5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Yoshikuni Edagawa; Hiroshi Saito; Kazuho Abe

doi:10.1016/S0014-2999(98)00286-6

5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT₁ receptor antagonist, pindolol (10 μM), but not by the 5-HT_2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT_3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	European Journal of Pharmacology
Volume	349
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-2999(98)00286-6
Publication status	Published - 1998 May 22
Externally published	Yes

Keywords

5-HT (5-hydroxytryptamine, serotonin)
5-HT(1A) receptor
8-OH-DPAT (8-hydroxy-2-(N,N-dipropylamino)tetralin
Field potential
Long-term potentiation
Visual cortex

ASJC Scopus subject areas

Pharmacology

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10.1016/S0014-2999(98)00286-6

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title = "5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex",

abstract = "We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.",

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author = "Yoshikuni Edagawa and Hiroshi Saito and Kazuho Abe",

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AU - Edagawa, Yoshikuni

AU - Saito, Hiroshi

AU - Abe, Kazuho

PY - 1998/5/22

Y1 - 1998/5/22

N2 - We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

AB - We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

KW - 5-HT (5-hydroxytryptamine, serotonin)

KW - 5-HT(1A) receptor

KW - 8-OH-DPAT (8-hydroxy-2-(N,N-dipropylamino)tetralin

KW - Field potential

KW - Long-term potentiation

KW - Visual cortex

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5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Abstract

Keywords

ASJC Scopus subject areas

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