A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase

Roichi Itoh; Hirotoshi Echizen; Mitsuru Higuchi; Jun Oka; Kouichi Yamada

doi:10.1016/0305-0491(92)90427-S

A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase

Roichi Itoh, Hirotoshi Echizen, Mitsuru Higuchi, Jun Oka, Kouichi Yamada

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.

Original language	English
Pages (from-to)	153-159
Number of pages	7
Journal	Comparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/0305-0491(92)90427-S
Publication status	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physiology

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title = "A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase",

abstract = "1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.",

author = "Roichi Itoh and Hirotoshi Echizen and Mitsuru Higuchi and Jun Oka and Kouichi Yamada",

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T1 - A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase

AU - Itoh, Roichi

AU - Echizen, Hirotoshi

AU - Higuchi, Mitsuru

AU - Oka, Jun

AU - Yamada, Kouichi

PY - 1992

Y1 - 1992

N2 - 1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.

AB - 1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.

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