A novel L-amino acid ligase is encoded by a gene in the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae pv. phaseolicola 1448A

Toshinobu Arai, Kuniki Kino

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPP_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various heterodipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.

    Original languageEnglish
    Pages (from-to)3048-3050
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume72
    Issue number11
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Pseudomonas syringae
    Ligases
    Multigene Family
    Homoarginine
    Genes
    Amino Acids
    Basic Amino Acids
    Scaffolds
    Adenosine Triphosphate
    Proteins
    phaseolotoxin

    Keywords

    • L-amino acid ligase
    • Peptide synthesis
    • Phaseolotoxin

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry
    • Molecular Biology
    • Applied Microbiology and Biotechnology
    • Analytical Chemistry
    • Organic Chemistry

    Cite this

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    abstract = "In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPP_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various heterodipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.",
    keywords = "L-amino acid ligase, Peptide synthesis, Phaseolotoxin",
    author = "Toshinobu Arai and Kuniki Kino",
    year = "2008",
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    journal = "Bioscience, Biotechnology and Biochemistry",
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    T1 - A novel L-amino acid ligase is encoded by a gene in the phaseolotoxin biosynthetic gene cluster from Pseudomonas syringae pv. phaseolicola 1448A

    AU - Arai, Toshinobu

    AU - Kino, Kuniki

    PY - 2008

    Y1 - 2008

    N2 - In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPP_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various heterodipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.

    AB - In the phaseolotoxin biosynthetic gene cluster of Pseudomonas syringae pv. phaseolicola 1448A, the PSPP_4299 gene encodes a novel L-amino acid ligase. The PSPPH_4299 protein synthesized various heterodipeptides containing basic amino acids in an ATP-dependent manner, and also synthesized alanyl-homoarginine, part of the phaseolotoxin scaffold.

    KW - L-amino acid ligase

    KW - Peptide synthesis

    KW - Phaseolotoxin

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    JF - Bioscience, Biotechnology and Biochemistry

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