β1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo

Yoshikuni Edagawa, Chie Yamaguchi, Hiroshi Saito, Tadahiro Takeda, Noriko Shimizu, Takao Narui, Shoji Shibata, Yoshihisa Ito

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The mechanism underlying the enhancement of long-term potentiation (LTP) induced by the systemic administration of PB-2, an α(1-3)(1-4)glucan- containing fraction extracted from the lichen Flavoparmelia baltimorensis and a putative LTP-enhancing agent, was investigated in the rat dentate gyrus in vivo. Particular attention was paid to the role of adrenaline β-receptors. An intravenous (i.v.) injection of PB-2 enhanced the induction of LTP, which was in turn inhibited by an i.v. injection of the adrenaline β1- receptor antagonist atenolol. An intracerebroventricular injection of atenolol did not affect the induction of LTP, but completely suppressed the PB-2-induced enhancement of LTP. The infusion of atenolol into the recording site attenuated the PB-2-induced facilitation of LTP. These results suggest that the adrenaline β1-receptors contribute to the enhancement of LTP induced by the systemic administration of PB-2, and that the functional β1- receptors are located both centrally and peripherally.

    Original languageEnglish
    Pages (from-to)363-368
    Number of pages6
    JournalNeuroscience Research
    Volume53
    Issue number4
    DOIs
    Publication statusPublished - 2005 Dec

    Fingerprint

    Lichens
    Glucans
    Long-Term Potentiation
    Dentate Gyrus
    Adrenergic Receptors
    Atenolol
    Epinephrine
    Intravenous Injections
    Injections

    Keywords

    • Adrenaline β-receptor
    • Dentate gyrus
    • Glucan
    • In vivo recording
    • Lichen
    • Long-term potentiation (LTP)

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    β1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo. / Edagawa, Yoshikuni; Yamaguchi, Chie; Saito, Hiroshi; Takeda, Tadahiro; Shimizu, Noriko; Narui, Takao; Shibata, Shoji; Ito, Yoshihisa.

    In: Neuroscience Research, Vol. 53, No. 4, 12.2005, p. 363-368.

    Research output: Contribution to journalArticle

    Edagawa, Yoshikuni ; Yamaguchi, Chie ; Saito, Hiroshi ; Takeda, Tadahiro ; Shimizu, Noriko ; Narui, Takao ; Shibata, Shoji ; Ito, Yoshihisa. / β1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo. In: Neuroscience Research. 2005 ; Vol. 53, No. 4. pp. 363-368.
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