A design for the control of apoptosis in genetically modified Saccharomyces cerevisiae

Nao Nishida, Misa Noguchi, Kouichi Kuroda, Mitsuyoshi Ueda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We have engineered a system that holds potential for use as a safety switch in genetically modified yeasts. Human apoptotic factor BAX (no homolog in yeast), under the control of the FBP1 (gluconeogenesis enzyme) promoter, was conditionally expressed to induce yeast cell apoptosis after glucose depletion. Such systems might prove useful for the safe use of genetically modified organisms.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume78
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Apoptosis
  • Bax
  • Genetically modified organism (GMO)
  • Gluconeogenesis
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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