A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Rader S. Jensen, Anil S. Gajare, Kozo Toyota, Masaaki Yoshifuji, Fumiyuki Ozawa

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    79 Citations (Scopus)


    A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

    Original languageEnglish
    Pages (from-to)8645-8647
    Number of pages3
    JournalTetrahedron Letters
    Issue number50
    Publication statusPublished - 2005 Dec 12



    • Aryl bromide
    • Catalytic cyanation
    • Low-coordinated phosphorus ligand
    • Palladium catalyst
    • Zinc cyanide

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

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