A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

Jae Hoon Choi; Miyuki Yoshida; Tomohiro Suzuki; Etsuko Harada; Mitsuo Kawade; Kazunaga Yazawa; Sogo Nishimoto; Hirofumi Hirai; Hirokazu Kawagishi

doi:10.1016/j.tet.2013.07.068

A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

Jae Hoon Choi, Miyuki Yoshida, Tomohiro Suzuki, Etsuko Harada, Mitsuo Kawade, Kazunaga Yazawa, Sogo Nishimoto, Hirofumi Hirai, Hirokazu Kawagishi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.

Original language	English
Pages (from-to)	8609-8611
Number of pages	3
Journal	Tetrahedron
Volume	69
Issue number	40
DOIs	https://doi.org/10.1016/j.tet.2013.07.068
Publication status	Published - 2013 Oct 7
Externally published	Yes

Keywords

Grifola gargal
Mushroom
Osteoclast-forming suppressing
Sphingosine
Structure determination
Structure-activity relationship

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tet.2013.07.068

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title = "A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal",

abstract = "A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.",

keywords = "Grifola gargal, Mushroom, Osteoclast-forming suppressing, Sphingosine, Structure determination, Structure-activity relationship",

author = "Choi, {Jae Hoon} and Miyuki Yoshida and Tomohiro Suzuki and Etsuko Harada and Mitsuo Kawade and Kazunaga Yazawa and Sogo Nishimoto and Hirofumi Hirai and Hirokazu Kawagishi",

year = "2013",

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day = "7",

doi = "10.1016/j.tet.2013.07.068",

language = "English",

volume = "69",

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T1 - A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

AU - Choi, Jae Hoon

AU - Yoshida, Miyuki

AU - Suzuki, Tomohiro

AU - Harada, Etsuko

AU - Kawade, Mitsuo

AU - Yazawa, Kazunaga

AU - Nishimoto, Sogo

AU - Hirai, Hirofumi

AU - Kawagishi, Hirokazu

PY - 2013/10/7

Y1 - 2013/10/7

N2 - A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.

AB - A novel sphingosine, 1,2-diacetylsphingosine (1), was isolated from the edible mushroom Grifola gargal. The structure of 1 was determined by the interpretation of spectroscopic data. Compound 1 suppressed the formation of osteoclast without toxicity.

KW - Grifola gargal

KW - Mushroom

KW - Osteoclast-forming suppressing

KW - Sphingosine

KW - Structure determination

KW - Structure-activity relationship

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UR - http://www.scopus.com/inward/citedby.url?scp=84882926677&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2013.07.068

DO - 10.1016/j.tet.2013.07.068

M3 - Article

AN - SCOPUS:84882926677

SN - 0040-4020

VL - 69

SP - 8609

EP - 8611

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -

A novel sphingosine with osteoclast-forming suppressing activity, from the edible mushroom Grifola gargal

Abstract

Keywords

ASJC Scopus subject areas

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