A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening

Mira Syahfriena Amir Rawa, Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takemichi Nakamura, Habibah A. Wahab, Hiroyuki Osada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A new peptaibol, RK-026A (1) was isolated from a fungus, Trichoderma sp. RK10-F026, along with atroviridin B (2), alamethicin II (3), and polysporin B (4) as a cytotoxic compound, which was selected by principal component analysis of the MS data from 5 different culture conditions. The structure of 1 was determined as a new atroviridin B derivative containing Glu at the 18th residue instead of Gln by NMR and HR-MS analyses including the investigation of detailed MS/MS fragmentations. 1 showed cytotoxicity toward K562 leukemia cells at an IC50 value of 4.1 mm.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume85
Issue number1
DOIs
Publication statusPublished - 2021 Jan 1
Externally publishedYes

Keywords

  • cytotoxicity
  • fungi
  • K562
  • natural product
  • peptaibols

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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