A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa

Takahiro Yamashita, Yoichi Nakao, Shigeki Matsunaga, Tsutomu Oikawa, Yukimitsu Imahara, Nobuhiro Fusetani

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.

Original languageEnglish
Pages (from-to)2181-2184
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number6
DOIs
Publication statusPublished - 2009 Mar 15

Keywords

  • Angiogenesis inhibitor
  • Marine natural products
  • Oxylipin
  • Tube formation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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