A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55

Jun Ya Ueda, Takushi Togashi, Susumu Matukura, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Yasutomo Kisu, Naoki Goshima, Nobuo Nomura, Motoki Takagi, Kazuo Shin-ya

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A1 and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number7
DOIs
Publication statusPublished - 2007 Jul
Externally publishedYes

Keywords

  • JBIR-02
  • Leptomycin
  • Nuclear transport
  • Piericidin
  • Streptomyces sp.

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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