A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

Jae Hoon Choi, Miyuki Yoshida, Tomohiro Suzuki, Etsuko Harada, Mitsuo Kawade, Kazunaga Yazawa, Sogo Nishimoto, Hirofumi Hirai, Hirokazu Kawagishi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.

Original languageEnglish
Pages (from-to)8609-8611
Number of pages3
JournalTetrahedron
Volume69
Issue number40
DOIs
Publication statusPublished - 2013 Oct 7
Externally publishedYes

Fingerprint

Grifola
Sphingosine
Agaricales
Osteoclasts
Toxicity

Keywords

  • Grifola gargal
  • Mushroom
  • Osteoclast-forming suppressing
  • Sphingosine
  • Structure determination
  • Structure-activity relationship

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Choi, J. H., Yoshida, M., Suzuki, T., Harada, E., Kawade, M., Yazawa, K., ... Kawagishi, H. (2013). A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal. Tetrahedron, 69(40), 8609-8611. https://doi.org/10.1016/j.tet.2013.07.068

A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal. / Choi, Jae Hoon; Yoshida, Miyuki; Suzuki, Tomohiro; Harada, Etsuko; Kawade, Mitsuo; Yazawa, Kazunaga; Nishimoto, Sogo; Hirai, Hirofumi; Kawagishi, Hirokazu.

In: Tetrahedron, Vol. 69, No. 40, 07.10.2013, p. 8609-8611.

Research output: Contribution to journalArticle

Choi, JH, Yoshida, M, Suzuki, T, Harada, E, Kawade, M, Yazawa, K, Nishimoto, S, Hirai, H & Kawagishi, H 2013, 'A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal', Tetrahedron, vol. 69, no. 40, pp. 8609-8611. https://doi.org/10.1016/j.tet.2013.07.068
Choi, Jae Hoon ; Yoshida, Miyuki ; Suzuki, Tomohiro ; Harada, Etsuko ; Kawade, Mitsuo ; Yazawa, Kazunaga ; Nishimoto, Sogo ; Hirai, Hirofumi ; Kawagishi, Hirokazu. / A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal. In: Tetrahedron. 2013 ; Vol. 69, No. 40. pp. 8609-8611.
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