6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone

Katsuyuki Sakai, Risa Takao, Hiroyuki Koshino, Yushi Futamura, Hiroyuki Osada, Shunji Takahashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC50 value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.

Original languageEnglish
Pages (from-to)593-595
Number of pages3
JournalJournal of Antibiotics
Volume74
Issue number9
DOIs
Publication statusPublished - 2021 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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