TY - JOUR
T1 - A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system
AU - Tamamura, Hirokazu
AU - Ishihara, Tsunehito
AU - Otaka, Akira
AU - Koide, Takaki
AU - Miyoshi, Kengo
AU - Ibuka, Toshiro
AU - Fujii, Nobutaka
PY - 1996/8/21
Y1 - 1996/8/21
N2 - Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.
AB - Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.
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U2 - 10.1039/P19960001911
DO - 10.1039/P19960001911
M3 - Article
AN - SCOPUS:33748899070
SN - 1470-4358
SP - 1911
EP - 1912
JO - Journal of the Chemical Society. Perkin Transactions 1
JF - Journal of the Chemical Society. Perkin Transactions 1
IS - 16
ER -