A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system

Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka, Nobutaka Fujii

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Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.

Original languageEnglish
Pages (from-to)1911-1912
Number of pages2
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number16
Publication statusPublished - 1996 Aug 21


ASJC Scopus subject areas

  • Chemistry(all)

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