A deep brain photoreceptive molecule in the toad hypothalamus

Tomoko Yoshikawa, Toshiyuki Okano, Tadashi Oishi, Yoshitaka Fukada

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knob-like structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalFEBS Letters
Volume424
Issue number1-2
DOIs
Publication statusPublished - 1998 Mar 6
Externally publishedYes

Fingerprint

Anura
Hypothalamus
Brain
Knobs
Cerebrospinal fluid
Opsins
Molecules
Gene Library
Neurons
Complementary DNA
Cells
Bufonidae
Amino Acids
Preoptic Area
Antibodies
Breeding
Cerebrospinal Fluid
Vertebrates
Tail
Amino Acid Sequence

Keywords

  • anterior preoptic nucleus
  • Cerebrospinal fluid-contacting neuron
  • Hypothalamus
  • Photoperiodic response
  • Pinopsin
  • Toad

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A deep brain photoreceptive molecule in the toad hypothalamus. / Yoshikawa, Tomoko; Okano, Toshiyuki; Oishi, Tadashi; Fukada, Yoshitaka.

In: FEBS Letters, Vol. 424, No. 1-2, 06.03.1998, p. 69-72.

Research output: Contribution to journalArticle

Yoshikawa, Tomoko ; Okano, Toshiyuki ; Oishi, Tadashi ; Fukada, Yoshitaka. / A deep brain photoreceptive molecule in the toad hypothalamus. In: FEBS Letters. 1998 ; Vol. 424, No. 1-2. pp. 69-72.
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