Abstract
Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl2/P{OCH(CF 3)2}3/Ag2CO3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 8946-8949 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 49 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 2010 Nov 15 |
Keywords
- C - C coupling
- homogeneous catalysis
- palladium
- regioselectivity
- thiophenes
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Ueda, K., Yanagisawa, S., Yamaguchi, J., & Itami, K. (2010). A general catalyst for the β-selective C - H bond arylation of thiophenes with iodoarenes. Angewandte Chemie - International Edition, 49(47), 8946-8949. https://doi.org/10.1002/anie.201005082