A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects

Kazuyoshi Tsutsui, E. Saigoh, H. Yin, T. Ubuka, V. S. Chowdhury, T. Osugi, K. Ukena, P. J. Sharp, J. C. Wingfield, G. E. Bentley

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    In vertebrates, the neuropeptide control of gonadotrophin secretion is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotrophin-releasing hormone (GnRH). Gonadal sex steroids and inhibin inhibit gonadotrophin secretion via feedback from the gonads, but a hypothalamic neuropeptide inhibiting gonadotrophin secretion was, until recently, unknown in vertebrates. In 2000, we discovered a novel hypothalamic dodecapeptide that directly inhibits gonadotrophin release in quail and termed it gonadotrophin-inhibitory hormone (GnIH). GnIH acts on the pituitary and GnRH neurones in the hypothalamus via a novel G-protein-coupled receptor for GnIH to inhibit gonadal development and maintenance by decreasing gonadotrophin release and synthesis. The pineal hormone melatonin is a key factor controlling GnIH neural function. GnIH occurs in the hypothalamus of several avian species and is considered to be a new key neurohormone inhibiting avian reproduction. Thus, the discovery of GnIH provides novel directions to investigate neuropeptide regulation of reproduction. This review summarises the discovery, progress and prospects of GnIH, a new key neurohormone controlling reproduction.

    Original languageEnglish
    Pages (from-to)271-275
    Number of pages5
    JournalJournal of Neuroendocrinology
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Gonadotrophin-inhibitory hormone (GnIH)
    • Gonadotrophin-releasing hormone (GnRH)
    • Gonadotrophins
    • Hypothalamus
    • Neuropeptides
    • Pituitary
    • Reproduction

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Endocrine and Autonomic Systems
    • Cellular and Molecular Neuroscience

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  • Cite this

    Tsutsui, K., Saigoh, E., Yin, H., Ubuka, T., Chowdhury, V. S., Osugi, T., Ukena, K., Sharp, P. J., Wingfield, J. C., & Bentley, G. E. (2009). A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects. Journal of Neuroendocrinology, 21(4), 271-275. https://doi.org/10.1111/j.1365-2826.2009.01829.x