A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa

Takahiro Yamashita; Yoichi Nakao; Shigeki Matsunaga; Tsutomu Oikawa; Yukimitsu Imahara; Nobuhiro Fusetani

doi:10.1016/j.bmc.2008.10.083

A new antiangiogenic C₂₄ oxylipin from the soft coral Sinularia numerosa

Takahiro Yamashita, Yoichi Nakao^*, Shigeki Matsunaga, Tsutomu Oikawa, Yukimitsu Imahara, Nobuhiro Fusetani

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.

Original language	English
Pages (from-to)	2181-2184
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.bmc.2008.10.083
Publication status	Published - 2009 Mar 15

Keywords

Angiogenesis inhibitor
Marine natural products
Oxylipin
Tube formation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2008.10.083

Cite this

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title = "A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa",

abstract = "A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.",

keywords = "Angiogenesis inhibitor, Marine natural products, Oxylipin, Tube formation",

author = "Takahiro Yamashita and Yoichi Nakao and Shigeki Matsunaga and Tsutomu Oikawa and Yukimitsu Imahara and Nobuhiro Fusetani",

note = "Funding Information: We are indebted to the crew of R/V Toyoshio-maru of Hiroshima University for assistance in collection of the samples. This work was partly supported by Waseda University Grant for Special Research Projects, Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (#19310138).",

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AU - Yamashita, Takahiro

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Oikawa, Tsutomu

AU - Imahara, Yukimitsu

AU - Fusetani, Nobuhiro

N1 - Funding Information: We are indebted to the crew of R/V Toyoshio-maru of Hiroshima University for assistance in collection of the samples. This work was partly supported by Waseda University Grant for Special Research Projects, Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (#19310138).

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