A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects

Kazuyoshi Tsutsui, E. Saigoh, H. Yin, T. Ubuka, V. S. Chowdhury, T. Osugi, K. Ukena, P. J. Sharp, J. C. Wingfield, G. E. Bentley

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    In vertebrates, the neuropeptide control of gonadotrophin secretion is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotrophin-releasing hormone (GnRH). Gonadal sex steroids and inhibin inhibit gonadotrophin secretion via feedback from the gonads, but a hypothalamic neuropeptide inhibiting gonadotrophin secretion was, until recently, unknown in vertebrates. In 2000, we discovered a novel hypothalamic dodecapeptide that directly inhibits gonadotrophin release in quail and termed it gonadotrophin-inhibitory hormone (GnIH). GnIH acts on the pituitary and GnRH neurones in the hypothalamus via a novel G-protein-coupled receptor for GnIH to inhibit gonadal development and maintenance by decreasing gonadotrophin release and synthesis. The pineal hormone melatonin is a key factor controlling GnIH neural function. GnIH occurs in the hypothalamus of several avian species and is considered to be a new key neurohormone inhibiting avian reproduction. Thus, the discovery of GnIH provides novel directions to investigate neuropeptide regulation of reproduction. This review summarises the discovery, progress and prospects of GnIH, a new key neurohormone controlling reproduction.

    Original languageEnglish
    Pages (from-to)271-275
    Number of pages5
    JournalJournal of Neuroendocrinology
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Gonadotropins
    Birds
    Reproduction
    Neurotransmitter Agents
    Hormones
    Neuropeptides
    Gonadotropin-Releasing Hormone
    Hypothalamus
    Vertebrates
    Pituitary Gonadotropins
    Inhibins
    Quail
    Gonads
    Melatonin
    G-Protein-Coupled Receptors
    Steroids
    Maintenance
    Neurons

    Keywords

    • Gonadotrophin-inhibitory hormone (GnIH)
    • Gonadotrophin-releasing hormone (GnRH)
    • Gonadotrophins
    • Hypothalamus
    • Neuropeptides
    • Pituitary
    • Reproduction

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

    Cite this

    A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds : Discovery, progress and prospects. / Tsutsui, Kazuyoshi; Saigoh, E.; Yin, H.; Ubuka, T.; Chowdhury, V. S.; Osugi, T.; Ukena, K.; Sharp, P. J.; Wingfield, J. C.; Bentley, G. E.

    In: Journal of Neuroendocrinology, Vol. 21, No. 4, 2009, p. 271-275.

    Research output: Contribution to journalArticle

    Tsutsui, K, Saigoh, E, Yin, H, Ubuka, T, Chowdhury, VS, Osugi, T, Ukena, K, Sharp, PJ, Wingfield, JC & Bentley, GE 2009, 'A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects', Journal of Neuroendocrinology, vol. 21, no. 4, pp. 271-275. https://doi.org/10.1111/j.1365-2826.2009.01829.x
    Tsutsui, Kazuyoshi ; Saigoh, E. ; Yin, H. ; Ubuka, T. ; Chowdhury, V. S. ; Osugi, T. ; Ukena, K. ; Sharp, P. J. ; Wingfield, J. C. ; Bentley, G. E. / A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds : Discovery, progress and prospects. In: Journal of Neuroendocrinology. 2009 ; Vol. 21, No. 4. pp. 271-275.
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