A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

Masafumi Noguchi, Eisuke Aoki, Daiki Yoshida, Etsuko Kobayashi, Shigeru Omori, Yoshihiro Muragaki, Hiroshi Iseki, Katsushige Nakamura, Ichiro Sakuma

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    13 Citations (Scopus)

    Abstract

    We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

    Original languageEnglish
    Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings
    PublisherSpringer Verlag
    Pages543-550
    Number of pages8
    ISBN (Print)3540447075, 9783540447078
    DOIs
    Publication statusPublished - 2006
    Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen, Denmark
    Duration: 2006 Oct 12006 Oct 6

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume4190 LNCS - I
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Conference

    Conference9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
    CountryDenmark
    CityCopenhagen
    Period06/10/106/10/6

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

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