A computational fluid dynamics (CFD) study of WEB-treated aneurysms: Can CFD predict WEB “compression” during follow-up?

Jildaz Caroff, Cristian Mihalea, Valerio Da Ros, Takanobu Yagi, Marta Iacobucci, Léon Ikka, Jacques Moret, Laurent Spelle

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to “compression” of the device. Objective We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related. Methods We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB “compression” and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio. Results Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented “compression” during follow-up. Interestingly, device “compression” was statistically correlated to the CFD inflow ratio (P = 0.018), although not to aneurysm volume, aspect ratio or neck size. Conclusion The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalJournal of Neuroradiology
Volume44
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Hydrodynamics
Aneurysm
Equipment and Supplies
Middle Cerebral Artery
Angiography
Neck

Keywords

  • Aneurysms
  • Computational fluid dynamics
  • Interventional neuroradiology
  • Recurrence
  • WEB device

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

A computational fluid dynamics (CFD) study of WEB-treated aneurysms : Can CFD predict WEB “compression” during follow-up? / Caroff, Jildaz; Mihalea, Cristian; Da Ros, Valerio; Yagi, Takanobu; Iacobucci, Marta; Ikka, Léon; Moret, Jacques; Spelle, Laurent.

In: Journal of Neuroradiology, Vol. 44, No. 4, 01.07.2017, p. 262-268.

Research output: Contribution to journalArticle

Caroff, Jildaz ; Mihalea, Cristian ; Da Ros, Valerio ; Yagi, Takanobu ; Iacobucci, Marta ; Ikka, Léon ; Moret, Jacques ; Spelle, Laurent. / A computational fluid dynamics (CFD) study of WEB-treated aneurysms : Can CFD predict WEB “compression” during follow-up?. In: Journal of Neuroradiology. 2017 ; Vol. 44, No. 4. pp. 262-268.
@article{f62f4f3e0d774207be056a9f8e6db4f4,
title = "A computational fluid dynamics (CFD) study of WEB-treated aneurysms: Can CFD predict WEB “compression” during follow-up?",
abstract = "Background Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to “compression” of the device. Objective We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related. Methods We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB “compression” and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio. Results Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented “compression” during follow-up. Interestingly, device “compression” was statistically correlated to the CFD inflow ratio (P = 0.018), although not to aneurysm volume, aspect ratio or neck size. Conclusion The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon.",
keywords = "Aneurysms, Computational fluid dynamics, Interventional neuroradiology, Recurrence, WEB device",
author = "Jildaz Caroff and Cristian Mihalea and {Da Ros}, Valerio and Takanobu Yagi and Marta Iacobucci and L{\'e}on Ikka and Jacques Moret and Laurent Spelle",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.neurad.2017.03.005",
language = "English",
volume = "44",
pages = "262--268",
journal = "Journal of Neuroradiology",
issn = "0150-9861",
publisher = "Elsevier Masson",
number = "4",

}

TY - JOUR

T1 - A computational fluid dynamics (CFD) study of WEB-treated aneurysms

T2 - Can CFD predict WEB “compression” during follow-up?

AU - Caroff, Jildaz

AU - Mihalea, Cristian

AU - Da Ros, Valerio

AU - Yagi, Takanobu

AU - Iacobucci, Marta

AU - Ikka, Léon

AU - Moret, Jacques

AU - Spelle, Laurent

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to “compression” of the device. Objective We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related. Methods We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB “compression” and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio. Results Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented “compression” during follow-up. Interestingly, device “compression” was statistically correlated to the CFD inflow ratio (P = 0.018), although not to aneurysm volume, aspect ratio or neck size. Conclusion The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon.

AB - Background Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to “compression” of the device. Objective We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related. Methods We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB “compression” and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio. Results Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented “compression” during follow-up. Interestingly, device “compression” was statistically correlated to the CFD inflow ratio (P = 0.018), although not to aneurysm volume, aspect ratio or neck size. Conclusion The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon.

KW - Aneurysms

KW - Computational fluid dynamics

KW - Interventional neuroradiology

KW - Recurrence

KW - WEB device

UR - http://www.scopus.com/inward/record.url?scp=85018988258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018988258&partnerID=8YFLogxK

U2 - 10.1016/j.neurad.2017.03.005

DO - 10.1016/j.neurad.2017.03.005

M3 - Article

C2 - 28478112

AN - SCOPUS:85018988258

VL - 44

SP - 262

EP - 268

JO - Journal of Neuroradiology

JF - Journal of Neuroradiology

SN - 0150-9861

IS - 4

ER -