Abstract
Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl 2/P{OCH(CF 3) 2} 3/Ag 2CO 3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 8946-8949 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 49 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 2010 Nov 15 |
| Externally published | Yes |
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Keywords
- C - C coupling
- homogeneous catalysis
- palladium
- regioselectivity
- thiophenes
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
A general catalyst for the β-selective C - H bond arylation of thiophenes with iodoarenes. / Ueda, Kirika; Yanagisawa, Shuichi; Yamaguchi, Junichiro; Itami, Kenichiro.
In: Angewandte Chemie - International Edition, Vol. 49, No. 47, 15.11.2010, p. 8946-8949.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A general catalyst for the β-selective C - H bond arylation of thiophenes with iodoarenes
AU - Ueda, Kirika
AU - Yanagisawa, Shuichi
AU - Yamaguchi, Junichiro
AU - Itami, Kenichiro
PY - 2010/11/15
Y1 - 2010/11/15
N2 - Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl 2/P{OCH(CF 3) 2} 3/Ag 2CO 3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.
AB - Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl 2/P{OCH(CF 3) 2} 3/Ag 2CO 3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.
KW - C - C coupling
KW - homogeneous catalysis
KW - palladium
KW - regioselectivity
KW - thiophenes
UR - http://www.scopus.com/inward/record.url?scp=78449231481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78449231481&partnerID=8YFLogxK
U2 - 10.1002/anie.201005082
DO - 10.1002/anie.201005082
M3 - Article
C2 - 20936614
AN - SCOPUS:78449231481
VL - 49
SP - 8946
EP - 8949
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 47
ER -