A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism

Rei Kadota, Kazuma Sugita, Kenko Uchida, Hitoshi Yamada, Masashi Yamashita, Hidenori Kimura

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.

    Original languageEnglish
    Pages (from-to)213-223
    Number of pages11
    JournalJournal of Theoretical Biology
    Volume456
    DOIs
    Publication statusPublished - 2018 Nov 7

    Keywords

    • Brain-centered glucoregulatory system
    • Endogenous glucose production
    • Hypoglycemia
    • Insulin
    • Insulin sensitivity

    ASJC Scopus subject areas

    • Statistics and Probability
    • Modelling and Simulation
    • Biochemistry, Genetics and Molecular Biology(all)
    • Immunology and Microbiology(all)
    • Agricultural and Biological Sciences(all)
    • Applied Mathematics

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