A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Rader S. Jensen, Anil S. Gajare, Kozo Toyota, Masaaki Yoshifuji, Fumiyuki Ozawa

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Abstract

    A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

    Original languageEnglish
    Pages (from-to)8645-8647
    Number of pages3
    JournalTetrahedron Letters
    Volume46
    Issue number50
    DOIs
    Publication statusPublished - 2005 Dec 12

    Fingerprint

    Palladium
    Bromides
    Phosphorus
    Bearings (structural)
    Ligands
    Catalysts
    diphenyl
    benzonitrile
    N-methylpyrrolidone

    Keywords

    • Aryl bromide
    • Catalytic cyanation
    • Low-coordinated phosphorus ligand
    • Palladium catalyst
    • Zinc cyanide

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand. / Jensen, Rader S.; Gajare, Anil S.; Toyota, Kozo; Yoshifuji, Masaaki; Ozawa, Fumiyuki.

    In: Tetrahedron Letters, Vol. 46, No. 50, 12.12.2005, p. 8645-8647.

    Research output: Contribution to journalArticle

    Jensen, Rader S. ; Gajare, Anil S. ; Toyota, Kozo ; Yoshifuji, Masaaki ; Ozawa, Fumiyuki. / A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand. In: Tetrahedron Letters. 2005 ; Vol. 46, No. 50. pp. 8645-8647.
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    AU - Ozawa, Fumiyuki

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