A deep brain photoreceptive molecule in the toad hypothalamus

Tomoko Yoshikawa; Toshiyuki Okano; Tadashi Oishi; Yoshitaka Fukada

doi:10.1016/S0014-5793(98)00139-2

A deep brain photoreceptive molecule in the toad hypothalamus

Tomoko Yoshikawa, Toshiyuki Okano, Tadashi Oishi, Yoshitaka Fukada^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knob-like structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response.

Original language	English
Pages (from-to)	69-72
Number of pages	4
Journal	FEBS Letters
Volume	424
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(98)00139-2
Publication status	Published - 1998 Mar 6
Externally published	Yes

Keywords

Cerebrospinal fluid-contacting neuron
Hypothalamus
Photoperiodic response
Pinopsin
Toad
anterior preoptic nucleus

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(98)00139-2

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title = "A deep brain photoreceptive molecule in the toad hypothalamus",

abstract = "We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knob-like structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response.",

keywords = "Cerebrospinal fluid-contacting neuron, Hypothalamus, Photoperiodic response, Pinopsin, Toad, anterior preoptic nucleus",

author = "Tomoko Yoshikawa and Toshiyuki Okano and Tadashi Oishi and Yoshitaka Fukada",

note = "Funding Information: This work was partly supported by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports and Culture, and by the Sasagawa Scientific Research Grant from the Japan Science Society.",

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T1 - A deep brain photoreceptive molecule in the toad hypothalamus

AU - Yoshikawa, Tomoko

AU - Okano, Toshiyuki

AU - Oishi, Tadashi

AU - Fukada, Yoshitaka

N1 - Funding Information: This work was partly supported by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports and Culture, and by the Sasagawa Scientific Research Grant from the Japan Science Society.

PY - 1998/3/6

Y1 - 1998/3/6

N2 - We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knob-like structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response.

AB - We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knob-like structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response.

KW - Cerebrospinal fluid-contacting neuron

KW - Hypothalamus

KW - Photoperiodic response

KW - Pinopsin

KW - Toad

KW - anterior preoptic nucleus

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A deep brain photoreceptive molecule in the toad hypothalamus

Abstract

Keywords

ASJC Scopus subject areas

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