A concise synthetic approach to optically active taxol C-ring fragment

Masahisa Nakada, Ei Ichi Kojima, Yukitaka Iwata

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Abstract

A concise synthetic approach to an optically active taxol C-ring fragment starting from a readily available compound is described. Lewis acid promoted-cyclization of optically active epoxy trimethylsilane 7 affords the key intermediate 8 in 69% yield (at 91% conversion). Further transformation of 8 to our taxol C-ring fragment is successfully achieved in a stereoselective manner.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number3-4
DOIs
Publication statusPublished - 1998 Jan 15

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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