jun, In : Experimental Gerontology. 43, 6, p. 595-600 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2007

Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver

To, K., Yamaza, H., Komatsu, T., Hayashida, T., Hayashi, H., Toyama, H., Chiba, T., Higami, Y. & Shimokawa, I., 2007 Nov, In : Experimental Gerontology. 42, 11, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis

Chiba, T., Yao, J., Higami, Y., Shimokawa, I., Hosokawa, M. & Higuchi, K., 2007 Feb, In : Mammalian Genome. 18, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification of fasting-induced genes in the rat hypothalamus: Relationship with neuroprotection

Chiba, T., Fujita, S., Kubota, H., Inoue, D., Mizuno, A., Komatsu, T., Yamaza, H., Higami, Y. & Shimokawa, I., 2007 Nov, In : Annals of the New York Academy of Sciences. 1119, 1, p. 216-226 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: Regulation of plasma adiponectin and leptin

Yamaza, H., Komatsu, T., To, K., Toyama, H., Chiba, T., Higami, Y. & Shimokawa, I., 2007 Jan, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)

Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: Rodent longevity models for studying aging and calorie restriction

Chiba, T., Yamaza, H. & Shimokawa, I., 2007 Nov, In : Current Genomics. 8, 7, p. 423-428 6 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted

Liu, E., Lee, A. Y. L., Chiba, T., Olson, E., Sun, P. & Wu, X., 2007 Nov 19, In : Journal of Cell Biology. 179, 4, p. 643-657 15 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2006

Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle

Park, S., Komatsu, T., Hayashi, H., Yamaza, H., Chiba, T., Higami, Y., Kuramoto, K. & Shimokawa, I., 2006 Sep, In : Experimental Gerontology. 41, 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of leptin on hypothalamic gene expression in calorie-restricted rats

Komatsu, T., Chiba, T., Yamaza, H., To, K., Toyama, H., Higami, Y. & Shimokawa, I., 2006 Sep, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 61, 9, p. 890-898 9 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression

Higami, Y., Tsuchiya, T., Chiba, T., Yamaza, H., Muraoka, I., Hirose, M., Komatsu, T. & Shimokawa, I., 2006 Nov, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 61, 11, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)
2005

Acute stress response in calorie-restricted rats to lipopolysaccharide- induced inflammation

Tsuchiya, T., Higami, Y., Komatsu, T., Tanaka, K., Honda, S., Yamaza, H., Chiba, T., Ayabe, H. & Shimokawa, I., 2005 May, In : Mechanisms of Ageing and Development. 126, 5, p. 568-579 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2004

A transgenic dwarf rat model as a tool for the study of calorie restriction and aging

Yamaza, H., Komatsu, T., Chiba, T., Toyama, H., To, K., Higami, Y. & Shimokawa, I., 2004 Feb, In : Experimental Gerontology. 39, 2, p. 269-272 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes

Higami, Y., Tsuchiya, T., To, K., Chiba, T., Yamaza, H., Shiokawa, D., Tanuma, S. I. & Shimokawa, I., 2004 Jun, In : Cell and Tissue Research. 316, 3, p. 403-407 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mouse testis transcriptome reveled using serial analysis of gene expression

Yao, J., Chiba, T., Sakai, J., Hirose, K., Yamamoto, M., Hada, A., Kuramoto, K., Higuchi, K. & Mori, M., 2004 Jun, In : Mammalian Genome. 15, 6, p. 433-451 19 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control

Wu, X., Avni, D., Chiba, T., Yan, F., Zhao, Q., Lin, Y., Heng, H. & Livingston, D., 2004 Jun 1, In : Genes and Development. 18, 11, p. 1305-1316 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)
2003

Effects of caloric restriction on gene expression in the arcuate nucleus

Shimokawa, I., Fukuyama, T., Yanagihara-Outa, K., Tomita, M., Komatsu, T., Higami, Y., Tuchiya, T., Chiba, T. & Yamaza, Y., 2003 Jan 1, In : Neurobiology of Aging. 24, 1, p. 117-123 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.

Shimokawa, I., Higami, Y., Tsuchiya, T., Otani, H., Komatsu, T., Chiba, T. & Yamaza, H., 2003 Jun, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 9, p. 1108-1109 2 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
2002

Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling

Chiba, T., Yamaza, H., Higami, Y. & Shimokawa, I., 2002 Nov 15, In : Microscopy Research and Technique. 59, 4, p. 317-324 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Lifespan extension by caloric restriction: An aspect of energy metabolism

Yamaza, H., Chiba, T., Higami, Y. & Shimokawa, I., 2002 Nov 15, In : Microscopy Research and Technique. 59, 4, p. 325-330 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model

Shimokawa, I., Higami, Y., Utsuyama, M., Tuchiya, T., Komatsu, T., Chiba, T. & Yamaza, H., 2002 Jun, In : American Journal of Pathology. 160, 6, p. 2259-2265 7 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2001

Extrahepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis

Fu, L., Matsuyama, I., Chiba, T., Xing, Y., Korenaga, T., Guo, Z., Fu, X., Nakayama, J., Mori, M. & Higuchi, K., 2001 Jan 1, In : Journal of Histochemistry and Cytochemistry. 49, 6, p. 739-747 9 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)