A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction

Takuya Chiba, Yukari Tamashiro, Daeui Park, Tatsuya Kusudo, Ryoko Fujie, Toshimitsu Komatsu, Sang Eun Kim, Seongjoon Park, Hiroko Hayashi, Ryoichi Mori, Hitoshi Yamashita, Hae Young Chung, Isao Shimokawa

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy.

    Original languageEnglish
    Article number4517
    JournalScientific Reports
    Volume4
    DOIs
    Publication statusPublished - 2014 Mar 31

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    Neuropeptide Y
    Neuropeptides
    Physiological Adaptation
    Neoplasms
    Physiological Phenomena
    Adipokines
    Essential Genes
    Somatomedins
    Corticosterone
    Mammals
    Oxidative Stress
    Fatty Acids
    Insulin

    ASJC Scopus subject areas

    • General

    Cite this

    A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction. / Chiba, Takuya; Tamashiro, Yukari; Park, Daeui; Kusudo, Tatsuya; Fujie, Ryoko; Komatsu, Toshimitsu; Kim, Sang Eun; Park, Seongjoon; Hayashi, Hiroko; Mori, Ryoichi; Yamashita, Hitoshi; Chung, Hae Young; Shimokawa, Isao.

    In: Scientific Reports, Vol. 4, 4517, 31.03.2014.

    Research output: Contribution to journalArticle

    Chiba, T, Tamashiro, Y, Park, D, Kusudo, T, Fujie, R, Komatsu, T, Kim, SE, Park, S, Hayashi, H, Mori, R, Yamashita, H, Chung, HY & Shimokawa, I 2014, 'A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction', Scientific Reports, vol. 4, 4517. https://doi.org/10.1038/srep04517
    Chiba, Takuya ; Tamashiro, Yukari ; Park, Daeui ; Kusudo, Tatsuya ; Fujie, Ryoko ; Komatsu, Toshimitsu ; Kim, Sang Eun ; Park, Seongjoon ; Hayashi, Hiroko ; Mori, Ryoichi ; Yamashita, Hitoshi ; Chung, Hae Young ; Shimokawa, Isao. / A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction. In: Scientific Reports. 2014 ; Vol. 4.
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    abstract = "Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30{\%} DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy.",
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    AU - Fujie, Ryoko

    AU - Komatsu, Toshimitsu

    AU - Kim, Sang Eun

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    AU - Mori, Ryoichi

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