A design and feasibility study of reactions comprising DNA molecular machine that walks autonomously by using a restriction enzyme

Hiroyuki Sekiguchi, Ken Komiya, Daisuke Kiga, Masayuki Yamamura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this paper, we propose an autonomous molecular walking machine using DNA. This molecular machine follows a track of DNA equipped with many single-strand DNA stators arranged in a certain pattern. The molecular machine achieves autonomous walk by using a restriction enzyme as source of power. With a proposed machine we can control its moving direction and we can easily extend walking patterns in two or three dimensions. Combination of multiple legs and ssDNA stators can control the walking pattern. We designed and performed a series of feasibility study with computer simulation and molecular biology experiments.

Original languageEnglish
Pages (from-to)303-315
Number of pages13
JournalNatural Computing
Volume7
Issue number3
DOIs
Publication statusPublished - 2008 Sep
Externally publishedYes

Fingerprint

DNA
Enzymes
Stators
Molecular biology
Computer simulation
Experiments

Keywords

  • DNA computing
  • DNA molecular machine
  • DNA walker
  • DNA walking machine
  • Nanorobotics
  • Nanotechnology

ASJC Scopus subject areas

  • Computer Science(all)

Cite this

A design and feasibility study of reactions comprising DNA molecular machine that walks autonomously by using a restriction enzyme. / Sekiguchi, Hiroyuki; Komiya, Ken; Kiga, Daisuke; Yamamura, Masayuki.

In: Natural Computing, Vol. 7, No. 3, 09.2008, p. 303-315.

Research output: Contribution to journalArticle

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