A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa

Takahiro Yamashita, Youichi Nakao, Shigeki Matsunaga, Tsutomu Oikawa, Yukimitsu Imahara, Nobuhiro Fusetani

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.

    Original languageEnglish
    Pages (from-to)2181-2184
    Number of pages4
    JournalBioorganic and Medicinal Chemistry
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - 2009 Mar 15

    Fingerprint

    Oxylipins
    Anthozoa
    Spectrum analysis
    Degradation
    Acids

    Keywords

    • Angiogenesis inhibitor
    • Marine natural products
    • Oxylipin
    • Tube formation

    ASJC Scopus subject areas

    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry
    • Biochemistry
    • Medicine(all)

    Cite this

    A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa. / Yamashita, Takahiro; Nakao, Youichi; Matsunaga, Shigeki; Oikawa, Tsutomu; Imahara, Yukimitsu; Fusetani, Nobuhiro.

    In: Bioorganic and Medicinal Chemistry, Vol. 17, No. 6, 15.03.2009, p. 2181-2184.

    Research output: Contribution to journalArticle

    Yamashita, T, Nakao, Y, Matsunaga, S, Oikawa, T, Imahara, Y & Fusetani, N 2009, 'A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa', Bioorganic and Medicinal Chemistry, vol. 17, no. 6, pp. 2181-2184. https://doi.org/10.1016/j.bmc.2008.10.083
    Yamashita, Takahiro ; Nakao, Youichi ; Matsunaga, Shigeki ; Oikawa, Tsutomu ; Imahara, Yukimitsu ; Fusetani, Nobuhiro. / A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa. In: Bioorganic and Medicinal Chemistry. 2009 ; Vol. 17, No. 6. pp. 2181-2184.
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