5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe

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Abstract

We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalEuropean Journal of Pharmacology
Volume349
Issue number2-3
DOIs
Publication statusPublished - 1998 May 22
Externally publishedYes

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Keywords

  • 5-HT (5-hydroxytryptamine, serotonin)
  • 5-HT(1A) receptor
  • 8-OH-DPAT (8-hydroxy-2-(N,N-dipropylamino)tetralin
  • Field potential
  • Long-term potentiation
  • Visual cortex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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