A new asymmetric total synthesis of enantiopure (-)-malyngolide

Hidetoshi Miyamoto, Mitsuhiro Iwamoto, Masahisa Nakada

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    A new asymmetric total synthesis of (-)-malyngolide is described. This synthesis is based on the originally developed catalytic asymmetric IMCP reaction; that is, α-diazo-β-keto sulfone (13) was successfully converted to cyclopropane (12) in 92% yield with excellent enantioselectivity (97% ee), and cyclopropane (12) was successfully converted to (-)-malyngolide.

    Original languageEnglish
    Pages (from-to)61-68
    Number of pages8
    JournalHeterocycles
    Volume66
    Issue number1
    DOIs
    Publication statusPublished - 2005 Dec 31

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    Sulfones
    Enantioselectivity
    cyclopropane
    malyngolide

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    A new asymmetric total synthesis of enantiopure (-)-malyngolide. / Miyamoto, Hidetoshi; Iwamoto, Mitsuhiro; Nakada, Masahisa.

    In: Heterocycles, Vol. 66, No. 1, 31.12.2005, p. 61-68.

    Research output: Contribution to journalArticle

    Miyamoto, Hidetoshi ; Iwamoto, Mitsuhiro ; Nakada, Masahisa. / A new asymmetric total synthesis of enantiopure (-)-malyngolide. In: Heterocycles. 2005 ; Vol. 66, No. 1. pp. 61-68.
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