2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture

Julius Adam V. Lopez, Toshihiko Nogawa, Kazuko Yoshida, Yushi Futamura, Hiroyuki Osada

Research output: Contribution to journalArticlepeer-review

Abstract

2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5'-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 µm and had no effect on the growth of Arabidopsis at 2 µm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalBioscience, biotechnology, and biochemistry
Volume86
Issue number1
DOIs
Publication statusPublished - 2021 Dec 22
Externally publishedYes

Keywords

  • antimalaria
  • Plasmodium falciparum
  • Streptomyces
  • zeatin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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