A diagnostic imaging system for cancer localization using an excimer dye laser

H. Kato*, K. Aizawa, K. Nishimiya, H. Okitsu, C. Konaka, N. Kawate, K. Yoneyama, H. Shinohara, K. Kinoshita, M. Noguchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Hematoporphyrin derivative has an affinity for malignant tissue and emits a red fluorescence when exposed to excitatory light. Therefore it is theoretically possible to make a diagnosis of cancer localization by observation of this fluorescence. The authors have been developing a new imaging system for cancer diagnosis using an excimer-dye laser. The excimer pulse has a 308 nm ultraviolet beam emitted by XeCl. Simplification and accuracy of the fluorescence diagnostic procedure was achieved by utilizing the nature of the pulse and a polychrometer. The diagnostic system permits endoscopic examination under ordinary observation light. Investigations have been performed in animal tumor models including FM-mouse (breast cancer) and beagle dog (esophageal cancer). Tumor tissue showed a distinct fluorescence, but no fluorescence could be observed in normal tissue, 72 hours after hematoporphyrin derivative administration.

Original languageEnglish
Pages (from-to)1647-1652
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume13
Issue number4 Pt 2
Publication statusPublished - 1986 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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