A new asymmetric total synthesis of enantiopure (-)-malyngolide

Hidetoshi Miyamoto, Mitsuhiro Iwamoto, Masahisa Nakada

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A new asymmetric total synthesis of (-)-malyngolide is described. This synthesis is based on the originally developed catalytic asymmetric IMCP reaction; that is, α-diazo-β-keto sulfone (13) was successfully converted to cyclopropane (12) in 92% yield with excellent enantioselectivity (97% ee), and cyclopropane (12) was successfully converted to (-)-malyngolide.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalHeterocycles
Volume66
Issue number1
DOIs
Publication statusPublished - 2005 Dec 31

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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