A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Rader S. Jensen; Anil S. Gajare; Kozo Toyota; Masaaki Yoshifuji; Fumiyuki Ozawa

doi:10.1016/j.tetlet.2005.10.052

A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Rader S. Jensen, Anil S. Gajare, Kozo Toyota, Masaaki Yoshifuji^*, Fumiyuki Ozawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) ₂ in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

Original language	English
Pages (from-to)	8645-8647
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2005.10.052
Publication status	Published - 2005 Dec 12

Keywords

Aryl bromide
Catalytic cyanation
Low-coordinated phosphorus ligand
Palladium catalyst
Zinc cyanide

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tetlet.2005.10.052

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title = "A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand",

abstract = "A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.",

keywords = "Aryl bromide, Catalytic cyanation, Low-coordinated phosphorus ligand, Palladium catalyst, Zinc cyanide",

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T1 - A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

AU - Jensen, Rader S.

AU - Gajare, Anil S.

AU - Toyota, Kozo

AU - Yoshifuji, Masaaki

AU - Ozawa, Fumiyuki

PY - 2005/12/12

Y1 - 2005/12/12

N2 - A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

AB - A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

KW - Aryl bromide

KW - Catalytic cyanation

KW - Low-coordinated phosphorus ligand

KW - Palladium catalyst

KW - Zinc cyanide

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DO - 10.1016/j.tetlet.2005.10.052

M3 - Article

AN - SCOPUS:27744570429

SN - 0040-4039

VL - 46

SP - 8645

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Abstract

Keywords

ASJC Scopus subject areas

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