A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

Masahiro Ogata, Jun Ya Ueda, Midori Hoshi, Junko Hashimoto, Takuji Nakashima, Kozue Anzai, Motoki Takagi, Kazuo Shin-Ya

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number10
DOIs
Publication statusPublished - 2007 Oct
Externally publishedYes

Keywords

  • Dichotomomyces cejpii
  • Indole-diterpene
  • JBIR-03
  • MRSA
  • Valsa ceratosperma

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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