A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system

Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka, Nobutaka Fujii

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.

Original languageEnglish
Pages (from-to)1911-1912
Number of pages2
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number16
Publication statusPublished - 1996 Aug 21
Externally publishedYes

Fingerprint

Trifluoroacetic Acid
Cystine
Dimethyl Sulfoxide
Resins
Peptides
Disulfides
trimethylsilyl chloride

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system. / Tamamura, Hirokazu; Ishihara, Tsunehito; Otaka, Akira; Koide, Takaki; Miyoshi, Kengo; Ibuka, Toshiro; Fujii, Nobutaka.

In: Journal of the Chemical Society - Perkin Transactions 1, No. 16, 21.08.1996, p. 1911-1912.

Research output: Contribution to journalArticle

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AU - Koide, Takaki

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AU - Ibuka, Toshiro

AU - Fujii, Nobutaka

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