A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa

Takahiro Yamashita, Youichi Nakao, Shigeki Matsunaga, Tsutomu Oikawa, Yukimitsu Imahara, Nobuhiro Fusetani

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    11 Citations (Scopus)

    Abstract

    A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.

    Original languageEnglish
    Pages (from-to)2181-2184
    Number of pages4
    JournalBioorganic and Medicinal Chemistry
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - 2009 Mar 15

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    Keywords

    • Angiogenesis inhibitor
    • Marine natural products
    • Oxylipin
    • Tube formation

    ASJC Scopus subject areas

    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry
    • Biochemistry
    • Medicine(all)

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