7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon

Shogo Haraguchi, Yuzo Yamamoto, Yuko Suzuki, Joon Hyung Chang, Teppei Koyama, Miku Sato, Masatoshi Mita, Hiroshi Ueda, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Salmon migrate upstream against an opposing current in their natal river. However, the molecular mechanisms that stimulate upstream migratory behavior are poorly understood. Here, we show that 7α-hydroxypregnenolone (7α-OH PREG), a newly identified neuronal modulator of locomotion, acts as a key factor for upstream migration in salmon. We first identified 7α-OH PREG and cytochrome P450 7α-hydroxylase (P450 7α), a steroidogenic enzyme producing 7α-OH PREG, in the salmon brain and then found that 7α-OH PREG synthesis in the brain increases during upstream migration. Subsequently, we demonstrated that 7α-OH PREG increases upstream migratory behavior of salmon. We further found that 7α-OH PREG acts on dopamine neurons in the magnocellular preoptic nucleus during upstream migration. Thus, 7α-OH PREG stimulates upstream migratory behavior through the dopaminergic system in salmon. These findings provide new insights into the molecular mechanisms of fish upstream migration.

    Original languageEnglish
    Article number12546
    JournalScientific Reports
    Volume5
    DOIs
    Publication statusPublished - 2015 Jul 29

    Fingerprint

    Salmon
    Locomotion
    Cholesterol 7-alpha-Hydroxylase
    Preoptic Area
    Dopaminergic Neurons
    Brain
    Mixed Function Oxygenases
    Rivers
    Fishes
    7-hydroxypregnenolone
    Enzymes

    ASJC Scopus subject areas

    • General

    Cite this

    7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon. / Haraguchi, Shogo; Yamamoto, Yuzo; Suzuki, Yuko; Chang, Joon Hyung; Koyama, Teppei; Sato, Miku; Mita, Masatoshi; Ueda, Hiroshi; Tsutsui, Kazuyoshi.

    In: Scientific Reports, Vol. 5, 12546, 29.07.2015.

    Research output: Contribution to journalArticle

    Haraguchi, Shogo ; Yamamoto, Yuzo ; Suzuki, Yuko ; Chang, Joon Hyung ; Koyama, Teppei ; Sato, Miku ; Mita, Masatoshi ; Ueda, Hiroshi ; Tsutsui, Kazuyoshi. / 7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon. In: Scientific Reports. 2015 ; Vol. 5.
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    abstract = "Salmon migrate upstream against an opposing current in their natal river. However, the molecular mechanisms that stimulate upstream migratory behavior are poorly understood. Here, we show that 7α-hydroxypregnenolone (7α-OH PREG), a newly identified neuronal modulator of locomotion, acts as a key factor for upstream migration in salmon. We first identified 7α-OH PREG and cytochrome P450 7α-hydroxylase (P450 7α), a steroidogenic enzyme producing 7α-OH PREG, in the salmon brain and then found that 7α-OH PREG synthesis in the brain increases during upstream migration. Subsequently, we demonstrated that 7α-OH PREG increases upstream migratory behavior of salmon. We further found that 7α-OH PREG acts on dopamine neurons in the magnocellular preoptic nucleus during upstream migration. Thus, 7α-OH PREG stimulates upstream migratory behavior through the dopaminergic system in salmon. These findings provide new insights into the molecular mechanisms of fish upstream migration.",
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    AU - Suzuki, Yuko

    AU - Chang, Joon Hyung

    AU - Koyama, Teppei

    AU - Sato, Miku

    AU - Mita, Masatoshi

    AU - Ueda, Hiroshi

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