A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection.

Masafumi Noguchi, Eisuke Aoki, Daiki Yoshida, Etsuko Kobayashi, Shigeru Omori, Yoshihiro Muragaki, Hiroshi Iseki, Katsushige Nakamura, Ichiro Sakuma

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 microm close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

Original languageEnglish
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages543-550
Number of pages8
Volume9
EditionPt 1
Publication statusPublished - 2006
Externally publishedYes

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Neurosurgery
Robotics
Laser Therapy
Fluorescence
Lasers
Neoplasms
Brain
Water

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Noguchi, M., Aoki, E., Yoshida, D., Kobayashi, E., Omori, S., Muragaki, Y., ... Sakuma, I. (2006). A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 1 ed., Vol. 9, pp. 543-550)

A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. / Noguchi, Masafumi; Aoki, Eisuke; Yoshida, Daiki; Kobayashi, Etsuko; Omori, Shigeru; Muragaki, Yoshihiro; Iseki, Hiroshi; Nakamura, Katsushige; Sakuma, Ichiro.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 9 Pt 1. ed. 2006. p. 543-550.

Research output: Chapter in Book/Report/Conference proceedingChapter

Noguchi, M, Aoki, E, Yoshida, D, Kobayashi, E, Omori, S, Muragaki, Y, Iseki, H, Nakamura, K & Sakuma, I 2006, A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 edn, vol. 9, pp. 543-550.
Noguchi M, Aoki E, Yoshida D, Kobayashi E, Omori S, Muragaki Y et al. A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 ed. Vol. 9. 2006. p. 543-550
Noguchi, Masafumi ; Aoki, Eisuke ; Yoshida, Daiki ; Kobayashi, Etsuko ; Omori, Shigeru ; Muragaki, Yoshihiro ; Iseki, Hiroshi ; Nakamura, Katsushige ; Sakuma, Ichiro. / A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 9 Pt 1. ed. 2006. pp. 543-550
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