A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

Masafumi Noguchi, Eisuke Aoki, Daiki Yoshida, Etsuko Kobayashi, Shigeru Omori, Yoshihiro Muragaki, Hiroshi Iseki, Katsushige Nakamura, Ichiro Sakuma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages543-550
Number of pages8
Volume4190 LNCS - I
Publication statusPublished - 2006
Externally publishedYes
Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen
Duration: 2006 Oct 12006 Oct 6

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4190 LNCS - I
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
CityCopenhagen
Period06/10/106/10/6

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

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  • Cite this

    Noguchi, M., Aoki, E., Yoshida, D., Kobayashi, E., Omori, S., Muragaki, Y., Iseki, H., Nakamura, K., & Sakuma, I. (2006). A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4190 LNCS - I, pp. 543-550). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4190 LNCS - I).