A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Takeshi Tanoue, Satoru Morita, Damian R. Plichta, Ashwin N. Skelly, Wataru Suda, Yuki Sugiura, Seiko Narushima, Hera Vlamakis, Iori Motoo, Kayoko Sugita, Atsushi Shiota, Kozue Takeshita, Keiko Yasuma-Mitobe, Dieter Riethmacher, Tsuneyasu Kaisho, Jason M. Norman, Daniel Mucida, Makoto Suematsu, Tomonori Yaguchi, Vanni Bucci & 8 others Takashi Inoue, Yutaka Kawakami, Bernat Olle, Bruce Roberts, Masahira Hattori, Ramnik J. Xavier, Koji Atarashi, Kenya Honda

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 + dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.

Original languageEnglish
Pages (from-to)600-605
Number of pages6
JournalNature
Volume565
Issue number7741
DOIs
Publication statusPublished - 2019 Jan 31

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Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
Listeria monocytogenes
Feces
Dendritic Cells
Interferons
Intestines
Neoplasms
Inflammation
Therapeutics
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • General

Cite this

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., ... Honda, K. (2019). A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature, 565(7741), 600-605. https://doi.org/10.1038/s41586-019-0878-z

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. / Tanoue, Takeshi; Morita, Satoru; Plichta, Damian R.; Skelly, Ashwin N.; Suda, Wataru; Sugiura, Yuki; Narushima, Seiko; Vlamakis, Hera; Motoo, Iori; Sugita, Kayoko; Shiota, Atsushi; Takeshita, Kozue; Yasuma-Mitobe, Keiko; Riethmacher, Dieter; Kaisho, Tsuneyasu; Norman, Jason M.; Mucida, Daniel; Suematsu, Makoto; Yaguchi, Tomonori; Bucci, Vanni; Inoue, Takashi; Kawakami, Yutaka; Olle, Bernat; Roberts, Bruce; Hattori, Masahira; Xavier, Ramnik J.; Atarashi, Koji; Honda, Kenya.

In: Nature, Vol. 565, No. 7741, 31.01.2019, p. 600-605.

Research output: Contribution to journalArticle

Tanoue, T, Morita, S, Plichta, DR, Skelly, AN, Suda, W, Sugiura, Y, Narushima, S, Vlamakis, H, Motoo, I, Sugita, K, Shiota, A, Takeshita, K, Yasuma-Mitobe, K, Riethmacher, D, Kaisho, T, Norman, JM, Mucida, D, Suematsu, M, Yaguchi, T, Bucci, V, Inoue, T, Kawakami, Y, Olle, B, Roberts, B, Hattori, M, Xavier, RJ, Atarashi, K & Honda, K 2019, 'A defined commensal consortium elicits CD8 T cells and anti-cancer immunity', Nature, vol. 565, no. 7741, pp. 600-605. https://doi.org/10.1038/s41586-019-0878-z
Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y et al. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019 Jan 31;565(7741):600-605. https://doi.org/10.1038/s41586-019-0878-z
Tanoue, Takeshi ; Morita, Satoru ; Plichta, Damian R. ; Skelly, Ashwin N. ; Suda, Wataru ; Sugiura, Yuki ; Narushima, Seiko ; Vlamakis, Hera ; Motoo, Iori ; Sugita, Kayoko ; Shiota, Atsushi ; Takeshita, Kozue ; Yasuma-Mitobe, Keiko ; Riethmacher, Dieter ; Kaisho, Tsuneyasu ; Norman, Jason M. ; Mucida, Daniel ; Suematsu, Makoto ; Yaguchi, Tomonori ; Bucci, Vanni ; Inoue, Takashi ; Kawakami, Yutaka ; Olle, Bernat ; Roberts, Bruce ; Hattori, Masahira ; Xavier, Ramnik J. ; Atarashi, Koji ; Honda, Kenya. / A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. In: Nature. 2019 ; Vol. 565, No. 7741. pp. 600-605.
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