A neuroprotective effect of adenosine A1-receptor agonists on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices

Keiko Tominaga, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of adenosine (A) receptor agonists on ischemia-induced impairment of 2-deoxyglucose (2-DG) uptake by rat hippocampal slices was evaluated. Hippocampal slices were exposed to 20-min hypoxia + hypoglycemia (ischemia) and then returned to oxygenated and glucose-containing Krebs-Ringer solution for 6 h. Ischemia reduced 2-DG uptake in the hippocampal slices. The ischemia-induced reduction in 2-DG uptake was attenuated by pretreatment with A1 receptor agonists but not with A2 receptor agonists. 8-Phenyltheophylline, an A1 receptor antagonist, ex the ischemia-induced decrease. The A1 receptor agonist-induced neuroprotective effect was blocked by co-treatment with 8-phenyltheophylline. The present study suggests that the A1 receptor-mediated function has a protective role in ischemia-induced decreases in glucose metabolism in hippocam slices.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalNeuroscience Letters
Volume145
Issue number1
DOIs
Publication statusPublished - 1992 Sep 28
Externally publishedYes

Keywords

  • 2-Deoxyglucose
  • Adenosine
  • Hippocampus
  • In vitro
  • Ischemia
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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