Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.
|Number of pages||2|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|Publication status||Published - 1996 Aug 21|
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