A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

Masafumi Noguchi; Eisuke Aoki; Daiki Yoshida; Etsuko Kobayashi; Shigeru Omori; Yoshihiro Muragaki; Hiroshi Iseki; Katsushige Nakamura; Ichiro Sakuma

doi:10.1007/11866565_67

A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

Masafumi Noguchi^*, Eisuke Aoki, Daiki Yoshida, Etsuko Kobayashi, Shigeru Omori, Yoshihiro Muragaki, Hiroshi Iseki, Katsushige Nakamura, Ichiro Sakuma

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

13 Citations (Scopus)

Abstract

We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings
Publisher	Springer Verlag
Pages	543-550
Number of pages	8
ISBN (Print)	3540447075, 9783540447078
DOIs	https://doi.org/10.1007/11866565_67
Publication status	Published - 2006
Externally published	Yes
Event	9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen, Denmark Duration: 2006 Oct 1 → 2006 Oct 6

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	4190 LNCS - I
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
Country/Territory	Denmark
City	Copenhagen
Period	06/10/1 → 06/10/6

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/11866565_67

Cite this

Noguchi, M., Aoki, E., Yoshida, D., Kobayashi, E., Omori, S., Muragaki, Y., Iseki, H., Nakamura, K., & Sakuma, I. (2006). A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings (pp. 543-550). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4190 LNCS - I). Springer Verlag. https://doi.org/10.1007/11866565_67

A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. / Noguchi, Masafumi; Aoki, Eisuke; Yoshida, Daiki et al.

Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings. Springer Verlag, 2006. p. 543-550 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4190 LNCS - I).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Noguchi, M, Aoki, E, Yoshida, D, Kobayashi, E, Omori, S, Muragaki, Y, Iseki, H, Nakamura, K & Sakuma, I 2006, A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. in Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 4190 LNCS - I, Springer Verlag, pp. 543-550, 9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006, Copenhagen, Denmark, 06/10/1. https://doi.org/10.1007/11866565_67

Noguchi M, Aoki E, Yoshida D, Kobayashi E, Omori S, Muragaki Y et al. A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings. Springer Verlag. 2006. p. 543-550. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/11866565_67

Noguchi, Masafumi ; Aoki, Eisuke ; Yoshida, Daiki et al. / A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings. Springer Verlag, 2006. pp. 543-550 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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abstract = "We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.",

author = "Masafumi Noguchi and Eisuke Aoki and Daiki Yoshida and Etsuko Kobayashi and Shigeru Omori and Yoshihiro Muragaki and Hiroshi Iseki and Katsushige Nakamura and Ichiro Sakuma",

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series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

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AU - Noguchi, Masafumi

AU - Aoki, Eisuke

AU - Yoshida, Daiki

AU - Kobayashi, Etsuko

AU - Omori, Shigeru

AU - Muragaki, Yoshihiro

AU - Iseki, Hiroshi

AU - Nakamura, Katsushige

AU - Sakuma, Ichiro

PY - 2006

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AB - We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

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A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

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