A novel function for nucleoside diphosphate kinase in drosophila

Hiroko Inoue, Masami Takahashi, Akira Oomori, Mariko Sekiguchi, Tohru Yoshioka

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    Abstract

    Nucleoside diphosphate (NDP) kinase is an enzyme that transfers the γ-phosphate of nucleoside triphosphates to nucleoside diphosphates. Besides this well-defined role, recent evidence suggests that NDP kinase may be implicated in a wide variety of essential cellular processes. In this paper, we showed that the NDP kinase of Drosophila exhibited protein kinase activity as well as autophosporylation. Ovalbumin was phosphorylated with guanosine 5'-(3-O-thio)triphosphate (GTPγS) or ATP. Protein kinase activity was not detected in NDP kinase mutant, abnormal wing discs (awd). These results suggest that this activity could be one of the functions of NDP kinase essential for normal fly development, since awd gene is lethal.

    Original languageEnglish
    Pages (from-to)887-892
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume218
    Issue number3
    DOIs
    Publication statusPublished - 1996 Jan 26

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    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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