TY - JOUR
T1 - A New Smart 2-Min Mobile Alerting Method for Mild Cognitive Impairment Due to Alzheimer’s Disease in the Community
AU - Wang, Yujia
AU - Chen, Tong
AU - Wang, Chen
AU - Ogihara, Atsushi
AU - Ma, Xiaowen
AU - Huang, Shouqiang
AU - Zhou, Siyu
AU - Li, Shuwu
AU - Liu, Jiakang
AU - Li, Kai
N1 - Funding Information:
This research is supported by the “Integrated equipment package for individualized intelligent rehabilitation diagnosis and treatment of traditional Chinese medical encephalopathy at home—Take insomnia and epilepsy as an example based on traditional Chinese medical intelligent syndrome differentiation for treatment” which is Key R&D Program (2021C03116) of Science and Technology Department of Zhejiang Province, “Research and development of early-stage multimodal fusion early warning system and new non-invasive neuroregulatory techniques for Alzheimer’s disease” which is Key R&D Program (2022C03064) of Science and Technology Department of Zhejiang Province and “A Full Cycle Intelligent Rehabilitation System for Future TCM Multimodal Perception Enhanced Diagnosis and Integrated Treatment of Medicine and Medical Equipment for Alzheimer’s Disease” which is a scientific research project (2021JKZDZC04) of Zhejiang Chinese Medical University.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - The early identification of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD), in an early stage of AD can expand the AD warning window. We propose a new capability index evaluating the spatial execution process (SEP), which can dynamically evaluate the execution process in the space navigation task. The hypothesis is proposed that there are neurobehavioral differences between normal cognitive (NC) elderly and AD patients with MCI reflected in digital biomarkers captured during SEP. According to this, we designed a new smart 2-min mobile alerting method for MCI due to AD, for community screening. Two digital biomarkers, total mission execution distance ((Formula presented.)) and execution distance above the transverse obstacle ((Formula presented.)), were selected by step-up regression analysis. For the participants with more than 9 years of education, the alerting efficiency of the combination of the two digital biomarkers for MCI due to AD could reach 0.83. This method has the advantages of fast speed, high alerting efficiency, low cost and high intelligence and thus has a high application value for community screening in developing countries. It also provides a new intelligent alerting approach based on the human–computer interaction (HCI) paradigm for MCI due to AD in community screening.
AB - The early identification of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD), in an early stage of AD can expand the AD warning window. We propose a new capability index evaluating the spatial execution process (SEP), which can dynamically evaluate the execution process in the space navigation task. The hypothesis is proposed that there are neurobehavioral differences between normal cognitive (NC) elderly and AD patients with MCI reflected in digital biomarkers captured during SEP. According to this, we designed a new smart 2-min mobile alerting method for MCI due to AD, for community screening. Two digital biomarkers, total mission execution distance ((Formula presented.)) and execution distance above the transverse obstacle ((Formula presented.)), were selected by step-up regression analysis. For the participants with more than 9 years of education, the alerting efficiency of the combination of the two digital biomarkers for MCI due to AD could reach 0.83. This method has the advantages of fast speed, high alerting efficiency, low cost and high intelligence and thus has a high application value for community screening in developing countries. It also provides a new intelligent alerting approach based on the human–computer interaction (HCI) paradigm for MCI due to AD in community screening.
KW - alerting in the community
KW - digital biomarkers
KW - mild cognitive impairment due to Alzheimer’s disease
KW - spatial execution process
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U2 - 10.3390/brainsci13020244
DO - 10.3390/brainsci13020244
M3 - Article
AN - SCOPUS:85148889564
SN - 2076-3425
VL - 13
JO - Brain Sciences
JF - Brain Sciences
IS - 2
M1 - 244
ER -
