A 12-week after-school physical activity programme improves endothelial cell function in overweight and obese children

a randomised controlled study

Jong Hwan Park, Masashi Miyashita, Yoo Chan Kwon, Hyun Tae Park, Eun Hee Kim, Jin Kee Park, Ki Beam Park, Suk Ran Yoon, Jin Woong Chung, Yoshio Nakamura, Sang Kab Park

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.Methods: A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34+ (a cell surface marker on hematopoietic stem cells), CD133+ (a cell surface marker on hematopoietic progenitor cells) and CD34+/CD133+ (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.Results: Increased percentages of CD34+, CD133+ and CD34+/CD133+ cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.Trial registration: Current Controlled Trials ISRCTN19037201.

Original languageEnglish
Article number111
JournalBMC Pediatrics
Volume12
DOIs
Publication statusPublished - 2012 Jul 31

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Endothelial Cells
Exercise
Hematopoietic Stem Cells
Carotid Intima-Media Thickness
Control Groups
Pediatric Obesity
Flow Cytometry
Health
Endothelial Progenitor Cells

Keywords

  • After-school exercise programme
  • Carotid intima-media thickness
  • Endothelial cell function
  • Endothelial progenitor cells
  • Overweight/obese children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A 12-week after-school physical activity programme improves endothelial cell function in overweight and obese children : a randomised controlled study. / Park, Jong Hwan; Miyashita, Masashi; Kwon, Yoo Chan; Park, Hyun Tae; Kim, Eun Hee; Park, Jin Kee; Park, Ki Beam; Yoon, Suk Ran; Chung, Jin Woong; Nakamura, Yoshio; Park, Sang Kab.

In: BMC Pediatrics, Vol. 12, 111, 31.07.2012.

Research output: Contribution to journalArticle

Park, Jong Hwan ; Miyashita, Masashi ; Kwon, Yoo Chan ; Park, Hyun Tae ; Kim, Eun Hee ; Park, Jin Kee ; Park, Ki Beam ; Yoon, Suk Ran ; Chung, Jin Woong ; Nakamura, Yoshio ; Park, Sang Kab. / A 12-week after-school physical activity programme improves endothelial cell function in overweight and obese children : a randomised controlled study. In: BMC Pediatrics. 2012 ; Vol. 12.
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abstract = "Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.Methods: A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34+ (a cell surface marker on hematopoietic stem cells), CD133+ (a cell surface marker on hematopoietic progenitor cells) and CD34+/CD133+ (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.Results: Increased percentages of CD34+, CD133+ and CD34+/CD133+ cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.Trial registration: Current Controlled Trials ISRCTN19037201.",
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T2 - a randomised controlled study

AU - Park, Jong Hwan

AU - Miyashita, Masashi

AU - Kwon, Yoo Chan

AU - Park, Hyun Tae

AU - Kim, Eun Hee

AU - Park, Jin Kee

AU - Park, Ki Beam

AU - Yoon, Suk Ran

AU - Chung, Jin Woong

AU - Nakamura, Yoshio

AU - Park, Sang Kab

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N2 - Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.Methods: A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34+ (a cell surface marker on hematopoietic stem cells), CD133+ (a cell surface marker on hematopoietic progenitor cells) and CD34+/CD133+ (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.Results: Increased percentages of CD34+, CD133+ and CD34+/CD133+ cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.Trial registration: Current Controlled Trials ISRCTN19037201.

AB - Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.Methods: A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34+ (a cell surface marker on hematopoietic stem cells), CD133+ (a cell surface marker on hematopoietic progenitor cells) and CD34+/CD133+ (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.Results: Increased percentages of CD34+, CD133+ and CD34+/CD133+ cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.Trial registration: Current Controlled Trials ISRCTN19037201.

KW - After-school exercise programme

KW - Carotid intima-media thickness

KW - Endothelial cell function

KW - Endothelial progenitor cells

KW - Overweight/obese children

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