A comparison of gene expression profiles of rat tissues after mild and short-term calorie restrictions

Kenji Saito, Maiko Ito, Takuya Chiba, Huijuan Jia, Hisanori Kato*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Many studies have shown the beneficial effects of calorie restriction (CR) on rodents’ aging; however, the molecular mechanism explaining these beneficial effects is still not fully understood. Previously, we conducted transcriptomic analysis on rat liver with short-term and mild-to-moderate CR to elucidate its early response to such diet. Here, we expanded transcriptome analysis to muscle, adipose tissue, intestine, and brain and compared the gene expression profiles of these multiple organs and of our previous dataset. Several altered gene expressions were found, some of which known to be related to CR. Notably, the commonly regulated genes by CR include nicotinamide phosphoribosyltransferase and heat shock protein 90, which are involved in declining the aging process and thus potential therapeutic targets for aging-related diseases. The data obtained here provide information on early response markers and key mediators of the CR-induced delay in aging as well as on age-associated pathological changes in mammals.

Original languageEnglish
Article number2277
Issue number7
Publication statusPublished - 2021 Jul


  • Calorie restriction
  • Gene expression profiles
  • Nutrigenomics
  • Rat

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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