A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase

Roichi Itoh, Hirotoshi Echizen, Mitsuru Higuchi, Jun Oka, Kouichi Yamada

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume103
Issue number1
DOIs
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology

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