TY - JOUR
T1 - 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone
AU - Sakai, Katsuyuki
AU - Takao, Risa
AU - Koshino, Hiroyuki
AU - Futamura, Yushi
AU - Osada, Hiroyuki
AU - Takahashi, Shunji
N1 - Funding Information:
Acknowledgements We thank Prof. Haruo Ikeda and Prof. Hiroyasu Onaka for providing the pKU592 and pTYM19 vectors, respectively. This work was supported by JSPS KAKENHI Grant Number 20H00416 to (ST).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2021/9
Y1 - 2021/9
N2 - A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC50 value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.
AB - A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC50 value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.
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U2 - 10.1038/s41429-021-00442-1
DO - 10.1038/s41429-021-00442-1
M3 - Article
C2 - 34234285
AN - SCOPUS:85109984233
SN - 0021-8820
VL - 74
SP - 593
EP - 595
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 9
ER -