A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

Jae Hoon Choi, Miyuki Yoshida, Tomohiro Suzuki, Etsuko Harada, Mitsuo Kawade, Kazunaga Yazawa, Sogo Nishimoto, Hirofumi Hirai, Hirokazu Kawagishi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.

Original languageEnglish
Pages (from-to)8609-8611
Number of pages3
JournalTetrahedron
Volume69
Issue number40
DOIs
Publication statusPublished - 2013 Oct 7
Externally publishedYes

Keywords

  • Grifola gargal
  • Mushroom
  • Osteoclast-forming suppressing
  • Sphingosine
  • Structure determination
  • Structure-activity relationship

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Choi, J. H., Yoshida, M., Suzuki, T., Harada, E., Kawade, M., Yazawa, K., Nishimoto, S., Hirai, H., & Kawagishi, H. (2013). A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal. Tetrahedron, 69(40), 8609-8611. https://doi.org/10.1016/j.tet.2013.07.068