A general catalyst for the β-selective C - H bond arylation of thiophenes with iodoarenes

Kirika Ueda, Shuichi Yanagisawa, Junichiro Yamaguchi, Kenichiro Itami

Research output: Contribution to journalArticle

188 Citations (Scopus)


Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl2/P{OCH(CF 3)2}3/Ag2CO3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.

Original languageEnglish
Pages (from-to)8946-8949
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number47
Publication statusPublished - 2010 Nov 15



  • C - C coupling
  • homogeneous catalysis
  • palladium
  • regioselectivity
  • thiophenes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this