A novel mouse monoclonal antibody targeting ErbB2 suppresses breast cancer growth

Seiji Kawa, Hirohisa Matsushita, Hirokazu Ohbayashi, Kentaro Semba, Tadashi Yamamoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Overexpression of ErbB2 in breast cancer is associated with increased recurrence and worse prognosis. Accumulating evidences suggest that molecular targeted therapy is a promising anticancer strategy. In this study, we produced a novel anti-ErbB2 monoclonal antibody, 6G10, that recognized an epitope distinct from the trastuzumab binding site. 6G10 induced aggregation of BT474 breast cancer cells and inhibited proliferation of various breast cancer cell lines including BT474. A growth inhibition assay showed that 6G10 had EC50 values comparable to trastuzumab, indicating that the drugs have a similar level of potency. Furthermore, intraperitoneal administration of 6G10 completely inhibited the growth of xenografted tumors derived from BT474 and SK-BR-3 cells. These data suggested that 6G10 has great therapeutic potential and could be administered to patients alternatively, or synergistically, with trastuzumab.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number3
DOIs
Publication statusPublished - 2009 Jul 3

Keywords

  • 6G10
  • Breast cancer
  • ErbB2
  • Molecular therapeutics
  • Preclinical study
  • Trastuzumab

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A novel mouse monoclonal antibody targeting ErbB2 suppresses breast cancer growth'. Together they form a unique fingerprint.

  • Cite this