A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression

Wen Li Hsu, Mami Noda, Tohru Yoshioka, Etsuro Ito*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer is an aging-associated disease and caused by genomic instability that is driven by the accumulation of mutations and epimutations in the aging process. Although Ca2+ signaling, reactive oxygen species (ROS) accumulation, DNA damage response (DDR) and senescence inflammation response (SIR) are processed during genomic instability, the underlying mechanism for the cause of genomic instability and cancer development is still poorly understood and needs to be investigated. Nociceptive transient receptor potential (TRP) channels, which firstly respond to environmental stimuli, such as microbes, chemicals or physical injuries, potentiate regulation of the aging process by Ca2+ signaling. In this review, the authors provide an explanation of the dual role of nociceptive TRP channels in regulating cancer progression, initiating cancer progression by aging-induced genomic instability, and promoting malignancy by epigenetic regulation. Thus, therapeutically targeting nociceptive TRP channels seems to be a novel strategy for treating cancers.

Original languageEnglish
Pages (from-to)401-415
Number of pages15
JournalExploration of Targeted Anti-tumor Therapy
Volume2
Issue number5
DOIs
Publication statusPublished - 2021

Keywords

  • Aging
  • cancer progression
  • nociceptive transient receptor potential channel

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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