A neuroprotective effect of histamine H1 receptor antagonist on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices

Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of histamine (HA) receptor antagonists on hypoxia + hypoglycemia (ischemia)-induced impairment of 2-deoxyglucose (2-DG) uptake by rat hippocampal slices was evaluated. Hippocampal slices were exposed to 20-min ischemia and then returned to oxygenated and glucose-containing Krebs-Ringer solution for 6 h. Ischemia reduced 2-DG uptake in the hippocampal slices. The ischemia-induced reduction in 2-DG uptake was attenuated by pretreatment with H1 receptor antagonist but not with H2 receptor antagonist. Treatment with HA exacerbated the ischemia-induced decrease. The H1 receptor antagonist-induced neuroprotective effect was blocked by co-treatment with HA. The present study suggests that the blockade of H1 receptor-mediated function has a protective role in ischemia-induced decreases in glucose metabolism in hippocampal slices.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalNeuroscience Letters
Volume151
Issue number2
DOIs
Publication statusPublished - 1993 Mar 19
Externally publishedYes

Keywords

  • 2-Deoxyglucose
  • Antihistamine drug
  • Hippocampus
  • Histamine
  • In vitro
  • Ischemia
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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