A novel L-amino acid ligase is encoded by a gene in the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae pv. phaseolicola 1448A

Toshinobu Arai, Kuniki Kino

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPP_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various heterodipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.

Original languageEnglish
Pages (from-to)3048-3050
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number11
DOIs
Publication statusPublished - 2008 Dec 1

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Keywords

  • L-amino acid ligase
  • Peptide synthesis
  • Phaseolotoxin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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