A diagnostic imaging system for cancer localization using an excimer dye laser

H. Kato, K. Aizawa, K. Nishimiya, H. Okitsu, C. Konaka, N. Kawate, K. Yoneyama, H. Shinohara, K. Kinoshita, M. Noguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Hematoporphyrin derivative has an affinity for malignant tissue and emits a red fluorescence when exposed to excitatory light. Therefore it is theoretically possible to make a diagnosis of cancer localization by observation of this fluorescence. The authors have been developing a new imaging system for cancer diagnosis using an excimer-dye laser. The excimer pulse has a 308 nm ultraviolet beam emitted by XeCl. Simplification and accuracy of the fluorescence diagnostic procedure was achieved by utilizing the nature of the pulse and a polychrometer. The diagnostic system permits endoscopic examination under ordinary observation light. Investigations have been performed in animal tumor models including FM-mouse (breast cancer) and beagle dog (esophageal cancer). Tumor tissue showed a distinct fluorescence, but no fluorescence could be observed in normal tissue, 72 hours after hematoporphyrin derivative administration.

Original languageEnglish
Pages (from-to)1647-1652
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number4 Pt 2
Publication statusPublished - 1986 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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