A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

Masahiro Ogata; Jun Ya Ueda; Midori Hoshi; Junko Hashimoto; Takuji Nakashima; Kozue Anzai; Motoki Takagi; Kazuo Shin-Ya

doi:10.1038/ja.2007.83

A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

Masahiro Ogata, Jun Ya Ueda, Midori Hoshi, Junko Hashimoto, Takuji Nakashima, Kozue Anzai, Motoki Takagi^*, Kazuo Shin-Ya

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

Original language	English
Pages (from-to)	645-648
Number of pages	4
Journal	Journal of Antibiotics
Volume	60
Issue number	10
DOIs	https://doi.org/10.1038/ja.2007.83
Publication status	Published - 2007 Oct
Externally published	Yes

Keywords

Dichotomomyces cejpii
Indole-diterpene
JBIR-03
MRSA
Valsa ceratosperma

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ja.2007.83

Cite this

@article{ed87af8132194e17aa7fc306da1df71e,

title = "A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559",

abstract = "A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.",

keywords = "Dichotomomyces cejpii, Indole-diterpene, JBIR-03, MRSA, Valsa ceratosperma",

author = "Masahiro Ogata and Ueda, {Jun Ya} and Midori Hoshi and Junko Hashimoto and Takuji Nakashima and Kozue Anzai and Motoki Takagi and Kazuo Shin-Ya",

note = "Funding Information: Acknowledgement This work was supported by a grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.",

year = "2007",

month = oct,

doi = "10.1038/ja.2007.83",

language = "English",

volume = "60",

pages = "645--648",

journal = "Journal of Antibiotics",

issn = "0021-8820",

publisher = "Japan Antibiotics Research Association",

number = "10",

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T1 - A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

AU - Ogata, Masahiro

AU - Ueda, Jun Ya

AU - Hoshi, Midori

AU - Hashimoto, Junko

AU - Nakashima, Takuji

AU - Anzai, Kozue

AU - Takagi, Motoki

AU - Shin-Ya, Kazuo

N1 - Funding Information: Acknowledgement This work was supported by a grant from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.

PY - 2007/10

Y1 - 2007/10

N2 - A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

AB - A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

KW - Dichotomomyces cejpii

KW - Indole-diterpene

KW - JBIR-03

KW - MRSA

KW - Valsa ceratosperma

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DO - 10.1038/ja.2007.83

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JF - Journal of Antibiotics

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A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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