7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion

Discovery, progress and prospect

Kazuyoshi Tsutsui, Shogo Haraguchi, Masahiro Matsunaga, Teppei Koyama, Jean Luc Do Rego, Hubert Vaudry

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Seasonally-breeding amphibians have served as excellent animal models to investigate the biosynthesis and biological actions of neurosteroids. Previous studies have demonstrated that the brain of amphibians possesses key steroidogenic enzymes and produces pregnenolone, a precursor of steroid hormones, and other various neurosteroids. We recently found that the brain of seasonally-breeding newts actively produces 7α-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. This novel amphibian neurosteroid acts as a neuronal modulator to stimulate locomotor activity in newts. Subsequently, the mode of action of 7α-hydroxypregnenolone has been demonstrated in the newt brain. 7α-Hydroxypregnenolone stimulates locomotor activity through activation of the dopaminergic system. To understand the functional significance of 7α-hydroxypregnenolone in the regulation of locomotor activity, diurnal and seasonal changes in synthesis of 7α-hydroxypregnenolone have also been demonstrated in the newt brain. Melatonin derived from the pineal gland and eyes regulates 7α-hydroxypregnenolone synthesis in the brain, thus inducing diurnal locomotor changes. Prolactin, an adenohypophyseal hormone, regulates 7α-hydroxypregnenolone synthesis in the brain, and also induces seasonal locomotor changes. In addition, 7α-hydroxypregnenolone mediates corticosterone action to increase locomotor activity under stress. This review summarizes the discovery, progress and prospect of 7α-hydroxypregnenolone, a new key regulator of amphibian locomotion.

    Original languageEnglish
    Pages (from-to)440-447
    Number of pages8
    JournalGeneral and Comparative Endocrinology
    Volume176
    Issue number3
    DOIs
    Publication statusPublished - 2012 May 1

    Fingerprint

    Amphibians
    Locomotion
    locomotion
    amphibians
    brain
    salamanders and newts
    Salamandridae
    Neurotransmitter Agents
    Brain
    synthesis
    pregnenolone
    pineal body
    Breeding
    breeding
    steroid hormones
    melatonin
    corticosterone
    prolactin
    Anterior Pituitary Hormones
    7-hydroxypregnenolone

    Keywords

    • 7α-Hydroxypregnenolone
    • Cytochrome P450
    • Diurnal and seasonal changes
    • Dopamine
    • Locomotor activity
    • Melatonin
    • Neurosteroids
    • Newts
    • Prolactin
    • Stress

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion : Discovery, progress and prospect. / Tsutsui, Kazuyoshi; Haraguchi, Shogo; Matsunaga, Masahiro; Koyama, Teppei; Do Rego, Jean Luc; Vaudry, Hubert.

    In: General and Comparative Endocrinology, Vol. 176, No. 3, 01.05.2012, p. 440-447.

    Research output: Contribution to journalArticle

    Tsutsui, Kazuyoshi ; Haraguchi, Shogo ; Matsunaga, Masahiro ; Koyama, Teppei ; Do Rego, Jean Luc ; Vaudry, Hubert. / 7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion : Discovery, progress and prospect. In: General and Comparative Endocrinology. 2012 ; Vol. 176, No. 3. pp. 440-447.
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