5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalEuropean Journal of Pharmacology
Volume349
Issue number2-3
DOIs
Publication statusPublished - 1998 May 22
Externally publishedYes

Fingerprint

8-Hydroxy-2-(di-n-propylamino)tetralin
Receptor, Serotonin, 5-HT1A
Long-Term Potentiation
Visual Cortex
Serotonin 5-HT1 Receptors
Ritanserin
Serotonin 5-HT1 Receptor Antagonists
Pindolol
Receptors, Serotonin, 5-HT3
Evoked Potentials
Perfusion
hydroxide ion

Keywords

  • 5-HT (5-hydroxytryptamine, serotonin)
  • 5-HT(1A) receptor
  • 8-OH-DPAT (8-hydroxy-2-(N,N-dipropylamino)tetralin
  • Field potential
  • Long-term potentiation
  • Visual cortex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex. / Edagawa, Yoshikuni; Saito, Hiroshi; Abe, Kazuho.

In: European Journal of Pharmacology, Vol. 349, No. 2-3, 22.05.1998, p. 221-224.

Research output: Contribution to journalArticle

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