TY - JOUR
T1 - A comparative study on tissue distribution and metabolic adaptation of IMP-GMP 5′-nucleotidase
AU - Itoh, Roichi
AU - Echizen, Hirotoshi
AU - Higuchi, Mitsuru
AU - Oka, Jun
AU - Yamada, Kouichi
PY - 1992
Y1 - 1992
N2 - 1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.
AB - 1. 1. Activity of a cytoplasmic 5′-nucleotidase which preferentially hydrolyzes IMP and GMP (IMP-GMP 5′-nucleotidase) was determined by a specific immunochemical method in two species of birds and two species of mammals. 2. 2. The activity was markedly high in avian liver, and it increased two-fold in response to a high protein diet in chicken liver. 3. 3. In mammals, the activity was high in testis and spleen. In the rat, the activities in liver, kidney and heart extracts increased by about 30% in response to the high protein diet, while they increased three-fold in regenerating liver. 4. 4. Low activities were detected in skeletal muscles and in erythrocytes of all the species studied.
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U2 - 10.1016/0305-0491(92)90427-S
DO - 10.1016/0305-0491(92)90427-S
M3 - Article
C2 - 1333384
AN - SCOPUS:0026701617
VL - 103
SP - 153
EP - 159
JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
SN - 1096-4959
IS - 1
ER -